{"id":"https://openalex.org/W2000306533","doi":"https://doi.org/10.4161/cc.9.13.12060","title":"HtrA2, taming the oncogenic activities of WT1","display_name":"HtrA2, taming the oncogenic activities of WT1","publication_year":2010,"publication_date":"2010-06-15","ids":{"openalex":"https://openalex.org/W2000306533","doi":"https://doi.org/10.4161/cc.9.13.12060","mag":"2000306533","pmid":"https://pubmed.ncbi.nlm.nih.gov/20543571","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3040848"},"language":"en","primary_location":{"id":"doi:10.4161/cc.9.13.12060","doi":"https://doi.org/10.4161/cc.9.13.12060","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.13.12060","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.13.12060?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.13.12060?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084106145","display_name":"J\u00f6rg Hartkamp","orcid":"https://orcid.org/0000-0002-6863-9228","observed_orcids":["https://orcid.org/0000-0002-6863-9228"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Hartkamp","raw_affiliation_strings":["Faculty of Life Sciences, The Michael Smith Building, University of Manchester, Manchester, UK","Faculty of Life Sciences","Manchester, UK","University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The Michael Smith Building, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Faculty of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Manchester, UK","institution_ids":[]},{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025733630","display_name":"Stefan G. E. Roberts","orcid":"https://orcid.org/0000-0002-7535-6365","observed_orcids":["https://orcid.org/0000-0002-7535-6365"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefan G.E. Roberts","raw_affiliation_strings":["Department of Biological Sciences; University at Buffalo; Buffalo, New York USA","Buffalo, New York USA","Department of Biological Sciences","University at Buffalo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences; University at Buffalo; Buffalo, New York USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Buffalo, New York USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"University at Buffalo","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025733630"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":null,"apc_paid":null,"fwci":0.8119,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73431154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"13","first_page":"2508","last_page":"2514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htra2","display_name":"HtrA2","score":0.949999988079071},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/wilms-tumor-1","display_name":"Wilms tumor 1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.7269999980926514},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7839999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumour-suppressor","display_name":"tumour suppressor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8494191765785217},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7335497140884399},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7124156951904297},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5564090013504028},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.551008939743042},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49405696988105774},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.49198195338249207},{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.4880920648574829},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47285914421081543},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4494171738624573},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4263290762901306},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4104878604412079},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30015668272972107},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25566279888153076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18820708990097046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16443467140197754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074923","descriptor_name":"High-Temperature Requirement A Serine Peptidase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025721","descriptor_name":"WT1 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025721","descriptor_name":"WT1 Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.9.13.12060","doi":"https://doi.org/10.4161/cc.9.13.12060","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.13.12060","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.13.12060?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:20543571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20543571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3040848","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3040848/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cc.9.13.12060","doi":"https://doi.org/10.4161/cc.9.13.12060","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.13.12060","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.13.12060?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000306533.pdf","grobid_xml":"https://content.openalex.org/works/W2000306533.