{"id":"https://openalex.org/W2000315199","doi":"https://doi.org/10.1074/jbc.m205261200","title":"Measuring Kinesin's First Step","display_name":"Measuring Kinesin's First Step","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2000315199","doi":"https://doi.org/10.1074/jbc.m205261200","mag":"2000315199","pmid":"https://pubmed.ncbi.nlm.nih.gov/12122000"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m205261200","doi":"https://doi.org/10.1074/jbc.m205261200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m205261200","pdf_url":"http://www.jbc.org/article/S0021925818366535/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818366535/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020641571","display_name":"Steven S. Rosenfeld","orcid":"https://orcid.org/0000-0003-1909-7116","observed_orcids":["https://orcid.org/0000-0003-1909-7116"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven S. Rosenfeld","raw_affiliation_strings":["Department of Neurology, University of Alabama at Birmingham and Neurology Service, Department of Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA. stevensr@uab.edu","Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Alabama at Birmingham and Neurology Service, Department of Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA. stevensr@uab.edu","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111182452","display_name":"Jun Wu Xing","orcid":"https://orcid.org/0009-0005-5215-4575","observed_orcids":["https://orcid.org/0009-0005-5215-4575"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Xing","raw_affiliation_strings":["Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060459957","display_name":"Geraldine M. Jefferson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geraldine M. Jefferson","raw_affiliation_strings":["Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456091","display_name":"Herbert C. Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert C. Cheung","raw_affiliation_strings":["Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085472899","display_name":"Peter H. King","orcid":"https://orcid.org/0000-0001-9391-7464","observed_orcids":["https://orcid.org/0000-0001-9391-7464"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. King","raw_affiliation_strings":["Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294","Neurology Service, Department of Veterans Affairs Medical Center, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Neurology Service, Department of Veterans Affairs Medical Center, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I4210115616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020641571"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.478,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.78342209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"277","issue":"39","first_page":"36731","last_page":"36739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin","display_name":"kinesin","score":1.0},{"id":"https://openalex.org/keywords/microtubule-binding","display_name":"microtubule binding","score":0.8560000061988831},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/step-kinetics","display_name":"step kinetics","score":0.41999998688697815},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.671999990940094},{"id":"https://openalex.org/keywords/microtubule-motors","display_name":"microtubule motor proteins","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.8631507158279419},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37091851234436035},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3667886257171631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33708077669143677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32752421498298645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26067790389060974},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.23209914565086365}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004735","descriptor_name":"Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m205261200","doi":"https://doi.org/10.1074/jbc.m205261200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m205261200","pdf_url":"http://www.jbc.org/article/S0021925818366535/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12122000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12122000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m205261200","doi":"https://doi.org/10.1074/jbc.m205261200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m205261200","pdf_url":"http://www.jbc.org/article/S0021925818366535/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000315199.pdf","grobid_xml":"https://content.openalex.org/works/W2000315199.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1487659884","https://openalex.org/W1523096427","https://openalex.org/W1589896765","https://openalex.org/W1593716142","https://openalex.org/W1963716975","https://openalex.org/W1965288981","https://openalex.org/W1965883439","https://openalex.org/W1967565101","https://openalex.org/W1967609633","https://openalex.org/W1968670936","https://openalex.org/W1971655236","https://openalex.org/W1976612957","https://openalex.org/W1978243335","https://openalex.org/W1984108094","https://openalex.org/W1987314485","https://openalex.org/W1998589171","https://openalex.org/W1998705722","https://openalex.org/W2014030740","https://openalex.org/W2024125528","https://openalex.org/W2026566036","https://openalex.org/W2028625344","https://openalex.org/W2043341507","https://openalex.org/W2043447781","https://openalex.org/W2044597760","https://openalex.org/W2052283532","https://openalex.org/W2052647531","https://openalex.org/W2055870007","https://openalex.org/W2057915370","https://openalex.org/W2062419779","https://openalex.org/W2065168710","https://openalex.org/W2066758359","https://openalex.org/W2075640953","https://openalex.org/W2082002895","https://openalex.org/W2093593955","https://openalex.org/W2102145519","https://openalex.org/W2119482058","https://openalex.org/W2151130369","https://openalex.org/W2155391189","https://openalex.org/W2167179372","https://openalex.org/W2170893640","https://openalex.org/W2171342763","https://openalex.org/W2171884409"],"related_works":["https://openalex.org/W1618955965","https://openalex.org/W1619209825","https://openalex.org/W2075640953","https://openalex.org/W7098127298","https://openalex.org/W2994850328","https://openalex.org/W3204543298","https://openalex.org/W2291768908","https://openalex.org/W1966790730","https://openalex.org/W1984108094","https://openalex.org/W1984376417"],"abstract_inverted_index":{"A":[0],"variety":[1],"of":[2,61,98,114,125,149],"models":[3,26,124],"have":[4,81,107,129],"recently":[5],"emerged":[6],"to":[7,16,77,120,141,155],"explain":[8],"how":[9,158,172],"the":[10,44,50,86,96,105,112,166],"molecular":[11],"motor":[12,45,99],"kinesin":[13,126,160],"is":[14,63,118,139,175],"able":[15],"maintain":[17],"processive":[18,173],"movement":[19,174],"for":[20],"over":[21],"100":[22],"steps.":[23],"Although":[24],"these":[25,150],"differ":[27],"in":[28,56,75],"significant":[29],"features,":[30],"they":[31],"all":[32],"predict":[33],"that":[34],"kinesin's":[35],"catalytic":[36],"domains":[37],"intermittently":[38],"separate":[39],"from":[40,104,165],"each":[41],"other":[42],"as":[43,93,95],"takes":[46],"8-nm":[47],"steps":[48,161],"along":[49],"microtubule.":[51],"Furthermore,":[52,85],"at":[53,88],"some":[54],"point":[55],"this":[57,78,90,115,131,178],"process,":[58],"one":[59],"molecule":[60],"ATP":[62],"hydrolyzed":[64],"per":[65],"step.":[66],"However,":[67],"exactly":[68],"when":[69],"hydrolysis":[70],"and":[71,102,163,168],"product":[72],"release":[73,103],"occur":[74],"relation":[76],"forward":[79],"step":[80],"not":[82,108],"been":[83,109],"established.":[84],"rate":[87],"which":[89],"separation":[91,143],"occurs":[92],"well":[94],"speed":[97],"stepping":[100],"onto":[101,162],"microtubule":[106,145,167],"measured.":[110],"In":[111],"absence":[113],"information,":[116],"it":[117],"difficult":[119],"critically":[121],"evaluate":[122],"competing":[123],"function.":[127],"We":[128],"addressed":[130],"issue":[132],"by":[133,177],"developing":[134],"spectroscopic":[135],"probes":[136],"whose":[137],"fluorescence":[138,151],"sensitive":[140],"motor-motor":[142],"or":[144],"binding.":[146],"The":[147],"kinetics":[148],"changes":[152],"allow":[153],"us":[154],"directly":[156],"measure":[157],"fast":[159],"releases":[164],"provide":[169],"insight":[170],"into":[171],"maintained":[176],"motor.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
