{"id":"https://openalex.org/W2000250623","doi":"https://doi.org/10.1002/jbt.2570060306","title":"Role of cytochrome P\u2010450 in ochratoxin a\u2010stimulated lipid peroxidation","display_name":"Role of cytochrome P\u2010450 in ochratoxin a\u2010stimulated lipid peroxidation","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2000250623","doi":"https://doi.org/10.1002/jbt.2570060306","mag":"2000250623","pmid":"https://pubmed.ncbi.nlm.nih.gov/1770504"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.2570060306","doi":"https://doi.org/10.1002/jbt.2570060306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.2570060306","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000250623"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028575696","display_name":"Rabeea F. Omar","orcid":"https://orcid.org/0000-0002-8083-8748","observed_orcids":["https://orcid.org/0000-0002-8083-8748"]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rabeea F. Omar","raw_affiliation_strings":["Department of Biochemistry, Memorial University, St. John's, Newfoundland, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180066","display_name":"Anver D. Rahimtula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Anver D. Rahimtula","raw_affiliation_strings":["Department of Biochemistry, Memorial University, St. John's, Newfoundland, Canada A1B 3X9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Memorial University, St. John's, Newfoundland, Canada A1B 3X9","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052781070","display_name":"Helmut Bartsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Helmut Bartsch","raw_affiliation_strings":["Unit of Environmental Carcinogens and Host Factors, International Agency for Research on Cancer, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Environmental Carcinogens and Host Factors, International Agency for Research on Cancer, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110180066"],"corresponding_institution_ids":["https://openalex.org/I130438778"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.9871,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.74621405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"3","first_page":"203","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ochratoxin-a","display_name":"ochratoxin A","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cobalt-protoporphyrin","display_name":"cobalt protoporphyrin","score":0.953000009059906},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.9023181200027466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7012291550636292},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6394773125648499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6113203167915344},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.518999457359314},{"id":"https://openalex.org/C2776008721","wikidata":"https://www.wikidata.org/wiki/Q1885038","display_name":"Ochratoxin A","level":3,"score":0.4984879493713379},{"id":"https://openalex.org/C2778417259","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin","level":3,"score":0.4154571294784546},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.24891340732574463},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.2094087302684784},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1234002411365509},{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.12079823017120361},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11755362153053284},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11289399862289429}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009793","descriptor_name":"Ochratoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.2570060306","doi":"https://doi.org/10.1002/jbt.2570060306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.2570060306","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical Toxicology","raw_type":"journal-article"},{"id":"pmid:1770504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1770504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319947","display_name":"Kidney Foundation of Canada","ror":"https://ror.org/019a0gk53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W20905607","https://openalex.org/W273978429","https://openalex.org/W1532212858","https://openalex.org/W1585585503","https://openalex.org/W1775749144","https://openalex.org/W2014616684","https://openalex.org/W2028394231","https://openalex.org/W2032336668","https://openalex.org/W2038381447","https://openalex.org/W2058187173","https://openalex.org/W2064500198","https://openalex.org/W2064552928","https://openalex.org/W2078233940","https://openalex.org/W2082741751","https://openalex.org/W2086868880","https://openalex.org/W2087434970","https://openalex.org/W2129426399","https://openalex.org/W2143940359","https://openalex.org/W2152311269","https://openalex.org/W2315703596","https://openalex.org/W2490797021","https://openalex.org/W2592156898"],"related_works":["https://openalex.org/W2058187173","https://openalex.org/W2007262004","https://openalex.org/W1976652926","https://openalex.org/W2078933097","https://openalex.org/W2032336668","https://openalex.org/W2093130967","https://openalex.org/W2121665268","https://openalex.org/W2070974144","https://openalex.org/W4304891866","https://openalex.org/W2129381630"],"abstract_inverted_index":{"The":[0],"role":[1,105,175,192],"of":[2,8,35,74,91,106,123,141,146,176],"cytochrome":[3,57,93,108,177],"P-450":[4,39,94,109,178],"in":[5,30,63,95,110,147,158,163,179,184,193,196],"the":[6,12,72,104,139,173],"stimulation":[7],"lipid":[9,28,65,130,149,182,200],"peroxidation":[10,29,66,131,183],"by":[11],"nephrotoxic":[13],"mycotoxin":[14],"ochratoxin":[15,128,152,180,198],"A":[16,21,153],"has":[17,99],"been":[18,100],"investigated.":[19],"Ochratoxin":[20],"was":[22,155],"previously":[23],"shown":[24],"to":[25,78,84,102],"markedly":[26],"stimulate":[27],"a":[31,185],"reconstituted":[32,186],"system":[33,187],"consisting":[34],"phospholipid":[36],"vesicles,":[37],"NADPH-cytochrome":[38],"reductase,":[40],"Fe3+,":[41],"ethylenediaminetetraacetic":[42],"acid":[43],"(EDTA),":[44],"and":[45,88,97,113,188,195],"reduced":[46],"nicotinamide":[47],"adenine":[48],"dinucleotide":[49],"phosphate":[50],"(NADPH).":[51],"We":[52,115],"now":[53],"show":[54],"that":[55,68,118],"purified":[56],"P-450IIB1":[58],"could":[59,70],"effectively":[60],"replace":[61],"EDTA":[62],"stimulating":[64],"suggesting":[67],"it":[69,98],"mediate":[71],"transfer":[73],"electrons":[75],"from":[76,121],"NADPH":[77],"Fe3+.":[79],"Cobalt":[80],"protoporphyrin":[81],"is":[82],"known":[83],"cause":[85],"an":[86],"extensive":[87],"long-lasting":[89],"depletion":[90],"hepatic":[92,107],"rats,":[96],"used":[101],"evaluate":[103],"xenobiotic":[111],"metabolism":[112],"toxicity.":[114],"have":[116],"observed":[117],"microsomes":[119],"isolated":[120],"livers":[122],"cobalt":[124,159],"protoporphyrin-pretreated":[125,160],"rats":[126,161],"underwent":[127],"A-dependent":[129],"much":[132,156],"more":[133],"slowly":[134],"than":[135,162],"control":[136,164],"microsomes.":[137],"Also,":[138],"level":[140],"ethane":[142],"exhaled":[143],"(an":[144],"index":[145],"vivo":[148,197],"peroxidation)":[150],"on":[151],"administration":[154],"lower":[157],"rats.":[165],"Taken":[166],"together,":[167],"these":[168],"results":[169],"provide":[170],"evidence":[171],"for":[172],"stimulatory":[174],"A-induced":[181,199],"strongly":[189],"implicate":[190],"its":[191],"microsomal":[194],"peroxidation.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
