{"id":"https://openalex.org/W2000299127","doi":"https://doi.org/10.1074/mcp.m800116-mcp200","title":"Proteomics Analysis Identifies Phosphorylation-dependent \u03b1-Synuclein Protein Interactions","display_name":"Proteomics Analysis Identifies Phosphorylation-dependent \u03b1-Synuclein Protein Interactions","publication_year":2008,"publication_date":"2008-07-09","ids":{"openalex":"https://openalex.org/W2000299127","doi":"https://doi.org/10.1074/mcp.m800116-mcp200","mag":"2000299127","pmid":"https://pubmed.ncbi.nlm.nih.gov/18614564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2577212"},"language":"en","primary_location":{"id":"doi:10.1074/mcp.m800116-mcp200","doi":"https://doi.org/10.1074/mcp.m800116-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m800116-mcp200","pdf_url":"http://www.mcponline.org/article/S1535947620308811/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.mcponline.org/article/S1535947620308811/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007318655","display_name":"Melinda A. McFarland","orcid":"https://orcid.org/0000-0003-4431-1022","observed_orcids":["https://orcid.org/0000-0003-4431-1022"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda A. McFarland","raw_affiliation_strings":["National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20891, USA","National Institute of Mental Health, Bethesda, Maryland 20891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20891, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"National Institute of Mental Health, Bethesda, Maryland 20891","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102363182","display_name":"Christopher E. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher E. Ellis","raw_affiliation_strings":["NHGRI, National Institutes of Health, Bethesda, Maryland 20891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHGRI, National Institutes of Health, Bethesda, Maryland 20891","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111562890","display_name":"Sanford P. Markey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanford P. Markey","raw_affiliation_strings":["National Institute of Mental Health, Bethesda, Maryland 20891"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health, Bethesda, Maryland 20891","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044887457","display_name":"Robert Luke Nussbaum","orcid":"https://orcid.org/0000-0003-3445-8880","observed_orcids":["https://orcid.org/0000-0003-3445-8880"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Nussbaum","raw_affiliation_strings":["Department of Medicine, Division of Medical Genetics, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Medical Genetics, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044887457"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.5813,"has_fulltext":true,"cited_by_count":176,"citation_normalized_percentile":{"value":0.96875308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"7","issue":"11","first_page":"2123","last_page":"2137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9760000109672546},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.734000027179718},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.703000009059906},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.847000002861023},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.39500001072883606},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.38199999928474426},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.32100000977516174},{"id":"https://openalex.org/keywords/snca-mutations","display_name":"SNCA mutations","score":0.4449999928474426},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.781000018119812},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.4560000002384186},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.42800000309944153},{"id":"https://openalex.org/keywords/neurodegeneration-markers","display_name":"neurodegeneration biomarkers","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7392224073410034},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6294040679931641},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4967365860939026},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.46895354986190796},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.46858447790145874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41710779070854187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33927327394485474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2904805839061737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2036370038986206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0682925283908844},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.06009957194328308},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/mcp.m800116-mcp200","doi":"https://doi.org/10.1074/mcp.m800116-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m800116-mcp200","pdf_url":"http://www.mcponline.org/article/S1535947620308811/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2577212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2577212","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Proteomics","raw_type":"Text"},{"id":"pmid:18614564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18614564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/mcp.m800116-mcp200","doi":"https://doi.org/10.1074/mcp.m800116-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m800116-mcp200","pdf_url":"http://www.mcponline.org/article/S1535947620308811/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7208541472","display_name":"Proteomics in neurotoxicology","funder_award_id":"Z01MH000279","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000299127.pdf","grobid_xml":"https://content.openalex.org/works/W2000299127.