{"id":"https://openalex.org/W2000243516","doi":"https://doi.org/10.1002/jhet.5570110505","title":"Synthesis of unsymmetrical 2,4\u2010dialkylpyrazolo[1,5\u2010a]\u20101,3,5\u2010triazines","display_name":"Synthesis of unsymmetrical 2,4\u2010dialkylpyrazolo[1,5\u2010a]\u20101,3,5\u2010triazines","publication_year":1974,"publication_date":"1974-10-01","ids":{"openalex":"https://openalex.org/W2000243516","doi":"https://doi.org/10.1002/jhet.5570110505","mag":"2000243516"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.5570110505","doi":"https://doi.org/10.1002/jhet.5570110505","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570110505","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034916787","display_name":"Thomas Novinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Novinson","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045284444","display_name":"KEITARO SENGA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keitaro Senga","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111792021","display_name":"J. Kobe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u017ee Kobe","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109087511","display_name":"Roland K. Robins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland K. Robins","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111708977","display_name":"Darrell E. O'Brien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrell E. O'Brien","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002474609","display_name":"Anthony A. Albert","orcid":"https://orcid.org/0000-0002-4445-5790","observed_orcids":["https://orcid.org/0000-0002-4445-5790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony A. Albert","raw_affiliation_strings":["ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICN Pharmaceuticals, Inc., Nucleic Acid Research Insitute, 2727 Campus Drive, Irvine, California 92664","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034916787"],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":2.6615,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86317635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"5","first_page":"691","last_page":"695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazolo-1-5-a-1-3-5-triazines","display_name":"pyrazolo[1,5-a][1,3,5]triazines","score":0.9670000076293945},{"id":"https://openalex.org/keywords/3-aminopyrazoles","display_name":"3-aminopyrazoles","score":0.9710000157356262},{"id":"https://openalex.org/keywords/imidate-esters","display_name":"imidate esters","score":0.9399999976158142},{"id":"https://openalex.org/keywords/orthoesters","display_name":"orthoesters","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/fused-triazines","display_name":"fused triazines","score":0.5370000004768372},{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9664517641067505},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.6842489838600159},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5684214234352112},{"id":"https://openalex.org/C2776303721","wikidata":"https://www.wikidata.org/wiki/Q419563","display_name":"Triazine","level":2,"score":0.505692720413208},{"id":"https://openalex.org/C146834321","wikidata":"https://www.wikidata.org/wiki/Q2979672","display_name":"Closure (psychology)","level":2,"score":0.48805463314056396},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3663191795349121},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.339324414730072},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jhet.5570110505","doi":"https://doi.org/10.1002/jhet.5570110505","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570110505","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1973450224","https://openalex.org/W1981848004","https://openalex.org/W2022111396","https://openalex.org/W2033745893","https://openalex.org/W2074133414","https://openalex.org/W2326763779","https://openalex.org/W4230205132"],"related_works":["https://openalex.org/W4242286962","https://openalex.org/W2026924520","https://openalex.org/W1990912602","https://openalex.org/W2019582392","https://openalex.org/W7154667014","https://openalex.org/W1969530407","https://openalex.org/W2950743742","https://openalex.org/W2039467159","https://openalex.org/W2904329659","https://openalex.org/W2085735736"],"abstract_inverted_index":{"Abstract":[0],"The":[1,38,48],"reaction":[2],"of":[3,22,40,51,59,68],"3\u2010aminopyrazole":[4],"with":[5,24],"imidate":[6],"esters":[7],"such":[8,26,34],"as":[9,27,35],"ethyl":[10,28],"acetimidate,":[11],"gave":[12],"N\u2010(pyrazol\u20103\u2010yl)acetamidine":[13],"(1)":[14],"rather":[15,76],"than":[16,77],"the":[17,57,78],"isomeric":[18],"2\u2010acetamidoyl\u20103\u2010aminopyrazole.":[19],"Ring":[20],"closure":[21],"1":[23,41],"orthoesters":[25],"propionimidate,":[29],"afforded":[30],"unsymmetrically":[31],"substituted":[32],"2.4\u2010dialkylpyrazolo[1,5\u2010a]\u20101,3,5\u2010triazines":[33],"4\u2010ethyl\u20102\u2010methylpyrazolo[1,5\u2010a]\u20101,3,5\u2010triazine":[36],"(3).":[37],"structure":[39],"was":[42],"confirmed":[43],"by":[44],"several":[45],"alternate":[46],"syntheses.":[47],"unique":[49],"feature":[50],"this":[52],"two\u2010step":[53],"synthetic":[54],"approach":[55],"to":[56],"synthesis":[58],"pyrazolo[1,5\u2010a]\u20101,3,5\u2010triazines":[60],"is":[61,64],"that":[62],"it":[63],"a":[65],"convenient":[66],"method":[67],"preparing":[69],"fused":[70],"triazines":[71],"based":[72],"on":[73],"available":[74],"pyrazoles":[75],"less":[79],"accessible":[80],"dialkyltriazines.":[81]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}