{"id":"https://openalex.org/W200027121","doi":null,"title":"Linoleic acid lowers LDL cholesterol without a proportionate displacement of saturated fatty acid.","display_name":"Linoleic acid lowers LDL cholesterol without a proportionate displacement of saturated fatty acid.","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W200027121","mag":"200027121","pmid":"https://pubmed.ncbi.nlm.nih.gov/1915205"},"language":"en","primary_location":{"id":"pmid:1915205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1915205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical nutrition","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G Rassias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I4210101388","display_name":"Health Sciences and Nutrition","ror":"https://ror.org/0152bt112","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210101388","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G Rassias","raw_affiliation_strings":["CSIRO Division of Human Nutrition, Adelaide, South Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIRO Division of Human Nutrition, Adelaide, South Australia","institution_ids":["https://openalex.org/I1292875679","https://openalex.org/I4210101388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075666233","display_name":"Mark Kestin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kestin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071175023","display_name":"P. J. Nestel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Nestel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7882,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.87780334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"45","issue":"6","first_page":"315","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":1.0},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.859000027179718},{"id":"https://openalex.org/keywords/dietary-fat-composition","display_name":"dietary fat composition","score":0.6010000109672546},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.5299999713897705},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/monounsaturated-fatty-acids","display_name":"monounsaturated fatty acids","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.8241997957229614},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7187193632125854},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.590275764465332},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5895573496818542},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5453800559043884},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5222695469856262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5208690166473389},{"id":"https://openalex.org/C3020261727","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fat","level":3,"score":0.5082518458366394},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.460290789604187},{"id":"https://openalex.org/C2780516434","wikidata":"https://www.wikidata.org/wiki/Q127980","display_name":"Polyunsaturated fat","level":4,"score":0.41026633977890015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3582346439361572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34177643060684204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2617499828338623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25823938846588135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21628880500793457}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1915205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1915205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical nutrition","raw_type":"Clinical Trial"},{"id":"mag:200027121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1915205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7018973117","https://openalex.org/W2395747245","https://openalex.org/W1937372757","https://openalex.org/W1987088070","https://openalex.org/W2001397244","https://openalex.org/W1853850926","https://openalex.org/W1977330916","https://openalex.org/W2139507831","https://openalex.org/W2047102295","https://openalex.org/W2261642730"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,5,29,53,58,70,77,140],"specificity":[3],"of":[4,9,15,116],"plasma":[6,90],"cholesterol-lowering":[7],"effect":[8],"linoleic":[10,47],"acid":[11,63,164],"in":[12,36,73,121],"a":[13,37,42,127],"comparison":[14],"linoleate-rich":[16,78],"and":[17,26,60,92,100,156,177],"saturated":[18,59,132,170],"fatty":[19,62,86,133,171],"acid-rich":[20,48,142],"foods.":[21],"Twelve":[22],"mildly":[23],"hypercholesterolemic":[24],"men":[25],"women":[27],"ate":[28],"two":[30],"diets":[31],"for":[32],"three":[33],"weeks":[34],"each":[35],"random":[38],"cross-over":[39],"design,":[40],"after":[41],"two-week":[43],"baseline":[44,54],"period.":[45],"A":[46],"supplement":[49,128],"was":[50,119],"added":[51],"to":[52,135],"diet":[55,79,143],"so":[56],"that":[57,129],"monounsaturated":[61],"content":[64],"did":[65],"not":[66,174],"change":[67],"significantly.":[68],"Despite":[69],"consequent":[71],"increase":[72],"total":[74,91,146],"fat":[75],"intake,":[76],"(23":[80],"per":[81,98,102,112,137,149,154,160],"cent":[82,99,103,138],"energy":[83],"from":[84],"polyunsaturated":[85],"acids)":[87],"significantly":[88,175],"lowered":[89],"low-density":[93],"lipoprotein":[94,107],"(LDL)":[95],"cholesterol":[96,109,147,152,158,167],"(-8":[97],"-14":[101],"respectively),":[104],"while":[105],"high-density":[106],"(HDL)":[108],"rose":[110],"8":[111],"cent.":[113],"The":[114],"direction":[115],"these":[117],"changes":[118],"similar":[120],"all":[122],"12":[123],"subjects.":[124],"Compared":[125],"with":[126],"raised":[130],"dietary":[131],"acids":[134,172],"30":[136],"energy,":[139],"linoleate":[141],"gave":[144],"lower":[145],"(-14":[148],"cent),":[150],"LDL":[151,166],"(-18":[153],"cent)":[155,161],"HDL":[157],"(-12":[159],"concentrations.":[162],"Linoleic":[163],"lowers":[165],"even":[168],"when":[169,180],"are":[173],"displaced":[176],"substantially":[178],"more":[179],"there":[181],"is":[182],"such":[183],"displacement.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}