{"id":"https://openalex.org/W2000307461","doi":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","title":"TGF\u2010\u03b21 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation","display_name":"TGF\u2010\u03b21 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation","publication_year":2010,"publication_date":"2010-03-08","ids":{"openalex":"https://openalex.org/W2000307461","doi":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","mag":"2000307461","pmid":"https://pubmed.ncbi.nlm.nih.gov/20219075"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.2010.01512.x","doi":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11158283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037575379","display_name":"Shouli Wang","orcid":"https://orcid.org/0000-0001-7958-1757","observed_orcids":["https://orcid.org/0000-0001-7958-1757"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shouli Wang","raw_affiliation_strings":["Department of Pathology, Soochow University School of Medicine, Suzhou, China. wangsoly112@hotmail.com","Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Soochow University School of Medicine, Suzhou, China. wangsoly112@hotmail.com","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013550834","display_name":"Lingchuan Guo","orcid":"https://orcid.org/0000-0002-0608-5143","observed_orcids":["https://orcid.org/0000-0002-0608-5143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingchuan Guo","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627483","display_name":"Liang Dong","orcid":"https://orcid.org/0000-0002-7145-5569","observed_orcids":["https://orcid.org/0000-0002-7145-5569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Dong","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101970767","display_name":"Lingling Guo","orcid":"https://orcid.org/0000-0003-4117-9062","observed_orcids":["https://orcid.org/0000-0003-4117-9062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingling Guo","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigang Li","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417643","display_name":"Jiajia Zhang","orcid":"https://orcid.org/0000-0003-0385-9278","observed_orcids":["https://orcid.org/0000-0003-0385-9278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiajia Zhang","raw_affiliation_strings":["Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112105306","display_name":"Maomin Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Maomin Sun","raw_affiliation_strings":["Anatomy, Soochow University School of Medicine, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy, Soochow University School of Medicine, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037575379","https://openalex.org/A5112105306"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":null,"fwci":0.8291,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.68936552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"5","first_page":"1108","last_page":"1116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/myosin","display_name":"myosin","score":0.7110000252723694},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.6430000066757202},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.5320000052452087},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.6589999794960022},{"id":"https://openalex.org/keywords/rd-cells","display_name":"RD cells","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.8540410995483398},{"id":"https://openalex.org/C2778106681","wikidata":"https://www.wikidata.org/wiki/Q416095","display_name":"MyoD","level":4,"score":0.7360894680023193},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.732358992099762},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.692962646484375},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.6380685567855835},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5423551201820374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5163910984992981},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4675183594226837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4521598219871521},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4406958520412445},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4250241219997406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4167366027832031},{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.4124011993408203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34578174352645874},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.33708804845809937},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29951202869415283},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2903962731361389},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.27325308322906494},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2341134250164032},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.19237545132637024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15666905045509338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14097601175308228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10969197750091553},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.10351279377937317},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.09367164969444275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012208","descriptor_name":"Rhabdomyosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1349-7006.2010.01512.x","doi":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2010.01512.