{"id":"https://openalex.org/W2000251927","doi":"https://doi.org/10.1523/jneurosci.4101-08.2008","title":"Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their StabilityIn Vivo","display_name":"Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their StabilityIn Vivo","publication_year":2008,"publication_date":"2008-11-26","ids":{"openalex":"https://openalex.org/W2000251927","doi":"https://doi.org/10.1523/jneurosci.4101-08.2008","mag":"2000251927","pmid":"https://pubmed.ncbi.nlm.nih.gov/19036972","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2610528"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4101-08.2008","doi":"https://doi.org/10.1523/jneurosci.4101-08.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4101-08.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/48/12798.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/28/48/12798.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011526572","display_name":"Emmanuel Planel","orcid":"https://orcid.org/0000-0001-5128-0565","observed_orcids":["https://orcid.org/0000-0001-5128-0565"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Planel","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011483217","display_name":"Pavan Krishnamurthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavan Krishnamurthy","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037301114","display_name":"Tomohiro Miyasaka","orcid":"https://orcid.org/0000-0003-4867-7910","observed_orcids":["https://orcid.org/0000-0003-4867-7910"]},"institutions":[{"id":"https://openalex.org/I133984924","display_name":"Doshisha University","ror":"https://ror.org/01fxdkm29","country_code":"JP","type":"education","lineage":["https://openalex.org/I133984924"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Miyasaka","raw_affiliation_strings":["Faculty of Life and Medical Sciences, Department of Medical Life Systems, Doshisha University, Kyoto 610-0394, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life and Medical Sciences, Department of Medical Life Systems, Doshisha University, Kyoto 610-0394, Japan,","institution_ids":["https://openalex.org/I133984924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418899","display_name":"Li Liu","orcid":"https://orcid.org/0000-0003-2314-8756","observed_orcids":["https://orcid.org/0000-0003-2314-8756"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050067880","display_name":"Mathieu Herman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathieu Herman","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103599378","display_name":"Asok R. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asok Kumar","raw_affiliation_strings":["Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962,","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087615255","display_name":"Alexis Bretteville","orcid":"https://orcid.org/0000-0003-2426-0627","observed_orcids":["https://orcid.org/0000-0003-2426-0627"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Bretteville","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064009490","display_name":"Helen Y. Figueroa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Y. Figueroa","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024970198","display_name":"Wai Haung Yu","orcid":"https://orcid.org/0000-0001-7186-6731","observed_orcids":["https://orcid.org/0000-0001-7186-6731"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wai Haung Yu","raw_affiliation_strings":["Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taub Institute for Alzheimer's Disease Research, Department of Pathology, Columbia University Medical Center, New York, New York 10032,","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111802907","display_name":"Robert A. Whittington","orcid":"https://orcid.org/0000-0001-7877-1209","observed_orcids":["https://orcid.org/0000-0001-7877-1209"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Whittington","raw_affiliation_strings":["Department of Anesthesiology, Columbia University, New York, New York 10027,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Columbia University, New York, New York 10027,","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047196957","display_name":"Peter Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Davies","raw_affiliation_strings":["Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, and","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103213652","display_name":"Akihiko Takashima","orcid":"https://orcid.org/0000-0001-7795-9859","observed_orcids":["https://orcid.org/0000-0001-7795-9859"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Takashima","raw_affiliation_strings":["The Institute of Physical and Chemical Research (RIKEN), Brain Science Institute, Laboratory for Alzheimer's Disease, Wako-shi, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Physical and Chemical Research (RIKEN), Brain Science Institute, Laboratory for Alzheimer's Disease, Wako-shi, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022090615","display_name":"Ralph A. Nixon","orcid":"https://orcid.org/0000-0001-5124-1021","observed_orcids":["https://orcid.org/0000-0001-5124-1021"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Nixon","raw_affiliation_strings":["Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962,","Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962,","institution_ids":["https://openalex.org/I125043107"]},{"raw_affiliation_string":"Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006563536","display_name":"Karen Duff","orcid":"https://orcid.org/0000-0002-6177-868X","observed_orcids":["https://orcid.org/0000-0002-6177-868X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen E. Duff","raw_affiliation_strings":["Columbia University Medical Center, Taub Institute for Alzheimer\u2019s Disease Research, Department of Pathology, New York, New York, United States of America","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Medical Center, Taub Institute for Alzheimer\u2019s Disease Research, Department of Pathology, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8748,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.82940291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"28","issue":"48","first_page":"12798","last_page":"12807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/microtubule-binding","display_name":"microtubule binding","score":0.746999979019165},{"id":"https://openalex.org/keywords/microtubule-stability","display_name":"microtubule stability","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anesthesia-induced-hypothermia","display_name":"anesthesia-induced hypothermia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tubulin-depolymerization","display_name":"tubulin depolymerization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.7823178768157959},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7724528908729553},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7131997346878052},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5489651560783386},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.524167537689209},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5169429183006287},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4838256239891052},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.48073577880859375},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.4802315831184387},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4642043709754944},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44295555353164673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41361546516418457},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.344571590423584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33490294218063354},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.23318058252334595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20624864101409912},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.20124080777168274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16072627902030945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14324936270713806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11508333683013916},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10258746147155762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06988951563835144}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018911","descriptor_name":"Trinucleotide Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.4101-08.2008","doi":"https://doi.org/10.1523/jneurosci.4101-08.