{"id":"https://openalex.org/W2000263240","doi":"https://doi.org/10.1074/jbc.m111.254797","title":"Identification of Integrin \u03b2 Subunit Mutations That Alter Affinity for Extracellular Matrix Ligand","display_name":"Identification of Integrin \u03b2 Subunit Mutations That Alter Affinity for Extracellular Matrix Ligand","publication_year":2011,"publication_date":"2011-07-12","ids":{"openalex":"https://openalex.org/W2000263240","doi":"https://doi.org/10.1074/jbc.m111.254797","mag":"2000263240","pmid":"https://pubmed.ncbi.nlm.nih.gov/21757698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3162457"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.254797","doi":"https://doi.org/10.1074/jbc.m111.254797","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.254797","pdf_url":"http://www.jbc.org/article/S0021925820723793/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820723793/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024369594","display_name":"Timmy L. Kendall","orcid":"https://orcid.org/0000-0003-3519-9673","observed_orcids":["https://orcid.org/0000-0003-3519-9673"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timmy Kendall","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079219065","display_name":"Leona Mukai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leona Mukai","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064438446","display_name":"Alison L. Jannuzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison L. Jannuzi","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000590974","display_name":"Thomas A. Bunch","orcid":"https://orcid.org/0000-0002-6237-1427","observed_orcids":["https://orcid.org/0000-0002-6237-1427"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas A. Bunch","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724. Electronic address: tbunch@email.arizona.edu","Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724. Electronic address:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724. Electronic address: tbunch@email.arizona.edu","institution_ids":["https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Arizona Cancer Center, Tucson, Arizona 85724. Electronic address:","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000590974"],"corresponding_institution_ids":["https://openalex.org/I4390039223"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.1426,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85155499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"286","issue":"35","first_page":"30981","last_page":"30993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cd-loop","display_name":"CD loop","score":0.7839999794960022},{"id":"https://openalex.org/keywords/i-domain","display_name":"I-domain","score":0.6150000095367432},{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.6890000104904175},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7250000238418579},{"id":"https://openalex.org/keywords/conditional-lethality","display_name":"conditional lethality","score":0.6629999876022339},{"id":"https://openalex.org/keywords/genetic-interactions","display_name":"genetic interactions","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.875930666923523},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8530319929122925},{"id":"https://openalex.org/C4894155","wikidata":"https://www.wikidata.org/wiki/Q4201950","display_name":"CD49c","level":5,"score":0.7730621695518494},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.6019856929779053},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.577125072479248},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.559586226940155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5507680773735046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47773855924606323},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4548746347427368},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4283202886581421},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41939225792884827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3364379405975342},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25066709518432617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11794522404670715}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016608","descriptor_name":"Talin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039001","descriptor_name":"Integrin alpha Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039641","descriptor_name":"Integrin beta Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m111.254797","doi":"https://doi.org/10.1074/jbc.m111.254797","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.254797","pdf_url":"http://www.jbc.org/article/S0021925820723793/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3162457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3162457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21757698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21757698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.254797","doi":"https://doi.org/10.1074/jbc.m111.254797","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.254797","pdf_url":"http://www.jbc.org/article/S0021925820723793/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G223908282","display_name":"Structure/Function Studies of the Integrin","funder_award_id":"R01GM042474","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2277093813","display_name":null,"funder_award_id":"CA-023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5231822823","display_name":null,"funder_award_id":"023074","funder_id":"https://openalex.org/F4320309707","funder_display_name":"University of Arizona Cancer Center"},{"id":"https://openalex.org/G9000909272","display_name":"University of Arizona Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309707","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000263240.pdf","grobid_xml":"https://content.openalex.org/works/W2000263240.