{"id":"https://openalex.org/W2000277154","doi":"https://doi.org/10.1001/archpsyc.1981.01780310031002","title":"Monoamine Metabolites in CSF and Suicidal Behavior","display_name":"Monoamine Metabolites in CSF and Suicidal Behavior","publication_year":1981,"publication_date":"1981-06-01","ids":{"openalex":"https://openalex.org/W2000277154","doi":"https://doi.org/10.1001/archpsyc.1981.01780310031002","mag":"2000277154","pmid":"https://pubmed.ncbi.nlm.nih.gov/6166274"},"language":"en","primary_location":{"id":"doi:10.1001/archpsyc.1981.01780310031002","doi":"https://doi.org/10.1001/archpsyc.1981.01780310031002","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1981.01780310031002","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045053759","display_name":"Lil Tr\u00e4skman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lil Tr\u00e4skman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045053759"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":39.8132,"has_fulltext":false,"cited_by_count":689,"citation_normalized_percentile":{"value":0.99944259,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"38","issue":"6","first_page":"631","last_page":"631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-metabolites","display_name":"monoamine metabolites","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9350000023841858},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.6039999723434448},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9470000267028809},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/mhpg","display_name":"MHPG","score":0.9819999933242798},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9079999923706055},{"id":"https://openalex.org/keywords/suicide-mortality","display_name":"suicide mortality","score":0.703000009059906},{"id":"https://openalex.org/keywords/neurochemical-markers","display_name":"neurochemical markers","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2775841634","wikidata":"https://www.wikidata.org/wiki/Q903566","display_name":"Homovanillic acid","level":4,"score":0.9318681359291077},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7981996536254883},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7626452445983887},{"id":"https://openalex.org/C2780066322","wikidata":"https://www.wikidata.org/wiki/Q719444","display_name":"Lumbar puncture","level":3,"score":0.679682195186615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5002083778381348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4917038083076477},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.45774194598197937},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.436147540807724},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.42267730832099915},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3880422115325928},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38614070415496826},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.37384033203125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3498621881008148},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.29759812355041504},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09173700213432312},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.06872951984405518},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006018","descriptor_name":"Glycols","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006018","descriptor_name":"Glycols","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006018","descriptor_name":"Glycols","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D013405","descriptor_name":"Suicide","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013405","descriptor_name":"Suicide","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013405","descriptor_name":"Suicide","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archpsyc.1981.01780310031002","doi":"https://doi.org/10.1001/archpsyc.1981.01780310031002","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archpsyc.1981.01780310031002","pdf_url":null,"source":{"id":"https://openalex.org/S126359496","display_name":"Archives of General Psychiatry","issn_l":"0003-990X","issn":["0003-990X","1538-3636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of General Psychiatry","raw_type":"journal-article"},{"id":"pmid:6166274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6166274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of general psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W26453693","https://openalex.org/W64096637","https://openalex.org/W184374761","https://openalex.org/W378684521","https://openalex.org/W1682676837","https://openalex.org/W1964792484","https://openalex.org/W1967908420","https://openalex.org/W1969993743","https://openalex.org/W1972662794","https://openalex.org/W1977036953","https://openalex.org/W1977294562","https://openalex.org/W1979217475","https://openalex.org/W1985975970","https://openalex.org/W1990302721","https://openalex.org/W1990946372","https://openalex.org/W1991735971","https://openalex.org/W2000611966","https://openalex.org/W2006851386","https://openalex.org/W2008150716","https://openalex.org/W2008431798","https://openalex.org/W2008531739","https://openalex.org/W2011089108","https://openalex.org/W2014695884","https://openalex.org/W2016371873","https://openalex.org/W2018439671","https://openalex.org/W2018840838","https://openalex.org/W2030711496","https://openalex.org/W2030998472","https://openalex.org/W2035152097","https://openalex.org/W2035936600","https://openalex.org/W2036312254","https://openalex.org/W2043370233","https://openalex.org/W2058342307","https://openalex.org/W2060143950","https://openalex.org/W2061541290","https://openalex.org/W2068237121","https://openalex.org/W2080453038","https://openalex.org/W2080889861","https://openalex.org/W2081371398","https://openalex.org/W2090040371","https://openalex.org/W2092732050","https://openalex.org/W2092837465","https://openalex.org/W2093159595","https://openalex.org/W2094109562","https://openalex.org/W2094700723","https://openalex.org/W2105500530","https://openalex.org/W2105758627","https://openalex.org/W2121843306","https://openalex.org/W2129132384","https://openalex.org/W2131823335","https://openalex.org/W2134996183","https://openalex.org/W2141489294","https://openalex.org/W2142520629","https://openalex.org/W2144055043","https://openalex.org/W2149414494","https://openalex.org/W2161457683","https://openalex.org/W2200560545","https://openalex.org/W2257424174","https://openalex.org/W2266575735","https://openalex.org/W2285368991","https://openalex.org/W2406150846","https://openalex.org/W2411221764","https://openalex.org/W2415273132","https://openalex.org/W2421741627","https://openalex.org/W2427053337"],"related_works":["https://openalex.org/W17887401","https://openalex.org/W2364842670","https://openalex.org/W2067322948","https://openalex.org/W2379809596","https://openalex.org/W3169790471","https://openalex.org/W2101269099","https://openalex.org/W2127398542","https://openalex.org/W2134791325","https://openalex.org/W3000248037","https://openalex.org/W2060359473"],"abstract_inverted_index":{"Cerebrospinal":[0],"fluid":[1],"concentrations":[2],"of":[3,75,94,109],"the":[4,42,65,92,104,137],"monoamine":[5],"metabolites":[6],"5-hydroxyindoleacetic":[7],"acid":[8,11],"(5-HIAA),":[9],"homovanillic":[10],"(HVA),":[12],"and":[13,27,59,63,111],"3-methoxy-4-hydroxyphenyl":[14],"glycol":[15],"(MHPG)":[16],"were":[17,78,86,100],"measured":[18],"in":[19,56,67,82,103,130],"30":[20],"psychiatric":[21],"patients":[22,84,114,131],"who":[23,46,85],"had":[24,34,47],"attempted":[25],"suicide":[26,32,123],"45":[28],"healthy":[29],"volunteers.":[30],"The":[31],"attempters":[33],"a":[35,119,125,133],"significantly":[36],"lower":[37,79],"CSF":[38],"5-HIAA":[39,68,76],"level":[40,69,135],"than":[41,80],"controls,":[43],"especially":[44],"those":[45],"made":[48],"more":[49,72,113],"violent":[50],"attempts.":[51],"After":[52],"adjustment":[53],"for":[54],"differences":[55],"body":[57],"height":[58],"age":[60],"between":[61],"controls":[62],"patients,":[64],"difference":[66],"became":[70],"even":[71],"marked.":[73],"Concentrations":[74],"also":[77],"normal":[81],"suicidal":[83],"not":[87],"diagnosed":[88],"as":[89],"depressed":[90],"at":[91],"time":[93],"lumbar":[95,128],"puncture,":[96],"while":[97],"HVA":[98],"levels":[99],"lowered":[101],"only":[102],"depressives.":[105],"A":[106],"follow-up":[107],"study":[108],"these":[110],"89":[112],"(depressed":[115],"and/or":[116],"suicidal)":[117],"revealed":[118],"20%":[120],"mortality":[121],"by":[122],"within":[124],"year":[126],"after":[127],"puncture":[129],"with":[132],"CSF-HIAA":[134],"below":[136],"median.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}