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W178007352","https://openalex.org/W1485468448","https://openalex.org/W1496790952","https://openalex.org/W1502551601","https://openalex.org/W1530609782","https://openalex.org/W1970673084","https://openalex.org/W1973608140","https://openalex.org/W1974150565","https://openalex.org/W1975558168","https://openalex.org/W1977403980","https://openalex.org/W1979944790","https://openalex.org/W1983632956","https://openalex.org/W1988774439","https://openalex.org/W1989111476","https://openalex.org/W2005239190","https://openalex.org/W2009103469","https://openalex.org/W2012553386","https://openalex.org/W2020676198","https://openalex.org/W2026455995","https://openalex.org/W2030158363","https://openalex.org/W2030760120","https://openalex.org/W2032601646","https://openalex.org/W2035787181","https://openalex.org/W2038249420","https://openalex.org/W2038272035","https://openalex.org/W2046784631","https://openalex.org/W2047206971","https://openalex.org/W2049612563","https://openalex.org/W2050232580","https://openalex.org/W2054391353","https://openalex.org/W2066430727","https://openalex.org/W2066547615","https://openalex.org/W2067738760","https://openalex.org/W2070372183","https://openalex.org/W2073947021","https://openalex.org/W2077196709","https://openalex.org/W2078594804","https://openalex.org/W2080857749","https://openalex.org/W2086717125","https://openalex.org/W2097067711","https://openalex.org/W2100872265","https://openalex.org/W2103900082","https://openalex.org/W2107467915","https://openalex.org/W2107658086","https://openalex.org/W2108865709","https://openalex.org/W2114883363","https://openalex.org/W2115478133","https://openalex.org/W2123878025","https://openalex.org/W2124800531","https://openalex.org/W2128672762","https://openalex.org/W2138306686","https://openalex.org/W2153441656","https://openalex.org/W2158930854","https://openalex.org/W2231988228","https://openalex.org/W3021327657","https://openalex.org/W4246230178","https://openalex.org/W4295994768","https://openalex.org/W6607342899","https://openalex.org/W6832261992"],"related_works":["https://openalex.org/W2765890900","https://openalex.org/W2625499130","https://openalex.org/W1496790952","https://openalex.org/W2498732400","https://openalex.org/W1569465709","https://openalex.org/W1996355944","https://openalex.org/W1499834429","https://openalex.org/W4407891471","https://openalex.org/W2066304458","https://openalex.org/W78130631"],"abstract_inverted_index":{"Mutations":[0],"and":[1,23,46,79,118,172,189,241,246,252,308],"copy":[2],"number":[3,312],"variation":[4],"in":[5,101,187,214,219,300,304,309,316],"the":[6,10,55,86,181,202,210,229,235,288],"SNCA":[7],"gene":[8],"encoding":[9],"neuronal":[11],"protein":[12,56,212,264,317],"alpha-synuclein":[13,39,104,186,208,259,276,296,338],"have":[14],"been":[15],"linked":[16],"to":[17,204,244],"familial":[18,188],"Parkinson":[19,102,116],"disease":[20,88,220,230],"(Thomas,":[21],"B.,":[22],"Beal,":[24],"M.":[25,161],"F.":[26],"(2007)":[27],"Parkinson's":[28,87],"disease.":[29,193],"Hum.":[30],"Mol.":[31],"Genet.":[32],"16,":[33],"R183-R194).":[34],"The":[35],"carboxyl":[36,260,277],"terminus":[37,261,278],"of":[38,54,85,109,115,178,185,207,237,250,290,313,328],"can":[40],"be":[41],"phosphorylated":[42,58,121,251,279,295],"at":[43,122],"tyrosine":[44],"125":[45],"serine":[47,318],"129,":[48],"although":[49],"only":[50],"a":[51,106,112,310],"small":[52,311],"fraction":[53],"is":[57,105,119,180,339],"under":[59],"normal":[60],"conditions":[61],"(Okochi,":[62],"M.,":[63,71,132,149],"Walter,":[64],"J.,":[65,78,140],"Koyama,":[66],"A.,":[67],"Nakajo,":[68],"S.,":[69,154,168],"Baba,":[70],"Iwatsubo,":[72],"T.,":[73,159],"Meijer,":[74],"L.,":[75,151],"Kahle,":[76],"P.":[77,153],"Haass,":[80],"C.":[81],"(2000)":[82],"Constitutive":[83],"phosphorylation":[84,206],"associated":[89],"alpha-synuclein.":[90,254],"J.":[91,125,131,144,175,194],"Biol.":[92,195],"Chem.":[93,196],"275,":[94],"390-397).":[95],"Under":[96],"pathological":[97,113,183],"conditions,":[98],"such":[99],"as":[100],"disease,":[103,117],"major":[107],"component":[108],"Lewy":[110,191,215],"bodies,":[111],"hallmark":[114],"mostly":[120],"Ser-129":[123,179,282],"(Anderson,":[124],"P.,":[126,145,164,171],"Walker,":[127],"D.":[128],"E.,":[129],"Goldstein,":[130],"de":[133],"Laat,":[134],"R.,":[135,142],"Banducci,":[136],"K.,":[137,147],"Caccavello,":[138],"R.":[139],"Barbour,":[141],"Huang,":[143],"Kling,":[146],"Lee,":[148],"Diep,":[150],"Keim,":[152],"Shen,":[155],"X.":[156],"F.,":[157],"Chataway,":[158],"Schlossmacher,":[160],"G.,":[162],"Seubert,":[163],"Schenk,":[165],"D.,":[166],"Sinha,":[167],"Gai,":[169],"W.":[170],"Chilcote,":[173],"T.":[174],"(2006)":[176],"Phosphorylation":[177],"dominant":[182],"modification":[184],"sporadic":[190],"body":[192],"281,":[197],"29739-29752).":[198],"Controversy":[199],"exists":[200],"over":[201],"extent":[203],"which":[205],"and/or":[209],"visible":[211],"aggregation":[213],"bodies":[216],"are":[217,222,225,334],"steps":[218],"pathogenesis,":[221],"protective,":[223],"or":[224,283],"neutral":[226],"markers":[227],"for":[228,270,325],"process.":[231],"Here":[232],"we":[233],"used":[234],"combination":[236],"peptide":[238],"pulldown":[239],"assays":[240],"mass":[242],"spectrometry":[243],"identify":[245],"compare":[247],"protein-protein":[248,329],"interactions":[249,330],"non-phosphorylated":[253,258],"We":[255],"showed":[256],"that":[257,266,332],"pulled":[262,292],"down":[263,293],"complexes":[265],"were":[267],"highly":[268,298],"enriched":[269,299],"mitochondrial":[271],"electron":[272],"transport":[273],"proteins,":[274,303,307],"whereas":[275],"on":[280],"either":[281],"Tyr-125":[284],"did":[285],"not.":[286],"Instead":[287],"set":[289],"proteins":[291],"by":[294],"was":[297],"certain":[301],"cytoskeletal":[302],"vesicular":[305],"trafficking":[306],"enzymes":[314],"involved":[315],"phosphorylation.":[319],"This":[320],"targeted":[321],"comparative":[322],"proteomics":[323],"approach":[324],"unbiased":[326],"identification":[327],"suggests":[331],"there":[333],"functional":[335],"consequences":[336],"when":[337],"phosphorylated.":[340]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":20}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