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1500795239","https://openalex.org/W1501066791","https://openalex.org/W1506821897","https://openalex.org/W1576773659","https://openalex.org/W1590595696","https://openalex.org/W1605923556","https://openalex.org/W1901040110","https://openalex.org/W1918827074","https://openalex.org/W1931265512","https://openalex.org/W1938388466","https://openalex.org/W1964681919","https://openalex.org/W1965782511","https://openalex.org/W1982398946","https://openalex.org/W1985520699","https://openalex.org/W1990842021","https://openalex.org/W1994350857","https://openalex.org/W1997636752","https://openalex.org/W1998072224","https://openalex.org/W1999012520","https://openalex.org/W2016464728","https://openalex.org/W2019065906","https://openalex.org/W2020819434","https://openalex.org/W2022168758","https://openalex.org/W2026804025","https://openalex.org/W2030486875","https://openalex.org/W2033202813","https://openalex.org/W2039838953","https://openalex.org/W2044882848","https://openalex.org/W2045984211","https://openalex.org/W2048890479","https://openalex.org/W2052276663","https://openalex.org/W2060432010","https://openalex.org/W2066682264","https://openalex.org/W2067836657","https://openalex.org/W2068453204","https://openalex.org/W2071831930","https://openalex.org/W2074326074","https://openalex.org/W2082328100","https://openalex.org/W2090659127","https://openalex.org/W2092447350","https://openalex.org/W2094469836","https://openalex.org/W2096477148","https://openalex.org/W2101659312","https://openalex.org/W2109267411","https://openalex.org/W2111778285","https://openalex.org/W2120294554","https://openalex.org/W2121278567","https://openalex.org/W2121721963","https://openalex.org/W2139671009","https://openalex.org/W2141643986","https://openalex.org/W2145680582","https://openalex.org/W2147748470","https://openalex.org/W2154378559","https://openalex.org/W2154622534","https://openalex.org/W2156293127","https://openalex.org/W2158438551","https://openalex.org/W2162505358","https://openalex.org/W2163282731","https://openalex.org/W2165751778","https://openalex.org/W2171187567","https://openalex.org/W2175548625","https://openalex.org/W2177647639","https://openalex.org/W2334389786","https://openalex.org/W2442544949","https://openalex.org/W2472025011","https://openalex.org/W3111118831","https://openalex.org/W4366734294","https://openalex.org/W6818781500"],"related_works":["https://openalex.org/W2158438551","https://openalex.org/W2121721963","https://openalex.org/W2147748470","https://openalex.org/W2016813887","https://openalex.org/W7097546190","https://openalex.org/W1988585516","https://openalex.org/W2079947859","https://openalex.org/W2031003711","https://openalex.org/W1987148593","https://openalex.org/W1927041319"],"abstract_inverted_index":{"We":[0],"examined":[1],"over":[2],"50":[3],"mutations":[4,55,118,171],"in":[5,15,39,81,85,101,112,119,150,157,174,185,202,205,210],"the":[6,31,40,43,48,57,63,76,83,93,98,102,109,113,120,142,161,169,180,206],"Drosophila":[7],"\u03b2PS":[8,124,170],"integrin":[9,13,58,66,77,84,181,196,208],"subunit":[10],"that":[11,165,198],"alter":[12],"function":[14,176],"situ":[16],"for":[17,36,136,141],"their":[18],"ability":[19,46],"to":[20,107],"bind":[21],"a":[22,86,145],"soluble":[23],"monovalent":[24],"ligand,":[25],"TWOW-1.":[26],"Surprisingly,":[27],"very":[28],"few":[29],"of":[30,47,54,65,123,168],"mutations,":[32],"which":[33],"were":[34],"selected":[35],"conditional":[37],"lethality":[38],"fly,":[41,162],"reduce":[42],"ligand":[44,131],"binding":[45,132],"integrin.":[49],"The":[50],"most":[51],"prevalent":[52],"class":[53],"activates":[56],"heterodimer.":[59],"These":[60],"findings":[61],"emphasize":[62],"importance":[64],"affinity":[67,88,158,182,203],"regulation":[68],"and":[69,125,139,194],"point":[70],"out":[71],"how":[72],"molecular":[73],"interactions":[74,167,190],"throughout":[75],"molecule":[78],"are":[79,177],"important":[80,156],"keeping":[82],"low":[87],"state.":[89],"Mutations":[90],"strongly":[91],"support":[92],"controversial":[94],"deadbolt":[95],"hypothesis,":[96],"where":[97],"CD":[99],"loop":[100],"\u03b2":[103],"tail":[104],"domain":[105,111],"acts":[106],"restrain":[108],"I":[110],"inactive,":[114],"bent":[115],"conformation.":[116],"Site-directed":[117],"cytoplasmic":[121,146],"domains":[122],"\u03b1PS2C":[126],"reveal":[127],"different":[128],"effects":[129],"on":[130,192],"from":[133],"those":[134],"observed":[135],"\u03b1IIb\u03b23":[137],"integrins":[138],"identify":[140],"first":[143],"time":[144],"cysteine":[147],"residue,":[148],"conserved":[149],"three":[151],"human":[152],"integrins,":[153],"as":[154],"being":[155],"regulation.":[159],"In":[160],"we":[163],"find":[164],"genetic":[166,189],"with":[172,179],"reduction":[173],"talin":[175],"consistent":[178],"differences":[183],"measured":[184,209],"cells.":[186,212],"Additionally,":[187],"these":[188],"report":[191],"increased":[193],"decreased":[195],"functions":[197],"do":[199],"not":[200],"result":[201],"changes":[204],"PS2C":[207],"cultured":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}