{"id":"https://openalex.org/W2000259660","doi":"https://doi.org/10.1016/j.ijpharm.2014.11.063","title":"Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation","display_name":"Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation","publication_year":2014,"publication_date":"2014-11-29","ids":{"openalex":"https://openalex.org/W2000259660","doi":"https://doi.org/10.1016/j.ijpharm.2014.11.063","mag":"2000259660","pmid":"https://pubmed.ncbi.nlm.nih.gov/25450477"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2014.11.063","doi":"https://doi.org/10.1016/j.ijpharm.2014.11.063","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2014.11.063","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066388393","display_name":"Adele Patterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adele Patterson","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK. Electronic address: adele.patterson@bms.com","Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK. Electronic address: adele.patterson@bms.com","institution_ids":["https://openalex.org/I4210125795"]},{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085765854","display_name":"Ana Patr\u00edcia Ferreira","orcid":"https://orcid.org/0000-0001-7112-2126","observed_orcids":["https://orcid.org/0000-0001-7112-2126"]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana P. Ferreira","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091444141","display_name":"Elizabeth C. Banks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Banks","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050437774","display_name":"Kirsty Skeene","orcid":"https://orcid.org/0000-0002-7426-7352","observed_orcids":["https://orcid.org/0000-0002-7426-7352"]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirsty Skeene","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Graham Clarke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham Clarke","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109965675","display_name":"Sarah J. Nicholson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Nicholson","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044063578","display_name":"Clare Frances Rawlinson-Malone","orcid":"https://orcid.org/0000-0002-1613-1457","observed_orcids":["https://orcid.org/0000-0002-1613-1457"]},"institutions":[{"id":"https://openalex.org/I4210125795","display_name":"Bristol-Myers Squibb (United Kingdom)","ror":"https://ror.org/03emf1n04","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4210125795"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Rawlinson-Malone","raw_affiliation_strings":["Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK","institution_ids":["https://openalex.org/I4210125795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210125795"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.4343,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75469204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"478","issue":"1","first_page":"348","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-degradation","display_name":"drug degradation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/spray-drying","display_name":"spray drying","score":0.7760000228881836},{"id":"https://openalex.org/keywords/polymer-dispersions","display_name":"polymer dispersions","score":0.828000009059906},{"id":"https://openalex.org/keywords/amorphous-drug-delivery","display_name":"amorphous drug delivery","score":0.6930000185966492},{"id":"https://openalex.org/keywords/modified-arrhenius-equation","display_name":"modified Arrhenius equation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hpmcas","display_name":"HPMCAS","score":0.9810000061988831},{"id":"https://openalex.org/keywords/degree-of-substitution","display_name":"degree of substitution","score":0.6600000262260437},{"id":"https://openalex.org/keywords/storage-stability","display_name":"storage stability","score":0.6140000224113464},{"id":"https://openalex.org/keywords/temperature-and-humidity-effects","display_name":"temperature and humidity effects","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chemical-stability","display_name":"chemical stability","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C86183883","wikidata":"https://www.wikidata.org/wiki/Q507505","display_name":"Arrhenius equation","level":3,"score":0.6876207590103149},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6324812173843384},{"id":"https://openalex.org/C158960510","wikidata":"https://www.wikidata.org/wiki/Q180600","display_name":"Relative humidity","level":2,"score":0.6251261234283447},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.6204365491867065},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.5858852863311768},{"id":"https://openalex.org/C195702682","wikidata":"https://www.wikidata.org/wiki/Q623318","display_name":"Recrystallization (geology)","level":2,"score":0.5529777407646179},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.5313552021980286},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5137728452682495},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5135650634765625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.467360258102417},{"id":"https://openalex.org/C151420433","wikidata":"https://www.wikidata.org/wiki/Q180600","display_name":"Humidity","level":2,"score":0.46369683742523193},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4449404180049896},{"id":"https://openalex.org/C186399102","wikidata":"https://www.wikidata.org/wiki/Q903517","display_name":"Chemical stability","level":2,"score":0.44201192259788513},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.423162579536438},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42248091101646423},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4179248809814453},{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.41197165846824646},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.32118135690689087},{"id":"https://openalex.org/C95121573","wikidata":"https://www.wikidata.org/wiki/Q190474","display_name":"Activation energy","level":2,"score":0.21470043063163757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07939502596855164},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003890","descriptor_name":"Desiccation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006813","descriptor_name":"Humidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2014.11.063","doi":"https://doi.org/10.1016/j.ijpharm.2014.11.063","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2014.11.063","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:25450477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25450477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W135706948","https://openalex.org/W978294694","https://openalex.org/W1563591576","https://openalex.org/W1590254871","https://openalex.org/W1970767638","https://openalex.org/W1978298690","https://openalex.org/W1978360146","https://openalex.org/W1983483344","https://openalex.org/W1995759327","https://openalex.org/W1996785333","https://openalex.org/W1998647396","https://openalex.org/W1999977692","https://openalex.org/W2005816736","https://openalex.org/W2009413151","https://openalex.org/W2009938495","https://openalex.org/W2011947404","https://openalex.org/W2013155776","https://openalex.org/W2014879978","https://openalex.org/W2015433865","https://openalex.org/W2015633580","https://openalex.org/W2029846748","https://openalex.org/W2040432233","https://openalex.org/W2041517295","https://openalex.org/W2042481067","https://openalex.org/W2046027112","https://openalex.org/W2046571273","https://openalex.org/W2056434768","https://openalex.org/W2056853058","https://openalex.org/W2056995570","https://openalex.org/W2060137844","https://openalex.org/W2062593306","https://openalex.org/W2066935923","https://openalex.org/W2070701021","https://openalex.org/W2073776376","https://openalex.org/W2075179133","https://openalex.org/W2081217644","https://openalex.org/W2082203116","https://openalex.org/W2087659180","https://openalex.org/W2089828431","https://openalex.org/W2094040430","https://openalex.org/W2105448626","https://openalex.org/W2114263081","https://openalex.org/W2126209235","https://openalex.org/W2129240970","https://openalex.org/W2151915406","https://openalex.org/W2169796533","https://openalex.org/W2482385581","https://openalex.org/W3085471114","https://openalex.org/W6625652046","https://openalex.org/W6783760694"],"related_works":["https://openalex.org/W2809432332","https://openalex.org/W2765586046","https://openalex.org/W2046613127","https://openalex.org/W3094743917","https://openalex.org/W3217515078","https://openalex.org/W2024610484","https://openalex.org/W3194210640","https://openalex.org/W4394693271","https://openalex.org/W2776208400","https://openalex.org/W2265223650"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
