{"id":"https://openalex.org/W2000304015","doi":"https://doi.org/10.1016/j.bmcl.2010.11.045","title":"Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors","display_name":"Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors","publication_year":2010,"publication_date":"2010-11-12","ids":{"openalex":"https://openalex.org/W2000304015","doi":"https://doi.org/10.1016/j.bmcl.2010.11.045","mag":"2000304015","pmid":"https://pubmed.ncbi.nlm.nih.gov/21123062"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2010.11.045","doi":"https://doi.org/10.1016/j.bmcl.2010.11.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2010.11.045","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010077201","display_name":"Linda R. Weinberg","orcid":"https://orcid.org/0000-0002-1877-566X","observed_orcids":["https://orcid.org/0000-0002-1877-566X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Linda R. Weinberg","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380-4245, USA. lweinber@cephalon.com","Worldwide Discovery Research, Cephalon, Inc. 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380-4245, USA. lweinber@cephalon.com","institution_ids":[]},{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc. 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069806610","display_name":"Mark S. Albom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark S. Albom","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113679910","display_name":"Thelma S. Angeles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thelma S. Angeles","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004891562","display_name":"Jean Husten","orcid":"https://orcid.org/0000-0002-6137-831X","observed_orcids":["https://orcid.org/0000-0002-6137-831X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Husten","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037230443","display_name":"Joseph G. Lisko","orcid":"https://orcid.org/0000-0002-9891-4403","observed_orcids":["https://orcid.org/0000-0002-9891-4403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph G. Lisko","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028609933","display_name":"Robert J. McHugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. McHugh","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086672973","display_name":"Karen L. Milkiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen L. Milkiewicz","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seetha Murthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seetha Murthy","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012330888","display_name":"Gregory R. Ott","orcid":"https://orcid.org/0009-0005-4843-6713","observed_orcids":["https://orcid.org/0009-0005-4843-6713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory R. Ott","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053772599","display_name":"Jay P. Theroff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay P. Theroff","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087195564","display_name":"Rabindranath Tripathy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabindranath Tripathy","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110063259","display_name":"Ted L. Underiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ted L. Underiner","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041662818","display_name":"Craig A. Zificsak","orcid":"https://orcid.org/0000-0001-5235-0078","observed_orcids":["https://orcid.org/0000-0001-5235-0078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig A. Zificsak","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063125862","display_name":"Bruce D. Dorsey","orcid":"https://orcid.org/0000-0002-2130-9969","observed_orcids":["https://orcid.org/0000-0002-2130-9969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce D. Dorsey","raw_affiliation_strings":["Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010077201"],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.9499,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71092355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"164","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3176000118255615,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met-kinase-inhibitors","display_name":"c-Met inhibitor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/2-4-diaminopyrimidine","display_name":"2,4-diaminopyrimidine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hgf-c-met-signaling","display_name":"HGF/MET signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7590000033378601},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-interactions","display_name":"epithelial-mesenchymal interactions","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8519835472106934},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.552398681640625},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5235487818717957},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4933077394962311},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4772365093231201},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4667658507823944},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4514238238334656},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.4470389783382416},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.42338424921035767},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.42180973291397095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4009222984313965},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3689226508140564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33748942613601685},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3356765806674957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3159469962120056},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29169580340385437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09365406632423401}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2010.11.045","doi":"https://doi.org/10.1016/j.bmcl.2010.11.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2010.11.045","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:21123062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21123062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1973405024","https://openalex.org/W2009511212","https://openalex.org/W2014582878","https://openalex.org/W2042944401","https://openalex.org/W2117750856","https://openalex.org/W2119748423","https://openalex.org/W2155167580"],"related_works":["https://openalex.org/W3169837748","https://openalex.org/W2089004247","https://openalex.org/W2082989164","https://openalex.org/W2997037689","https://openalex.org/W2387426893","https://openalex.org/W2754756259","https://openalex.org/W2604959196","https://openalex.org/W2901806147","https://openalex.org/W2315908398","https://openalex.org/W3151104500"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
