{"id":"https://openalex.org/W2000239178","doi":"https://doi.org/10.1002/pbc.23124","title":"Sirolimus for the treatment of complicated vascular anomalies in children","display_name":"Sirolimus for the treatment of complicated vascular anomalies in children","publication_year":2011,"publication_date":"2011-03-28","ids":{"openalex":"https://openalex.org/W2000239178","doi":"https://doi.org/10.1002/pbc.23124","mag":"2000239178","pmid":"https://pubmed.ncbi.nlm.nih.gov/21445948"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.23124","doi":"https://doi.org/10.1002/pbc.23124","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.23124","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.23124","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.23124","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086412697","display_name":"Adrienne M. Hammill","orcid":"https://orcid.org/0000-0003-0820-4924","observed_orcids":["https://orcid.org/0000-0003-0820-4924"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrienne M. Hammill","raw_affiliation_strings":["Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. adrienne.hammill@cchmc.org","Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. adrienne.hammill@cchmc.org","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002193069","display_name":"Mary Sue Wentzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MarySue Wentzel","raw_affiliation_strings":["Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anita Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Gupta","raw_affiliation_strings":["Division of Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055041074","display_name":"Stephen C. Nelson","orcid":"https://orcid.org/0000-0002-2019-4741","observed_orcids":["https://orcid.org/0000-0002-2019-4741"]},"institutions":[{"id":"https://openalex.org/I4210132437","display_name":"Children's Minnesota","ror":"https://ror.org/03d543283","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210132437"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Nelson","raw_affiliation_strings":["Pediatric Hematology-Oncology Program, Vascular Anomalies Center at Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology-Oncology Program, Vascular Anomalies Center at Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I4210132437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010901410","display_name":"Anne W. Lucky","orcid":"https://orcid.org/0000-0002-6115-7584","observed_orcids":["https://orcid.org/0000-0002-6115-7584"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Lucky","raw_affiliation_strings":["Division of Dermatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dermatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028166673","display_name":"Ravindhra G. Elluru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Elluru","raw_affiliation_strings":["Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Otolaryngology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030288227","display_name":"Roshni A. Dasgupta","orcid":"https://orcid.org/0000-0003-4839-4937","observed_orcids":["https://orcid.org/0000-0003-4839-4937"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roshni Dasgupta","raw_affiliation_strings":["Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073139387","display_name":"Richard G. Azizkhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Azizkhan","raw_affiliation_strings":["Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020599795","display_name":"Denise M. Adams","orcid":"https://orcid.org/0000-0002-2892-5369","observed_orcids":["https://orcid.org/0000-0002-2892-5369"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise M. Adams","raw_affiliation_strings":["Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Hemangioma and Vascular Malformation Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086412697"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":22.2619,"has_fulltext":false,"cited_by_count":622,"citation_normalized_percentile":{"value":0.99725986,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"57","issue":"6","first_page":"1018","last_page":"1024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/vascular-anomalies","display_name":"vascular anomalies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/kaposiform-hemangioendothelioma","display_name":"kaposiform hemangioendothelioma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/infantile-hemangioma","display_name":"infantile hemangioma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/vascular-malformations","display_name":"vascular malformations","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vascular-tumors","display_name":"vascular tumors","score":0.753000020980835},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7910000085830688},{"id":"https://openalex.org/keywords/expanded-access","display_name":"compassionate use","score":0.6179999709129333},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9302878975868225},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.8702872395515442},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.7741107940673828},{"id":"https://openalex.org/C2992972558","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Blood cancer","level":3,"score":0.5664563179016113},{"id":"https://openalex.org/C2908629526","wikidata":"https://www.wikidata.org/wiki/Q25422732","display_name":"Vascular Tumors","level":3,"score":0.4714530408382416},{"id":"https://openalex.org/C2775958455","wikidata":"https://www.wikidata.org/wiki/Q7916449","display_name":"Vascular