{"id":"https://openalex.org/W2000284836","doi":"https://doi.org/10.1093/hmg/ddu391","title":"The small GTPase Rab11 co-localizes with -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity","display_name":"The small GTPase Rab11 co-localizes with -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity","publication_year":2014,"publication_date":"2014-08-04","ids":{"openalex":"https://openalex.org/W2000284836","doi":"https://doi.org/10.1093/hmg/ddu391","mag":"2000284836","pmid":"https://pubmed.ncbi.nlm.nih.gov/25092884"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddu391","doi":"https://doi.org/10.1093/hmg/ddu391","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddu391","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/The_small_GTPase_Rab11_co-localizes_with_-synuclein_in_intracellular_inclusions_and_modulates_its_aggregation_secretion_and_toxicity/10162241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018079819","display_name":"Oldriska Chutna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"O. Chutna","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020798178","display_name":"Susana A. Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-8025-2624","observed_orcids":["https://orcid.org/0000-0002-8025-2624"]},"institutions":[{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"S. Goncalves","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090998741","display_name":"Anna Villar\u2010Piqu\u00e9","orcid":"https://orcid.org/0000-0002-5528-208X","observed_orcids":["https://orcid.org/0000-0002-5528-208X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210129011","display_name":"Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 \u2014 DFG Research Center 103","ror":"https://ror.org/02wkzzr31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129011"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Villar-Pique","raw_affiliation_strings":["Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210129011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035210234","display_name":"Patr\u00edcia Silva Guerreiro","orcid":"https://orcid.org/0000-0002-0948-043X","observed_orcids":["https://orcid.org/0000-0002-0948-043X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210129011","display_name":"Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 \u2014 DFG Research Center 103","ror":"https://ror.org/02wkzzr31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129011"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["DE","PT"],"is_corresponding":false,"raw_author_name":"P. Guerreiro","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210129011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069643355","display_name":"Zrinka Marijanovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Z. Marijanovic","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082207076","display_name":"Tiago Mendes","orcid":"https://orcid.org/0000-0002-6194-7295","observed_orcids":["https://orcid.org/0000-0002-6194-7295"]},"institutions":[{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"T. Mendes","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043485685","display_name":"Jose Silva Ramalho","orcid":"https://orcid.org/0000-0002-1927-164X","observed_orcids":["https://orcid.org/0000-0002-1927-164X"]},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J. Ramalho","raw_affiliation_strings":["CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039096817","display_name":"Evangelia Emmanouilidou","orcid":"https://orcid.org/0000-0003-3106-8270","observed_orcids":["https://orcid.org/0000-0003-3106-8270"]},"institutions":[{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Emmanouilidou","raw_affiliation_strings":["Biomedical Research Foundation of the Academy of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Foundation of the Academy of Athens, Athens, Greece","institution_ids":["https://openalex.org/I4210093138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025858582","display_name":"Salvador Ventura","orcid":"https://orcid.org/0000-0002-9652-6351","observed_orcids":["https://orcid.org/0000-0002-9652-6351"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Ventura","raw_affiliation_strings":["Institut de Biotecnologia i Biomedicina Departament de Bioquimica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain","Departament de Bioquimica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain","Institut de Biotecnologia i Biomedicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biotecnologia i Biomedicina Departament de Bioquimica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Departament de Bioquimica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Institut de Biotecnologia i Biomedicina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066832631","display_name":"Jochen Klucken","orcid":"https://orcid.org/0000-0001-6645-9437","observed_orcids":["https://orcid.org/0000-0001-6645-9437","https://orcid.org/0000-0002-5306-920X"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Klucken","raw_affiliation_strings":["Department of Molecular Neurology, University Hospital, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurology, University Hospital, Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051367903","display_name":"Duarte