{"id":"https://openalex.org/W2000309597","doi":"https://doi.org/10.1111/jnc.13019","title":"Side\u2010chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation","display_name":"Side\u2010chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation","publication_year":2014,"publication_date":"2014-12-31","ids":{"openalex":"https://openalex.org/W2000309597","doi":"https://doi.org/10.1111/jnc.13019","mag":"2000309597","pmid":"https://pubmed.ncbi.nlm.nih.gov/25620628"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.13019","doi":"https://doi.org/10.1111/jnc.13019","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.13019","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005381448","display_name":"Vasileios C. Mastorodemos","orcid":"https://orcid.org/0000-0002-7397-2930","observed_orcids":["https://orcid.org/0000-0002-7397-2930"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios Mastorodemos","raw_affiliation_strings":["Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004503378","display_name":"Konstantinos Kanavouras","orcid":"https://orcid.org/0000-0003-4655-9523","observed_orcids":["https://orcid.org/0000-0003-4655-9523"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Kanavouras","raw_affiliation_strings":["Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007001865","display_name":"Shobana Sundaram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobana Sundaram","raw_affiliation_strings":["Department of Physiology and Biophysics; Virginia Commonwealth University; School of Medicine; Richmond Virginia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics; Virginia Commonwealth University; School of Medicine; Richmond Virginia USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048741230","display_name":"Mary Providaki","orcid":"https://orcid.org/0000-0003-0904-1362","observed_orcids":["https://orcid.org/0000-0003-0904-1362"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Providaki","raw_affiliation_strings":["Department of Biology, University of Crete, Heraklion /Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Crete, Heraklion /Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020637214","display_name":"Zoe Petraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Zoe Petraki","raw_affiliation_strings":["Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031019280","display_name":"Michael Kokkinidis","orcid":"https://orcid.org/0000-0002-3112-6904","observed_orcids":["https://orcid.org/0000-0002-3112-6904"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michael Kokkinidis","raw_affiliation_strings":["Department of Biology, University of Crete, Heraklion /Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Crete, Heraklion /Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040448710","display_name":"Ioannis V. Zaganas","orcid":"https://orcid.org/0000-0002-0774-5772","observed_orcids":["https://orcid.org/0000-0002-0774-5772"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Zaganas","raw_affiliation_strings":["Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021819560","display_name":"Diomedes E. Logothetis","orcid":"https://orcid.org/0000-0002-0576-884X","observed_orcids":["https://orcid.org/0000-0002-0576-884X","https://orcid.org/0000-0002-0384-073X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diomedes E. Logothetis","raw_affiliation_strings":["Department of Physiology and Biophysics; Virginia Commonwealth University; School of Medicine; Richmond Virginia USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics; Virginia Commonwealth University; School of Medicine; Richmond Virginia USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030449929","display_name":"Andreas Plaitakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Andreas Plaitakis","raw_affiliation_strings":["Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Neurology, School of Health Sciences, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030449929"],"corresponding_institution_ids":["https://openalex.org/I142617266"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.5664,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56901688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"133","issue":"1","first_page":"73","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/side-chain-interactions","display_name":"side-chain interactions","score":0.7540000081062317},{"id":"https://openalex.org/keywords/regulatory-domain","display_name":"regulatory domain","score":0.753000020980835},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gtp-inhibition","display_name":"GTP inhibition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/adp-activation","display_name":"ADP stimulation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/thermal-inactivation","display_name":"thermal