anomaly","level":2,"score":0.4713817536830902},{"id":"https://openalex.org/C2777507709","wikidata":"https://www.wikidata.org/wiki/Q121576","display_name":"Vascular malformation","level":2,"score":0.4621027708053589},{"id":"https://openalex.org/C2780191036","wikidata":"https://www.wikidata.org/wiki/Q861028","display_name":"Hemangioma","level":2,"score":0.43945908546447754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33607733249664307},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3171069025993347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3128887116909027},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.24684810638427734},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D057176","descriptor_name":"Compassionate Use Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057176","descriptor_name":"Compassionate Use Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057176","descriptor_name":"Compassionate Use Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.23124","doi":"https://doi.org/10.1002/pbc.23124","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.23124","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.23124","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:21445948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21445948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pbc.23124","doi":"https://doi.org/10.1002/pbc.23124","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pbc.23124","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pbc.23124","source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000239178.pdf"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1011576099","https://openalex.org/W1499391718","https://openalex.org/W1969678653","https://openalex.org/W1969832654","https://openalex.org/W1970924960","https://openalex.org/W1971312231","https://openalex.org/W1971927882","https://openalex.org/W1991641569","https://openalex.org/W2001707369","https://openalex.org/W2006628947","https://openalex.org/W2021516618","https://openalex.org/W2044953204","https://openalex.org/W2047526031","https://openalex.org/W2049705652","https://openalex.org/W2050790870","https://openalex.org/W2050980183","https://openalex.org/W2052470905","https://openalex.org/W2057600556","https://openalex.org/W2057723733","https://openalex.org/W2059416910","https://openalex.org/W2062679525","https://openalex.org/W2063437420","https://openalex.org/W2071771837","https://openalex.org/W2076447370","https://openalex.org/W2085927367","https://openalex.org/W2089354038","https://openalex.org/W2097762430","https://openalex.org/W2102357022","https://openalex.org/W2108961893","https://openalex.org/W2113365503","https://openalex.org/W2124191809","https://openalex.org/W2144402307","https://openalex.org/W2155591311","https://openalex.org/W2157113519","https://openalex.org/W2169367027","https://openalex.org/W2316081222","https://openalex.org/W2331956906","https://openalex.org/W2415554417","https://openalex.org/W2415813565","https://openalex.org/W4234772264","https://openalex.org/W4247443744"],"related_works":["https://openalex.org/W34449777","https://openalex.org/W2951123792","https://openalex.org/W4229665481","https://openalex.org/W1998556125","https://openalex.org/W3004433832","https://openalex.org/W40395543","https://openalex.org/W4223937503","https://openalex.org/W2000239178","https://openalex.org/W3120819128","https://openalex.org/W3154235938"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vascular":[1,44],"anomalies":[2,75,121],"comprise":[3],"a":[4,66,139],"diverse":[5],"group":[6],"of":[7,16,29,68],"diagnoses.":[8],"While":[9],"infantile":[10],"hemangiomas":[11],"are":[12,19,133],"common,":[13],"the":[14,80],"majority":[15],"these":[17,30,129],"conditions":[18],"quite":[20],"rare":[21],"and":[22,51,114,122,143],"have":[23,55],"not":[24],"been":[25],"widely":[26],"studied.":[27],"Some":[28],"lesions,":[31],"though":[32],"benign,":[33],"can":[34],"impair":[35],"vital":[36],"structures,":[37],"be":[38,112],"deforming,":[39],"or":[40],"even":[41],"become":[42],"life-threatening.":[43],"tumors":[45],"such":[46],"as":[47],"kaposiform":[48],"hemangioendotheliomas":[49],"(KHE)":[50],"complicated":[52],"vascular":[53,74,120],"malformations":[54],"proven":[56],"particularly":[57],"difficult":[58],"to":[59,111],"treat.":[60],"PROCEDURE:":[61],"Here":[62],"we":[63],"retrospectively":[64],"evaluate":[65],"series":[67],"six":[69],"patients":[70,97,117],"with":[71,79,104,118],"complicated,":[72],"life-threatening":[73,119],"who":[76],"were":[77],"treated":[78],"mTOR":[81],"inhibitor":[82],"sirolimus":[83],"for":[84],"compassionate":[85],"use":[86],"at":[87],"two":[88],"centers":[89],"after":[90],"failing":[91],"multiple":[92],"other":[93],"therapies.":[94],"RESULTS:":[95],"These":[96,131],"showed":[98],"significant":[99],"improvement":[100],"in":[101,116,127,138],"clinical":[102],"status":[103],"tolerable":[105],"side":[106],"effects.":[107],"CONCLUSIONS:":[108],"Sirolimus":[109],"appears":[110],"effective":[113],"safe":[115],"represents":[123],"an":[124],"important":[125],"tool":[126],"treating":[128],"diseases.":[130],"findings":[132],"currently":[134],"being":[135],"further":[136],"evaluated":[137],"Phase":[140],"II":[141],"safety":[142],"efficacy":[144],"trial.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":60},{"year":2021,"cited_by_count":70},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":50},{"year":2018,"cited_by_count":39},{"year":2017,"cited_by_count":48},{"year":2016,"cited_by_count":52},{"year":2015,"cited_by_count":48},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
