{"id":"https://openalex.org/W2000258624","doi":"https://doi.org/10.1016/0960-894x(96)00216-8","title":"Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-\u03b2-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds","display_name":"Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-\u03b2-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2000258624","doi":"https://doi.org/10.1016/0960-894x(96)00216-8","mag":"2000258624"},"language":"en","primary_location":{"id":"doi:10.1016/0960-894x(96)00216-8","doi":"https://doi.org/10.1016/0960-894x(96)00216-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0960-894x(96)00216-8","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043145057","display_name":"Stefano Manfredini","orcid":"https://orcid.org/0000-0003-1348-4422","observed_orcids":["https://orcid.org/0000-0003-1348-4422"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Stefano Manfredini","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","I-44100 Ferrara, Italy. Fax: +39.532.29.1296"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067835611","display_name":"Rita Bazzanini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rita Bazzanini","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","I-44100 Ferrara, Italy. Fax: +39.532.29.1296"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063804577","display_name":"Pier Giovanni Baraldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pier Giovanni Baraldi","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","I-44100 Ferrara, Italy. Fax: +39.532.29.1296"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101540856","display_name":"Daniele Simoni","orcid":"https://orcid.org/0000-0002-1701-9045","observed_orcids":["https://orcid.org/0000-0002-1701-9045"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Simoni","raw_affiliation_strings":["Istituto Farmacochimico, Universit\u00e0 di Palermo Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Farmacochimico, Universit\u00e0 di Palermo Cagliari. Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034828655","display_name":"Silvia Vertuani","orcid":"https://orcid.org/0000-0002-3228-0997","observed_orcids":["https://orcid.org/0000-0002-3228-0997"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvia Vertuani","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","I-44100 Ferrara, Italy. Fax: +39.532.29.1296"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19; I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Ferrara, Via Fossato di Mortara 17-19","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"I-44100 Ferrara, Italy. Fax: +39.532.29.1296","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078275872","display_name":"Alessandra Pani","orcid":"https://orcid.org/0000-0002-0437-2499","observed_orcids":["https://orcid.org/0000-0002-0437-2499"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Pani","raw_affiliation_strings":["Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066250100","display_name":"Elisabetta Pinna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabetta Pinna","raw_affiliation_strings":["Sardinian Antiviral Research Consortium, Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sardinian Antiviral Research Consortium, Cagliari. Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111765670","display_name":"Franca Scintu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franca Scintu","raw_affiliation_strings":["Sardinian Antiviral Research Consortium, Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sardinian Antiviral Research Consortium, Cagliari. Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079939487","display_name":"D. Lichino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Lichino","raw_affiliation_strings":["Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103853150","display_name":"Paolo La Colla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo La Colla","raw_affiliation_strings":["Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy","Sardinian Antiviral Research Consortium, Cagliari. Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia Sperimentale, Universit\u00e0 di Cagliari, Cagliari. Italy","institution_ids":["https://openalex.org/I172446870"]},{"raw_affiliation_string":"Sardinian Antiviral Research Consortium, Cagliari. Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034828655","https://openalex.org/A5043145057","https://openalex.org/A5063804577","https://openalex.org/A5067835611"],"corresponding_institution_ids":["https://openalex.org/I201324441"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.2997,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.51247258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"11","first_page":"1279","last_page":"1284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazole-nucleosides","display_name":"pyrazole nucleosides","score":0.8849999904632568},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8489999771118164},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.875},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9471337795257568},{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.9254937767982483},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7482166290283203},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.7197557687759399},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6883859634399414},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.6165452003479004},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.606752872467041},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5604199171066284},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4971154034137726},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4795626997947693},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4447604715824127},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.4147678315639496},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3459828495979309},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1986665427684784},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17637455463409424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11726051568984985},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0875069797039032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/0960-894x(96)00216-8","doi":"https://doi.org/10.1016/0960-894x(96)00216-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0960-894x(96)00216-8","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmh:oai:iris.unica.it:11584/9982","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/9982","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sfera.unife.it:11392/1197555","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/1197555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W943078686","https://openalex.org/W1748001607","https://openalex.org/W1966668708","https://openalex.org/W1969206572","https://openalex.org/W1982301628","https://openalex.org/W1986647481","https://openalex.org/W2004487345","https://openalex.org/W2004589611","https://openalex.org/W2006332669","https://openalex.org/W2027797101","https://openalex.org/W2049684660","https://openalex.org/W2064104709","https://openalex.org/W2064516222","https://openalex.org/W2086801105","https://openalex.org/W2098554674","https://openalex.org/W2122767035"],"related_works":["https://openalex.org/W2794761550","https://openalex.org/W7024270657","https://openalex.org/W6996186552","https://openalex.org/W7042722079","https://openalex.org/W2128465882","https://openalex.org/W2949727380","https://openalex.org/W2004589611","https://openalex.org/W2047694975","https://openalex.org/W2007527793","https://openalex.org/W2415342466"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}