{"id":"https://openalex.org/W2000253001","doi":"https://doi.org/10.1021/bi00098a017","title":"Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B","display_name":"Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B","publication_year":1991,"publication_date":"1991-08-27","ids":{"openalex":"https://openalex.org/W2000253001","doi":"https://doi.org/10.1021/bi00098a017","mag":"2000253001","pmid":"https://pubmed.ncbi.nlm.nih.gov/1883825"},"language":"en","primary_location":{"id":"doi:10.1021/bi00098a017","doi":"https://doi.org/10.1021/bi00098a017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00098a017","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020199932","display_name":"James S. Vincent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Vincent","raw_affiliation_strings":["Chemistry Department, University of Maryland Baltimore County, Catonsville 21228"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, University of Maryland Baltimore County, Catonsville 21228","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019286494","display_name":"Susan D. Revak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan D. Revak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111823341","display_name":"Charles G. Cochrane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles G. Cochrane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111569185","display_name":"Ira W. Levin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ira W. Levin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.3214,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.79499674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"30","issue":"34","first_page":"8395","last_page":"8401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dipalmitoylphosphatidylcholine","display_name":"DPPC","score":0.906000018119812},{"id":"https://openalex.org/keywords/phosphatidylglycerol","display_name":"phosphatidylglycerol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-peptide-interactions","display_name":"peptide-lipid interactions","score":0.7360000014305115},{"id":"https://openalex.org/keywords/multilamellar-vesicles","display_name":"multilamellar vesicles","score":0.6389999985694885},{"id":"https://openalex.org/keywords/gel-to-liquid-crystalline-phase-transition","display_name":"gel to liquid-crystalline phase transition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/phase-transition-temperature","display_name":"phase transition temperature","score":0.5189999938011169},{"id":"https://openalex.org/keywords/surface-tension-reduction","display_name":"surface tension reduction","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lipid-reorganization","display_name":"lipid reorganization","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2781172473","wikidata":"https://www.wikidata.org/wiki/Q2587934","display_name":"Dipalmitoylphosphatidylcholine","level":5,"score":0.9320918321609497},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.7626152038574219},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7389153242111206},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.7338411211967468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6982142925262451},{"id":"https://openalex.org/C2780726299","wikidata":"https://www.wikidata.org/wiki/Q3078751","display_name":"Phosphatidylglycerol","level":5,"score":0.6591549515724182},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.6357563734054565},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.6356715559959412},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6125439405441284},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5263620018959045},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4009387791156769},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.39291244745254517},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2888442575931549},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.173030823469162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1343839466571808},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.12020695209503174},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010715","descriptor_name":"Phosphatidylglycerols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011510","descriptor_name":"Proteolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015060","descriptor_name":"1,2-Dipalmitoylphosphatidylcholine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00098a017","doi":"https://doi.org/10.1021/bi00098a017","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00098a017","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:1883825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1883825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G327217574","display_name":"SCOR IN ACUTE LUNG INJURY","funder_award_id":"5p50hl023584-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5644749216","display_name":null,"funder_award_id":"HL-23584","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1547943040","https://openalex.org/W1917099971","https://openalex.org/W1988262622","https://openalex.org/W1994204296","https://openalex.org/W2004176673","https://openalex.org/W2007523733","https://openalex.org/W2012053092","https://openalex.org/W2016637718","https://openalex.org/W2057427073","https://openalex.org/W2067696247","https://openalex.org/W2071949957","https://openalex.org/W2080667505","https://openalex.org/W2081202307","https://openalex.org/W2082281596","https://openalex.org/W2084088944","https://openalex.org/W2084679669","https://openalex.org/W2085893671","https://openalex.org/W2088141654","https://openalex.org/W2131136771","https://openalex.org/W2320556745","https://openalex.org/W2411368629","https://openalex.org/W2462018642"],"related_works":["https://openalex.org/W2061711851","https://openalex.org/W2042389982","https://openalex.org/W2089852581","https://openalex.org/W2057582726","https://openalex.org/W1975891750","https://openalex.org/W1976763077","https://openalex.org/W4410303241","https://openalex.org/W1971922832","https://openalex.org/W2007705495","https://openalex.org/W2082960898"],"abstract_inverted_index":{"The":[0,24],"temperature":[1],"dependence":[2],"of":[3,29,32,47,70,72,132,144,194],"dipalmitoylphosphatidylcholine":[4],"(DPPC)/phosphatidylglycerol":[5],"(PG)":[6],"multilayers,":[7],"reconstituted":[8,109,150],"with":[9],"various":[10,116],"synthetic":[11,25],"peptides":[12,26,43],"for":[13,103,120,187,198],"modeling":[14],"human":[15,34],"lung":[16],"surfactant,":[17],"was":[18],"monitored":[19],"by":[20,50,160],"vibrational":[21],"Raman":[22,79,81,117],"spectroscopy.":[23],"consisted,":[27],"respectively,":[28],"residues":[30],"59-81":[31],"the":[33,62,67,73,78,108,115,121,141,148,154,174,188,192,199],"surfactant":[35,152],"protein":[36],"SP-B":[37],"and":[38,86,211],"21":[39],"amino":[40],"acid":[41],"residue":[42],"containing":[44],"repeating":[45],"units":[46],"arginine":[48],"separated":[49],"either":[51],"four":[52],"or":[53,57],"eight":[54],"leucines":[55],"(RL4":[56],"RL8).":[58],"Each":[59],"peptide":[60,175],"demonstrated":[61],"ability":[63],"to":[64,96,140,178],"reduce":[65],"significantly":[66,208],"surface":[68],"tension":[69],"analogues":[71],"phospholipid":[74],"mixture":[75],"used":[76,95],"in":[77,107,173],"studies.":[80],"spectroscopic":[82],"integrated":[83],"band":[84],"intensities":[85],"relative":[87],"peak":[88],"height":[89],"intensity":[90,118],"ratios,":[91],"two":[92],"spectral":[93,129],"parameters":[94,119],"determine":[97],"bilayer":[98,142],"disorder,":[99],"provided":[100],"sensitive":[101],"probes":[102],"characterizing":[104],"multilayer":[105],"perturbations":[106],"liposomes.":[110,190],"Temperature":[111],"profiles":[112],"derived":[113,214],"from":[114,169],"3100-2800-cm-1":[122],"carbon-hydrogen":[123],"(C-H)":[124],"stretching":[125,164],"mode":[126,165],"region,":[127],"a":[128],"interval":[130],"representative":[131],"acyl":[133,161],"chain":[134,162],"vibrations,":[135],"reflected":[136],"lipid":[137,184],"reorganizations":[138],"due":[139],"interactions":[143],"these":[145],"peptides.":[146],"For":[147],"three":[149,200],"multilamellar":[151],"systems,":[153],"gel-to-liquid-crystalline":[155],"phase-transition":[156,205],"temperatures":[157],"Tm,":[158],"defined":[159],"C-H":[163],"order/disorder":[166,215],"parameters,":[167],"increased":[168,183],"35":[170],"degrees":[171,180],"C":[172],"free":[176],"system":[177],"37-38":[179],"C,":[181],"indicating":[182],"headgroup":[185],"constraints":[186],"model":[189],"Although":[191],"values":[193],"Tm":[195],"were":[196],"similar":[197],"recombinant":[201],"lipid/peptide":[202],"assemblies,":[203],"individual":[204],"cooperativities":[206],"varied":[207],"between":[209,212],"systems":[210],"spectroscopically":[213],"parameters.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}