C. Barral","orcid":"https://orcid.org/0000-0001-8867-2407","observed_orcids":["https://orcid.org/0000-0001-8867-2407"]},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"D. C. Barral","raw_affiliation_strings":["CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036156104","display_name":"Flaviano Giorgini","orcid":"https://orcid.org/0000-0001-7881-9508","observed_orcids":["https://orcid.org/0000-0001-7881-9508"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Giorgini","raw_affiliation_strings":["Department of Genetics, University of Leicester, University Road, Leicester, UK and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Leicester, University Road, Leicester, UK and","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019613030","display_name":"Kostas Vekrellis","orcid":"https://orcid.org/0000-0001-5702-9953","observed_orcids":["https://orcid.org/0000-0001-5702-9953"]},"institutions":[{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Vekrellis","raw_affiliation_strings":["Biomedical Research Foundation of the Academy of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Foundation of the Academy of Athens, Athens, Greece","institution_ids":["https://openalex.org/I4210093138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014020587","display_name":"Tiago F. Outeiro","orcid":"https://orcid.org/0000-0003-1679-1727","observed_orcids":["https://orcid.org/0000-0003-1679-1727"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210129011","display_name":"Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 \u2014 DFG Research Center 103","ror":"https://ror.org/02wkzzr31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129011"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE","PT"],"is_corresponding":true,"raw_author_name":"T. F. Outeiro","raw_affiliation_strings":["Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal tiago.outeiro@med.uni-goettingen.de","Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal tiago.outeiro@med.uni-goettingen.de","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210116730","https://openalex.org/I4392738257","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon, Portugal","institution_ids":["https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Department of Neurodegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I4210129011"]},{"raw_affiliation_string":"Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5014020587"],"corresponding_institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210116730","https://openalex.org/I4210129011","https://openalex.org/I4392738257","https://openalex.org/I74656192"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":5.7014,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.96567214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"25","first_page":"6732","last_page":"6745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab11","display_name":"Rab11","score":0.9729999899864197},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.9369999766349792},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.7639999985694885},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intracellular-inclusions","display_name":"intracellular inclusions","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.621999979019165},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.4869999885559082},{"id":"https://openalex.org/keywords/cell-to-cell-spread","display_name":"cell-to-cell transmission","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7120329737663269},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7038439512252808},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.6801483631134033},{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.6425976753234863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6304776668548584},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5957222580909729},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5750178098678589},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.5433095693588257},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5216936469078064},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.4186874032020569},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4157983362674713},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26811739802360535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2555215656757355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14333704113960266},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.11700043082237244},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10704365372657776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07742035388946533},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.07074856758117676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099193","descriptor_name":"rab11 GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1093/hmg/ddu391","doi":"https://doi.org/10.1093/hmg/ddu391","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddu391","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:25092884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25092884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029205579","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-74604","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"pmh:oai:figshare.com:article/10162241","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_small_GTPase_Rab11_co-localizes_with_-synuclein_in_intracellular_inclusions_and_modulates_its_aggregation_secretion_and_toxicity/10162241","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:lra.le.ac.uk:2381/37314","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/37314","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/31480","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/31480","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.ulisboa.pt:10451/51869","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10451/51869","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:ub.uni-erlangen.de-opus:7460","doi":null,"is_oa":false,"landing_page_url":"https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/7460","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"doi:10.25405/ncl.34342866","doi":"https://doi.org/10.25405/ncl.34342866","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34342866","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34342866.v1","doi":"https://doi.org/10.25405/ncl.34342866.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34342866.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10162241","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_small_GTPase_Rab11_co-localizes_with_-synuclein_in_intracellular_inclusions_and_modulates_its_aggregation_secretion_and_toxicity/10162241","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8668851349","display_name":null,"funder_award_id":"G-1203","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"}],"funders":[{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1517181973","https://openalex.org/W1588992473","https://openalex.org/W1822935226","https://openalex.org/W1835592430","https://openalex.org/W1966409098","https://openalex.org/W1974924674","https://openalex.org/W1977267085","https://openalex.org/W1978989017","https://openalex.org/W1979786105","https://openalex.org/W1985542464","https://openalex.org/W1985811626","https://openalex.org/W1986259776","https://openalex.org/W1986739850","https://openalex.org/W1987390440","https://openalex.org/W1990346703","https://openalex.org/W1992258525","https://openalex.org/W1994668150","https://openalex.org/W1995191747","https://openalex.org/W1996679985","https://openalex.org/W1997524825","https://openalex.org/W2030725090","https://openalex.org/W2036203077","https://openalex.org/W2038640606","https://openalex.org/W2040462263","https://openalex.org/W2046885195","https://openalex.org/W2050647292","https://openalex.org/W2050786534","https://openalex.org/W2052029497","https://openalex.org/W2055652883","https://openalex.org/W2060272083","https://openalex.org/W2061195883","https://openalex.org/W2065236536","https://openalex.org/W2068001820","https://openalex.org/W2070575993","https://openalex.org/W2073449985","https://openalex.org/W2075906033","https://openalex.org/W2084234612","https://openalex.org/W2085530286","https://openalex.org/W2089900719","https://openalex.org/W2096956734","https://openalex.org/W2105488386","https://openalex.org/W2108060249","https://openalex.org/W2121354606","https://openalex.org/W2123869107","https://openalex.org/W2129146981","https://openalex.org/W2130323165","https://openalex.org/W2131409719","https://openalex.org/W2145206503","https://openalex.org/W2152254886","https://openalex.org/W2157102136","https://openalex.org/W2158674432","https://openalex.org/W2161334375","https://openalex.org/W2162565534","https://openalex.org/W2167221791","https://openalex.org/W2167721936","https://openalex.org/W2169735361"],"related_works":["https://openalex.org/W2343636827","https://openalex.org/W2438674992","https://openalex.org/W2162360946","https://openalex.org/W3021154796","https://openalex.org/W3102606191","https://openalex.org/W2885329575","https://openalex.org/W2908447393","https://openalex.org/W2035319572","https://openalex.org/W4284993931","https://openalex.org/W6887692535"],"abstract_inverted_index":{"Alpha-synuclein":[0],"(aSyn)":[1],"misfolding":[2],"and":[3,25,35,51,93,107,123,139],"aggregation":[4,106],"are":[5,128],"pathological":[6,38],"features":[7],"common":[8],"to":[9,29],"several":[10],"neurodegenerative":[11],"diseases,":[12],"including":[13],"Parkinson's":[14],"disease":[15],"(PD).":[16],"Mounting":[17],"evidence":[18],"suggests":[19],"that":[20,57,88,112],"aSyn":[21,63,92,105,121,135],"can":[22],"be":[23],"secreted":[24],"transferred":[26],"from":[27],"cell":[28],"cell,":[30],"participating":[31],"in":[32,48,61,96,116,131,137],"the":[33,118,132],"propagation":[34],"spreading":[36],"of":[37,69,83,120,126,134],"events.":[39],"Rab11,":[40],"a":[41],"small":[42],"GTPase,":[43],"is":[44,59,94,114],"an":[45],"important":[46,129],"regulator":[47],"both":[49,125],"endocytic":[50],"secretory":[52],"pathways.":[53],"Here,":[54],"we":[55,86],"show":[56],"Rab11":[58,65,89,103,113],"involved":[60,115],"regulating":[62],"secretion.":[64],"knockdown":[66],"or":[67,75],"overexpression":[68],"either":[70],"Rab11a":[71,76],"wild-type":[72],"(Rab11a":[73,79],"WT)":[74],"GDP-bound":[77],"mutant":[78],"S25N)":[80],"increased":[81],"secretion":[82,122],"aSyn.":[84,101],"Furthermore,":[85],"demonstrate":[87],"interacts":[90],"with":[91,100],"present":[95],"intracellular":[97],"inclusions":[98],"together":[99],"Moreover,":[102],"reduces":[104],"toxicity.":[108],"Our":[109],"results":[110],"suggest":[111],"modulating":[117],"processes":[119],"aggregation,":[124],"which":[127],"mechanisms":[130],"progression":[133],"pathology":[136],"PD":[138],"other":[140],"synucleinopathies.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