inactivation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.3400000035762787},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5258629322052002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5073983073234558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4977722465991974},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.481403112411499},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45952898263931274},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.4587869942188263},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.45736369490623474},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4112773537635803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3403659164905548},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3070172667503357},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2817271947860718},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1722494661808014},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1091625988483429}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jnc.13019","doi":"https://doi.org/10.1111/jnc.13019","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.13019","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:25620628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25620628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W3595601","https://openalex.org/W1971050989","https://openalex.org/W1973175579","https://openalex.org/W1995240857","https://openalex.org/W1996503280","https://openalex.org/W2008398516","https://openalex.org/W2023256284","https://openalex.org/W2029453559","https://openalex.org/W2054017160","https://openalex.org/W2059994550","https://openalex.org/W2060723204","https://openalex.org/W2073614544","https://openalex.org/W2084578352","https://openalex.org/W2095021929","https://openalex.org/W2096962761","https://openalex.org/W2107317356","https://openalex.org/W2123715446","https://openalex.org/W2132262459","https://openalex.org/W2152622208","https://openalex.org/W2168394910","https://openalex.org/W2183844006","https://openalex.org/W4231627353"],"related_works":["https://openalex.org/W2152622208","https://openalex.org/W2078821377","https://openalex.org/W1971719161","https://openalex.org/W1972012489","https://openalex.org/W1968086812","https://openalex.org/W2002168701","https://openalex.org/W1995240857","https://openalex.org/W1985083001","https://openalex.org/W2158899331","https://openalex.org/W1995287413"],"abstract_inverted_index":{"Abstract":[0],"Glutamate":[1,248],"Dehydrogenase":[2],"(GDH)":[3,250],"is":[4,22,44,90,251,280],"central":[5,17,252],"to":[6,39,70,92,171,244,253,278,296,347],"the":[7,47,74,107,121,139,159,174,193,210,216,228,254,257,331],"metabolism":[8,255,266],"of":[9,64,77,84,98,117,151,165,192,215,231,256,300,313,334],"glutamate,":[10,260],"a":[11,288],"major":[12],"excitatory":[13,258],"transmitter":[14,259],"in":[15,46,88,120,132,155,158,187,204,208,227,267,276,306,330],"mammalian":[16],"nervous":[18],"system":[19],"(CNS).":[20],"hGDH1":[21,89,195,217,307],"activated":[23],"by":[24,31,128,202],"ADP":[25],"and":[26,28,100,115,149,162,224,241,261,270,315,327,344],"L\u2010leucine":[27,102,317],"powerfully":[29],"inhibited":[30],"GTP.":[32],"Besides":[33],"this":[34,78],"housekeeping":[35],"hGDH1,":[36,279],"duplication":[37],"led":[38],"an":[40],"hGDH2":[41,205],"isoform":[42,274],"that":[43,147,163,322],"expressed":[45],"human":[48],"brain":[49],"dissociating":[50],"its":[51],"function":[52],"from":[53,282],"GTP":[54,283],"control.":[55],"The":[56,134,273],"novel":[57],"enzyme":[58],"has":[59,287],"reduced":[60,289],"basal":[61,94,236,290,309,339],"activity":[62,95,310],"(4\u20136%":[63],"capacity)":[65,99,314],"while":[66],"remaining":[67],"remarkably":[68],"responsive":[69,295],"ADP/L\u2010leucine":[71,297],"activation.":[72,103,298,318],"While":[73],"molecular":[75],"basis":[76],"evolutionary":[79],"adaptation":[80],"remains":[81,293],"unclear,":[82],"substitution":[83],"Ser":[85],"for":[86,235,303,338],"Arg443":[87,114,150,203],"shown":[91],"diminish":[93],"(<":[96,311],"2%":[97,312],"abrogate":[101],"To":[104],"explore":[105],"whether":[106],"Arg443Ser":[108],"mutation":[109,141,176],"disrupts":[110],"hydrogen":[111],"bonding":[112],"between":[113,222,325],"Ser409":[116,127,148],"adjacent":[118],"monomers":[119,153],"regulatory":[122,332],"domain":[123,333],"(\u2018antenna\u2019),":[124],"we":[125],"replaced":[126,201],"Arg":[129],"or":[130,167],"Asp":[131],"hGDH1.":[133],"Ser409Arg\u20101":[135],"change":[136],"essentially":[137],"replicated":[138],"Arg443Ser\u20101":[140],"effects.":[142],"Molecular":[143],"dynamics":[144],"simulation":[145],"predicted":[146],"neighboring":[152],"come":[154],"close":[156],"proximity":[157],"open":[160],"conformation":[161],"introduction":[164],"Ser443\u20101":[166],"Arg409\u20101":[168],"causes":[169],"them":[170],"separate":[172],"with":[173,264],"swap":[175],"(Arg409/Ser443)":[177],"reinstating":[178],"their":[179],"proximity.":[180],"A":[181],"swapped":[182],"Ser409Arg/Arg443Ser\u20101":[183],"mutant":[184,212],"protein,":[185],"obtained":[186],"recombinant":[188],"form,":[189],"regained":[190],"most":[191,214],"wild\u2010type":[194],"properties.":[196,218],"Also,":[197],"when":[198],"Ser443":[199],"was":[200],"(as":[206],"occurs":[207],"hGDH1),":[209],"Ser443Arg\u20102":[211],"acquired":[213],"Hence,":[219],"side\u2010chain":[220,323],"interactions":[221,324],"409":[223,326],"443":[225,328],"positions":[226,329],"\u2018antenna\u2019":[229],"region":[230],"hGDHs":[232],"are":[233,336],"crucial":[234,337],"catalytic":[237,340],"activity,":[238,291,341],"allosteric":[239,342],"regulation,":[240,343],"relative":[242,345],"resistance":[243,346],"thermal":[245,348],"inactivation.":[246,349],"image":[247],"dehydrogenase":[249],"links":[262],"it":[263],"carbohydrate":[265],"energy":[268],"homeostasis":[269],"cell":[271],"signaling.":[272],"hGDH2,":[275],"contrast":[277],"dissociated":[281],"(guanosine":[284],"triphosphate)":[285],"control,":[286],"but":[292],"highly":[294],"Substitution":[299],"Serine":[301],"(Ser)":[302],"arginine":[304],"(Arg443)":[305],"diminishes":[308],"abrogates":[316],"We":[319],"provide":[320],"evidence":[321],"GDH":[335]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
