{"id":"https://openalex.org/W2000254706","doi":"https://doi.org/10.1182/blood-2008-07-167759","title":"The hematopoiesis paradigm: clarity or ambiguity?","display_name":"The hematopoiesis paradigm: clarity or ambiguity?","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W2000254706","doi":"https://doi.org/10.1182/blood-2008-07-167759","mag":"2000254706","pmid":"https://pubmed.ncbi.nlm.nih.gov/18948582"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2008-07-167759","doi":"https://doi.org/10.1182/blood-2008-07-167759","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2008-07-167759","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058892166","display_name":"Chozhavendan Rathinam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chozhavendan Rathinam","raw_affiliation_strings":["YALE UNIVERSITY SCHOOL OF MEDICINE","Yale University School of Medicine >  >  >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YALE UNIVERSITY SCHOOL OF MEDICINE","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine >  >  >  >","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064443404","display_name":"Richard Anthony Flavell","orcid":"https://orcid.org/0000-0003-4461-0778","observed_orcids":["https://orcid.org/0000-0003-4461-0778"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Flavell","raw_affiliation_strings":["YALE UNIVERSITY SCHOOL OF MEDICINE","Yale University School of Medicine >  >  >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YALE UNIVERSITY SCHOOL OF MEDICINE","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine >  >  >  >","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.5724,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69592756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"112","issue":"9","first_page":"3534","last_page":"3535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lineage-differentiation","display_name":"lineage differentiation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lineage-plasticity","display_name":"lineage plasticity","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hematopoietic-lineage-specification","display_name":"hematopoietic lineage specification","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.9259060025215149},{"id":"https://openalex.org/C2777146004","wikidata":"https://www.wikidata.org/wiki/Q14949826","display_name":"CLARITY","level":2,"score":0.634820818901062},{"id":"https://openalex.org/C2780522230","wikidata":"https://www.wikidata.org/wiki/Q1140419","display_name":"Ambiguity","level":2,"score":0.5949174165725708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5436453819274902},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5398662686347961},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.45226070284843445},{"id":"https://openalex.org/C2777620950","wikidata":"https://www.wikidata.org/wiki/Q189105","display_name":"Cell lineage","level":4,"score":0.4420335590839386},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4272429347038269},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.27754029631614685},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2704102396965027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26907065510749817},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12235701084136963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10346987843513489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2008-07-167759","doi":"https://doi.org/10.1182/blood-2008-07-167759","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2008-07-167759","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:18948582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18948582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Comment"},{"id":"pmh:oai:pubmedcentral.nih.gov:2572785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572785","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2572785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2572785","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1585647397","https://openalex.org/W1827636252","https://openalex.org/W1992439632","https://openalex.org/W2042806609","https://openalex.org/W2087143957","https://openalex.org/W2093987146","https://openalex.org/W2101151637","https://openalex.org/W2102085111","https://openalex.org/W4313343467"],"related_works":["https://openalex.org/W2042826257","https://openalex.org/W1584790000","https://openalex.org/W2051373661","https://openalex.org/W2066343735","https://openalex.org/W4241815234","https://openalex.org/W3144192360","https://openalex.org/W2091013032","https://openalex.org/W4388366256","https://openalex.org/W2610470949","https://openalex.org/W2255723888"],"abstract_inverted_index":{"For":[0],"several":[1],"years,":[2],"the":[3,23,47],"lineage":[4,48],"differentiation":[5,49],"program":[6],"of":[7,25,43],"HSCs":[8],"was":[9],"believed":[10],"to":[11,28],"be":[12,52],"well":[13],"organized":[14],"and":[15,37],"unidirectional.":[16],"However,":[17],"data":[18],"from":[19],"recent":[20],"studies":[21],"question":[22],"commitment":[24],"lineage-restricted":[26],"progenitors":[27],"a":[29],"single":[30],"lineage.":[31],"Now,":[32],"interesting":[33],"work":[34],"by":[35],"Welner":[36],"colleagues":[38],"presented":[39],"in":[40],"this":[41],"issue":[42],"Blood":[44],"suggests":[45],"that":[46],"pathways":[50],"may":[51],"more":[53],"complicated":[54],"than":[55],"initially":[56],"thought.":[57]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}