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:20219075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20219075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11158283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11158283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11158283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11158283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W90817957","https://openalex.org/W118376196","https://openalex.org/W1138153862","https://openalex.org/W1565701768","https://openalex.org/W1581496967","https://openalex.org/W1596142420","https://openalex.org/W1966387132","https://openalex.org/W1975392093","https://openalex.org/W1977590314","https://openalex.org/W1985810123","https://openalex.org/W1993534485","https://openalex.org/W2003718158","https://openalex.org/W2005985562","https://openalex.org/W2010386771","https://openalex.org/W2011243140","https://openalex.org/W2025806580","https://openalex.org/W2028476252","https://openalex.org/W2035913563","https://openalex.org/W2038347351","https://openalex.org/W2038783205","https://openalex.org/W2046286320","https://openalex.org/W2055081674","https://openalex.org/W2065769290","https://openalex.org/W2073049752","https://openalex.org/W2078985610","https://openalex.org/W2094361185","https://openalex.org/W2094769354","https://openalex.org/W2103303024","https://openalex.org/W2113813396","https://openalex.org/W2116961946","https://openalex.org/W2119734298","https://openalex.org/W2124879766","https://openalex.org/W2135859152","https://openalex.org/W2139932210","https://openalex.org/W2140771257","https://openalex.org/W2141884708","https://openalex.org/W2155544045","https://openalex.org/W2164733896","https://openalex.org/W2167041446","https://openalex.org/W2177035195","https://openalex.org/W2408799336"],"related_works":["https://openalex.org/W1884838825","https://openalex.org/W2157491055","https://openalex.org/W4229490071","https://openalex.org/W2065829112","https://openalex.org/W1999820213","https://openalex.org/W2167315148","https://openalex.org/W3171772225","https://openalex.org/W2005268809","https://openalex.org/W2046296502","https://openalex.org/W4367599012"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,25,42,89,107,130,137,189,211],"transforming":[2],"growth":[3,88],"factor-beta1":[4],"(TGF-beta1)":[5],"and":[6,44,53,65,74,99,124,140,154,166,194],"its":[7,45],"downstream":[8,46],"molecules":[9,47],"in":[10,58,61,144,149,168,191],"the":[11,22,35,87,118,131,152,186,197],"rhabdomyosarcoma":[12,109],"(RMS)":[13],"RD":[14,90],"cell":[15],"line":[16],"has":[17,29],"been":[18,31],"reported":[19],"previously,":[20],"but":[21],"regulatory":[23],"role":[24],"TGF-beta1":[26,43,72,80,174,190,198],"on":[27],"RMS":[28,59,170],"not":[30],"studied":[32],"extensively.":[33],"In":[34],"present":[36],"study,":[37],"we":[38],"showed":[39,172],"that":[40,173,196,208],"expression":[41,73],"type":[48],"II":[49],"TGF-beta":[50],"receptor":[51],"(TbetaRII)":[52],"Smad4":[54],"was":[55,67,93,141],"significantly":[56,85],"higher":[57,143],"than":[60,147],"normal":[62,119],"skeletal":[63],"muscle,":[64],"there":[66],"a":[68,105,114,202],"significant":[69],"relationship":[70],"between":[71],"histological":[75],"grade.":[76],"Gene":[77],"silencing":[78],"with":[79,159],"short-hairpin":[81],"RNA":[82],"(shRNA)-expressing":[83],"vectors":[84],"decreased":[86],"cells,":[91],"which":[92],"confirmed":[94],"by":[95],"caspase-3":[96],"(in":[97,101],"vitro)":[98],"TUNEL":[100],"vivo)":[102],"assays.":[103],"Moreover,":[104],"proportion":[106],"treated":[108],"(RD)":[110],"cells":[111],"changed":[112],"to":[113],"round":[115],"shape":[116,123],"from":[117],"fusiform":[120],"or":[121],"polygonal":[122],"expressed":[125],"myofilaments.":[126],"Myogenin":[127],"is":[128,201],"one":[129],"myogenic":[132,138,160],"differentiation":[133,161,210],"genes":[134],"(MyoD)":[135],"family":[136],"regulators,":[139],"obviously":[142],"TGF-beta1-shRNA-treated":[145],"tumors":[146],"it":[148],"control":[150],"at":[151],"mRNA":[153],"protein":[155],"level.":[156],"Immunohistochemical":[157],"staining":[158,177],"markers":[162],"such":[163],"as":[164],"myosin":[165],"desmin":[167],"subcutaneous":[169],"tissue":[171],"shRNA":[175],"increased":[176],"for":[178,206],"myosin.":[179],"These":[180],"results":[181],"provide":[182],"new":[183],"insight":[184],"into":[185],"biological":[187],"function":[188],"malignant":[192],"tumors,":[193],"imply":[195],"signal":[199],"pathway":[200],"potential":[203],"therapeutic":[204],"target":[205],"drugs":[207],"induce":[209],"RMS.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
