{"id":"https://openalex.org/W2000296619","doi":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","title":"Relative efficiencies of the Chi\u2010square recombination models for gene mapping with human pedigree data","display_name":"Relative efficiencies of the Chi\u2010square recombination models for gene mapping with human pedigree data","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2000296619","doi":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","mag":"2000296619","pmid":"https://pubmed.ncbi.nlm.nih.gov/10738522"},"language":"en","primary_location":{"id":"doi:10.1046/j.1469-1809.1999.6310081.x","doi":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1469-1809.1999.6310081.x","source":{"id":"https://openalex.org/S131700781","display_name":"Annals of Human Genetics","issn_l":"0003-4800","issn":["0003-4800","1469-1809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1469-1809.1999.6310081.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. LIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. LIN","raw_affiliation_strings":["Department of Statistics, Ohio State University 43210-1247, USA","Department of Statistics, Ohio State University, OH 43210-1247 and Department of Statistics, University of California, Berkeley, CA 94720-3860"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Ohio State University 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, Ohio State University, OH 43210-1247 and Department of Statistics, University of California, Berkeley, CA 94720-3860","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001135422","display_name":"Terence Paul Speed","orcid":"https://orcid.org/0000-0002-5403-7998","observed_orcids":["https://orcid.org/0000-0002-5403-7998"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. P. SPEED","raw_affiliation_strings":["Department of Statistics, Ohio State University, OH 43210-1247 and Department of Statistics, University of California, Berkeley, CA 94720-3860"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Ohio State University, OH 43210-1247 and Department of Statistics, University of California, Berkeley, CA 94720-3860","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":null,"fwci":0.5233,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64620043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"63","issue":"1","first_page":"81","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.08299999684095383,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-pedigrees","display_name":"human pedigrees","score":0.7440000176429749},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.7360000014305115},{"id":"https://openalex.org/keywords/exclusion-mapping","display_name":"exclusion mapping","score":0.7870000004768372},{"id":"https://openalex.org/keywords/disease-gene-mapping","display_name":"disease gene mapping","score":0.6539999842643738},{"id":"https://openalex.org/keywords/simulation-study","display_name":"simulation study","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.8747695684432983},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.6255362033843994},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.5849524736404419},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5470243096351624},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.5070006847381592},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.46895211935043335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4536241888999939},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4196540117263794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36169081926345825},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36009010672569275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3294661045074463},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2737952470779419},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1469-1809.1999.6310081.x","doi":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1469-1809.1999.6310081.x","source":{"id":"https://openalex.org/S131700781","display_name":"Annals of Human Genetics","issn_l":"0003-4800","issn":["0003-4800","1469-1809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Human Genetics","raw_type":"journal-article"},{"id":"pmid:10738522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10738522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of human genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1469-1809.1999.6310081.x","doi":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1469-1809.1999.6310081.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1469-1809.1999.6310081.x","source":{"id":"https://openalex.org/S131700781","display_name":"Annals of Human Genetics","issn_l":"0003-4800","issn":["0003-4800","1469-1809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Human Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3066300280","display_name":"GENE MAPPING","funder_award_id":"5r01hg001093-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4041991896","display_name":null,"funder_award_id":"R01 HG01093-01","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000296619.pdf","grobid_xml":"https://content.openalex.org/works/W2000296619.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1538524809","https://openalex.org/W1760690168","https://openalex.org/W1839107686","https://openalex.org/W1854500750","https://openalex.org/W1933946532","https://openalex.org/W1991311566","https://openalex.org/W1998158007","https://openalex.org/W2017428806","https://openalex.org/W2081412393","https://openalex.org/W2094850537","https://openalex.org/W2151622611","https://openalex.org/W2170527944","https://openalex.org/W4230157089","https://openalex.org/W4404725644"],"related_works":["https://openalex.org/W2016258602","https://openalex.org/W1995215976","https://openalex.org/W2168570427","https://openalex.org/W2152800677","https://openalex.org/W2094850537","https://openalex.org/W2046386888","https://openalex.org/W2138378670","https://openalex.org/W2329729094","https://openalex.org/W1549470101","https://openalex.org/W2169925367"],"abstract_inverted_index":{"In":[0,61],"the":[1,9,18,47,50,57,63,78,96,119,125,149],"paper":[2],"by":[3],"Goldstein":[4,102],"et":[5,103],"al.":[6],"(Genomics,":[7],"1995),":[8],"authors":[10],"carried":[11],"out":[12],"a":[13,22,81],"simulation":[14],"study":[15,82],"to":[16,27,148,160],"investigate":[17],"relative":[19],"efficiencies":[20],"of":[21,59,65,80,153,175],"no":[23,51],"interference":[24,52,162],"linkage":[25,165],"analysis":[26,29,48],"an":[28],"with":[30,49,71,115,139],"certain":[31],"models":[32],"that":[33],"allow":[34],"for":[35,40,89,122,151],"interference.":[36,60],"They":[37],"showed":[38],"that,":[39],"completely":[41,66],"informative":[42,67,143],"and":[43,107,157],"independent":[44],"recombination":[45],"data,":[46,180],"model":[53,127],"was":[54],"inefficient,":[55],"in":[56,132,182],"present":[58],"practice,":[62],"assumption":[64],"markers":[68],"is":[69,136],"unrealistic":[70],"data":[72],"from":[73],"human":[74],"pedigrees.":[75,93],"We":[76,94],"report":[77],"results":[79,111,146],"investigating":[83],"whether":[84],"this":[85],"conclusion":[86],"still":[87],"holds":[88],"gametes":[90],"arising":[91],"within":[92],"consider":[95],"same":[97],"two":[98],"mapping":[99,106,166],"problems":[100],"as":[101,130],"al.:":[104],"exclusion":[105],"gene":[108,184],"ordering.":[109],"The":[110],"obtained":[112],"were":[113,128],"consistent":[114],"their":[116],"findings,":[117],"although":[118],"efficiency":[120],"gains":[121],"analyses":[123],"using":[124,167],"chi-square":[126],"not":[129,137],"great":[131],"some":[133],"cases.":[134],"This":[135,170],"unexpected":[138],"less":[140],"than":[141],"fully":[142],"data.":[144,169],"These":[145],"point":[147],"need":[150],"research":[152],"developing":[154],"new":[155],"statistical":[156],"computational":[158],"methods":[159],"incorporate":[161],"into":[163],"multipoint":[164],"pedigree":[168],"would":[171],"make":[172],"efficient":[173],"use":[174],"available,":[176],"but":[177],"sometimes":[178],"scarce":[179],"especially":[181],"disease":[183],"mapping.":[185]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