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4101-08.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/48/12798.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2610528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2610528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:19036972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19036972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1454480","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2610528","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4101-08.2008","doi":"https://doi.org/10.1523/jneurosci.4101-08.2008","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4101-08.2008","pdf_url":"https://www.jneurosci.org/content/jneuro/28/48/12798.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4368771867","display_name":"Pathological and Functional Impact of Tauopathy in vivo","funder_award_id":"P01NS048447","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G723260309","display_name":"A Mouse Model of Tau Pathology in AD and Other Dementias","funder_award_id":"R01AG022102","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7425391916","display_name":"Tau and Neurodegeneration II: A therapeutic target","funder_award_id":"P01AG017216","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000251927.pdf","grobid_xml":"https://content.openalex.org/works/W2000251927.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W157501186","https://openalex.org/W189289305","https://openalex.org/W1509571186","https://openalex.org/W1528790659","https://openalex.org/W1557116095","https://openalex.org/W1600934558","https://openalex.org/W1606423922","https://openalex.org/W1674770932","https://openalex.org/W1852059769","https://openalex.org/W1962351296","https://openalex.org/W1963791487","https://openalex.org/W1966899328","https://openalex.org/W1966959566","https://openalex.org/W1969965994","https://openalex.org/W1971775491","https://openalex.org/W1973774127","https://openalex.org/W1976576149","https://openalex.org/W1977879318","https://openalex.org/W1982487434","https://openalex.org/W1984482388","https://openalex.org/W1984770038","https://openalex.org/W1987012898","https://openalex.org/W2002347888","https://openalex.org/W2005199015","https://openalex.org/W2007472518","https://openalex.org/W2008675281","https://openalex.org/W2014636427","https://openalex.org/W2021312655","https://openalex.org/W2021590064","https://openalex.org/W2023227738","https://openalex.org/W2023378497","https://openalex.org/W2027331854","https://openalex.org/W2035318781","https://openalex.org/W2036008741","https://openalex.org/W2039468514","https://openalex.org/W2042891876","https://openalex.org/W2046948369","https://openalex.org/W2049992970","https://openalex.org/W2053063666","https://openalex.org/W2053695273","https://openalex.org/W2054619408","https://openalex.org/W2055433327","https://openalex.org/W2056470407","https://openalex.org/W2057013121","https://openalex.org/W2057058939","https://openalex.org/W2058570072","https://openalex.org/W2059930117","https://openalex.org/W2061655823","https://openalex.org/W2062772621","https://openalex.org/W2065214273","https://openalex.org/W2065392160","https://openalex.org/W2066232800","https://openalex.org/W2071397750","https://openalex.org/W2077859404","https://openalex.org/W2079783388","https://openalex.org/W2085515436","https://openalex.org/W2088073407","https://openalex.org/W2091014617","https://openalex.org/W2098101838","https://openalex.org/W2106218338","https://openalex.org/W2108177092","https://openalex.org/W2110193116","https://openalex.org/W2111040212","https://openalex.org/W2126024001","https://openalex.org/W2126124658","https://openalex.org/W2126279450","https://openalex.org/W2127229268","https://openalex.org/W2130723719","https://openalex.org/W2143050153","https://openalex.org/W2148570557","https://openalex.org/W2155125470","https://openalex.org/W2157319245","https://openalex.org/W2159994020","https://openalex.org/W2164136371","https://openalex.org/W2169217121","https://openalex.org/W2172141724","https://openalex.org/W2182661714","https://openalex.org/W2337702294","https://openalex.org/W6656364213","https://openalex.org/W7118126936"],"related_works":["https://openalex.org/W1969979382","https://openalex.org/W2050346818","https://openalex.org/W2915622491","https://openalex.org/W2071442046","https://openalex.org/W2085782370","https://openalex.org/W1985053970","https://openalex.org/W2149265519","https://openalex.org/W2151397539","https://openalex.org/W2038298761","https://openalex.org/W2042171021"],"abstract_inverted_index":{"In":[0],"Alzheimer's":[1],"disease,":[2],"tau":[3,33,47,62,71,73,84,95,126],"is":[4,7,148],"hyperphosphorylated,":[5,49],"which":[6,50],"thought":[8],"to":[9,54,66,101,128,150],"detach":[10],"it":[11],"from":[12,77,86,96],"microtubules":[13],"(MTs),":[14],"induce":[15],"MT":[16,59,87,115,152],"destabilization,":[17],"and":[18,37,57,72,106],"promote":[19,58],"aggregation.":[20],"Using":[21],"a":[22,123],"previously":[23],"described":[24],"in":[25,35,79,88,121],"vivo":[26],"model,":[27],"we":[28],"investigated":[29],"whether":[30],"hyperphosphorylation":[31,67],"impacts":[32],"function":[34],"wild-type":[36,80],"transgenic":[38,90],"mice.":[39,81,91],"We":[40],"found":[41],"that":[42,136],"after":[43],"anesthesia-induced":[44],"hypothermia,":[45],"MT-free":[46],"was":[48,63,108],"impaired":[51],"its":[52],"ability":[53],"bind":[55],"MTs":[56,78,97,129,144],"assembly.":[60],"MT-bound":[61],"more":[64],"resistant":[65],"compared":[68],"with":[69],"free":[70],"did":[74,98],"not":[75,99,131],"dissociate":[76,133],"However,":[82],"3-repeat":[83],"detached":[85],"the":[89,143],"Surprisingly,":[92],"dissociation":[93],"of":[94,104,113,125],"lead":[100],"overt":[102],"depolymerization":[103],"tubulin,":[105],"there":[107],"no":[109],"collapse,":[110],"or":[111],"disturbance":[112],"axonal":[114],"networks.":[116],"These":[117],"results":[118],"indicate":[119],"that,":[120],"vivo,":[122],"subpopulation":[124],"bound":[127],"does":[130],"easily":[132],"under":[134,145],"conditions":[135,147],"extensively":[137],"phosphorylate":[138],"tau.":[139],"Tau":[140],"remaining":[141],"on":[142],"these":[146],"sufficient":[149],"maintain":[151],"network":[153],"integrity.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
