{"id":"https://openalex.org/W2000239018","doi":"https://doi.org/10.3390/molecules17066996","title":"Xiao Han, et al., GHGKHKNK Octapeptide (P-5m) Inhibits Metastasis of HCCLM3 Cell Lines via Regulation of MMP-2 Expression in in Vitro and in Vivo Studies. Molecules, 2012, 17, 1357-1372","display_name":"Xiao Han, et al., GHGKHKNK Octapeptide (P-5m) Inhibits Metastasis of HCCLM3 Cell Lines via Regulation of MMP-2 Expression in in Vitro and in Vivo Studies. Molecules, 2012, 17, 1357-1372","publication_year":2012,"publication_date":"2012-06-06","ids":{"openalex":"https://openalex.org/W2000239018","doi":"https://doi.org/10.3390/molecules17066996","mag":"2000239018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6269009"},"language":"en","primary_location":{"id":"doi:10.3390/molecules17066996","doi":"https://doi.org/10.3390/molecules17066996","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules17066996","pdf_url":"https://www.mdpi.com/1420-3049/17/6/6996/pdf?version=1403113768","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/17/6/6996/pdf?version=1403113768","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110584353","display_name":"Xiao Han","orcid":"https://orcid.org/0000-0002-7059-6220","observed_orcids":["https://orcid.org/0000-0002-7059-6220"]},"institutions":[{"id":"https://openalex.org/I121691239","display_name":"Beihua University","ror":"https://ror.org/013jjp941","country_code":"CN","type":"education","lineage":["https://openalex.org/I121691239"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Han","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China","institution_ids":["https://openalex.org/I121691239"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong-Mei Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Mei Yan","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102437430","display_name":"Xiangfeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Feng Zhao","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058748014","display_name":"Hiroshi Matsuura","orcid":"https://orcid.org/0000-0003-1998-0996","observed_orcids":["https://orcid.org/0000-0003-1998-0996"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Matsuura","raw_affiliation_strings":["Department of Physiology, Shiga University of Medical Science, Shiga 520-2192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Shiga University of Medical Science, Shiga 520-2192, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012409992","display_name":"Wei\u2010Guang Ding","orcid":"https://orcid.org/0000-0001-6710-5489","observed_orcids":["https://orcid.org/0000-0001-6710-5489"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wei-Guang Ding","raw_affiliation_strings":["Department of Physiology, Shiga University of Medical Science, Shiga 520-2192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Shiga University of Medical Science, Shiga 520-2192, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432789","display_name":"Peng Li","orcid":"https://orcid.org/0000-0003-4530-2400","observed_orcids":["https://orcid.org/0000-0003-4530-2400"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110449340","display_name":"Shuang Jiang","orcid":"https://orcid.org/0000-0001-5691-7983","observed_orcids":["https://orcid.org/0000-0001-5691-7983"]},"institutions":[{"id":"https://openalex.org/I121691239","display_name":"Beihua University","ror":"https://ror.org/013jjp941","country_code":"CN","type":"education","lineage":["https://openalex.org/I121691239"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Jiang","raw_affiliation_strings":["Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China","institution_ids":["https://openalex.org/I121691239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102401731","display_name":"Bairong Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bai-Rong Du","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101665024","display_name":"Peige Du","orcid":"https://orcid.org/0000-0002-3074-6861","observed_orcids":["https://orcid.org/0000-0002-3074-6861"]},"institutions":[{"id":"https://openalex.org/I121691239","display_name":"Beihua University","ror":"https://ror.org/013jjp941","country_code":"CN","type":"education","lineage":["https://openalex.org/I121691239"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei-Ge Du","raw_affiliation_strings":["Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Jilin 132001, China","institution_ids":["https://openalex.org/I121691239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062112272","display_name":"Xun Zhu","orcid":"https://orcid.org/0000-0003-2407-2060","observed_orcids":["https://orcid.org/0000-0003-2407-2060"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xun Zhu","raw_affiliation_strings":["Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062112272","https://openalex.org/A5101665024"],"corresponding_institution_ids":["https://openalex.org/I121691239","https://openalex.org/I194450716"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"6","first_page":"6996","last_page":"6996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/octapeptide","display_name":"octapeptide","score":0.7879999876022339},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hcclm3-cells","display_name":"HCCLM3 cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mmp-2-expression","display_name":"MMP-2 expression","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.6809999942779541},{"id":"https://openalex.org/keywords/author-name-correction","display_name":"author name correction","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7044788599014282},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7024828195571899},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5508695244789124},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.471633642911911},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4576086699962616},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.44934120774269104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4069450795650482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3823864758014679},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37467944622039795},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33511602878570557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3253241777420044},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3201737403869629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.317943274974823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2783581614494324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2016504406929016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1427575945854187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1384255588054657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1280134618282318},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules17066996","doi":"https://doi.org/10.3390/molecules17066996","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules17066996","pdf_url":"https://www.mdpi.com/1420-3049/17/6/6996/pdf?version=1403113768","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5258453","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6269009","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6269009","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6269009/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d78c84bf5e8048cf938b4f5b9238425d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d78c84bf5e8048cf938b4f5b9238425d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 17, Iss 6, Pp 6996-6996 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules17066996","doi":"https://doi.org/10.3390/molecules17066996","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules17066996","pdf_url":"https://www.mdpi.com/1420-3049/17/6/6996/pdf?version=1403113768","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000239018.pdf","grobid_xml":"https://content.openalex.org/works/W2000239018.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2093078132"],"related_works":["https://openalex.org/W2093078132","https://openalex.org/W2972705463","https://openalex.org/W2366248799","https://openalex.org/W2906153142","https://openalex.org/W2108409152","https://openalex.org/W3173134192","https://openalex.org/W1975555969","https://openalex.org/W6944168492","https://openalex.org/W2946038132","https://openalex.org/W3183502829"],"abstract_inverted_index":{"The":[0],"authors":[1],"wish":[2],"to":[3,8],"make":[4],"the":[5,12,16],"following":[6],"correction":[7],"this":[9],"paper":[10],"[1]:":[11],"correct":[13],"name":[14],"of":[15],"fourth":[17],"author":[18],"is":[19],"Hiroshi":[20],"Matsuura.":[21],"[...]":[22]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}