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1562515516","https://openalex.org/W1906142356","https://openalex.org/W1966340685","https://openalex.org/W1966672621","https://openalex.org/W1976160299","https://openalex.org/W1976615153","https://openalex.org/W1977004221","https://openalex.org/W1978700214","https://openalex.org/W1983228128","https://openalex.org/W1984485808","https://openalex.org/W1994929145","https://openalex.org/W1997203379","https://openalex.org/W1998762172","https://openalex.org/W2002559335","https://openalex.org/W2003442577","https://openalex.org/W2004723089","https://openalex.org/W2005391709","https://openalex.org/W2007037481","https://openalex.org/W2007889578","https://openalex.org/W2008305226","https://openalex.org/W2009885873","https://openalex.org/W2021817265","https://openalex.org/W2021933660","https://openalex.org/W2022404774","https://openalex.org/W2031468720","https://openalex.org/W2034165978","https://openalex.org/W2036635542","https://openalex.org/W2046069452","https://openalex.org/W2047449144","https://openalex.org/W2048932138","https://openalex.org/W2052185565","https://openalex.org/W2053772791","https://openalex.org/W2056514645","https://openalex.org/W2060470131","https://openalex.org/W2063197555","https://openalex.org/W2064722919","https://openalex.org/W2065964187","https://openalex.org/W2072631602","https://openalex.org/W2081469183","https://openalex.org/W2085692902","https://openalex.org/W2086554981","https://openalex.org/W2087290491","https://openalex.org/W2087956326","https://openalex.org/W2089253181","https://openalex.org/W2090606069","https://openalex.org/W2090954031","https://openalex.org/W2091305335","https://openalex.org/W2094946788","https://openalex.org/W2095579742","https://openalex.org/W2096381270","https://openalex.org/W2098111179","https://openalex.org/W2102443458","https://openalex.org/W2104966162","https://openalex.org/W2105878939","https://openalex.org/W2106870473","https://openalex.org/W2110075925","https://openalex.org/W2110483280","https://openalex.org/W2113471832","https://openalex.org/W2115566569","https://openalex.org/W2115687796","https://openalex.org/W2116654405","https://openalex.org/W2124373444","https://openalex.org/W2129367933","https://openalex.org/W2134468897","https://openalex.org/W2140555803","https://openalex.org/W2141732393","https://openalex.org/W2149052195","https://openalex.org/W2150169944","https://openalex.org/W2152165298","https://openalex.org/W2153689486","https://openalex.org/W2161264672","https://openalex.org/W2162177534","https://openalex.org/W2165648275","https://openalex.org/W2322288555","https://openalex.org/W4323873844"],"related_works":["https://openalex.org/W1992950815","https://openalex.org/W2115566569","https://openalex.org/W2021933660","https://openalex.org/W1997203379","https://openalex.org/W2324980317","https://openalex.org/W2037324207","https://openalex.org/W2901216688","https://openalex.org/W2596296630","https://openalex.org/W2140555803","https://openalex.org/W2051069729"],"abstract_inverted_index":{"Wilms'":[0,20,50],"tumour":[1,21,62,116,199],"is":[2,10,25,43,104,178,195],"a":[3,26,61,107,136,198],"paediatric":[4,202],"malignancy":[5],"of":[6,12,84,88,94,106,115,126,139,154,170,183],"the":[7,13,53,82,92,113,124,129,141,181],"kidneys":[8],"and":[9,40,98,144,164],"one":[11],"most":[14],"common":[15],"solid":[16],"childhood":[17],"cancers.":[18],"The":[19,86,151],"1":[22],"protein":[23,56],"(WT1)":[24],"transcription":[27],"factor":[28],"that":[29,69,112],"can":[30],"either":[31],"activate":[32],"or":[33,46],"repress":[34],"genes":[35],"involved":[36],"in":[37,49,77,166,201],"growth,":[38],"apoptosis":[39],"differentiation.":[41],"It":[42],"frequently":[44],"mutated":[45],"aberrantly":[47],"expressed":[48],"tumour,":[51],"where":[52,186],"wild":[54,70],"type":[55,71],"would":[57,207],"normally":[58],"act":[59],"as":[60,74,189,197],"suppressor.":[63],"Several":[64],"studies,":[65],"however,":[66],"have":[67],"found":[68,111],"WT1":[72,89,127,147,155,171,187,194],"acts":[73,188],"an":[75,190],"oncogene":[76],"adult":[78,96,184],"tumours,":[79],"primarily":[80],"through":[81],"inhibition":[83],"apoptosis.":[85,175],"expression":[87,101],"correlates":[90],"with":[91,119],"aggressiveness":[93],"several":[95],"cancers,":[97],"its":[99,158],"continued":[100],"following":[102],"treatment":[103,114,182],"indicative":[105],"poor":[108],"outcome.We":[109],"recently":[110],"cell":[117],"lines":[118],"cytotoxic":[120],"drugs":[121],"leads":[122,156],"to":[123,135,157,180,210],"cleavage":[125],"by":[128,172,205],"serine":[130],"protease":[131],"HtrA2.":[132],"HtrA2":[133,173,206],"binds":[134],"specific":[137],"region":[138],"WT1,":[140],"suppression":[142],"domain,":[143],"then":[145],"cleaves":[146],"at":[148],"multiple":[149],"sites.":[150],"HtrA2-mediated":[152],"proteolysis":[153,204],"removal":[159],"from":[160],"gene":[161,167],"promoter":[162],"regions":[163],"changes":[165],"expression.":[168],"Cleavage":[169],"enhances":[174],"This":[176],"event":[177],"advantageous":[179],"tumours":[185],"oncogene.":[191],"However,":[192],"when":[193],"acting":[196],"suppressor":[200],"malignancies,":[203],"be":[208],"antagonistic":[209],"therapy.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
