{"id":"https://openalex.org/W2000229232","doi":"https://doi.org/10.1016/j.molstruc.2014.11.010","title":"Temperature induced structural transitions from native to unfolded aggregated states of tobacco etch virus protease","display_name":"Temperature induced structural transitions from native to unfolded aggregated states of tobacco etch virus protease","publication_year":2014,"publication_date":"2014-11-11","ids":{"openalex":"https://openalex.org/W2000229232","doi":"https://doi.org/10.1016/j.molstruc.2014.11.010","mag":"2000229232"},"language":"en","primary_location":{"id":"doi:10.1016/j.molstruc.2014.11.010","doi":"https://doi.org/10.1016/j.molstruc.2014.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2014.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110082007","display_name":"Guo-Fei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Fei Zhu","raw_affiliation_strings":["Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089844780","display_name":"Siyan Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Yan Ren","raw_affiliation_strings":["Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101598720","display_name":"Lei Xi","orcid":"https://orcid.org/0009-0004-1414-6294","observed_orcids":["https://orcid.org/0009-0004-1414-6294"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xi","raw_affiliation_strings":["Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101778244","display_name":"Linfang Du","orcid":"https://orcid.org/0000-0001-6961-9221","observed_orcids":["https://orcid.org/0000-0001-6961-9221"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin-Fang Du","raw_affiliation_strings":["Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-Resources and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078371318","display_name":"Xiaofeng Zhu","orcid":"https://orcid.org/0000-0002-1248-4247","observed_orcids":["https://orcid.org/0000-0002-1248-4247"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Feng Zhu","raw_affiliation_strings":["Center for Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu 610064, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu 610064, PR China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078371318","https://openalex.org/A5101778244"],"corresponding_institution_ids":["https://openalex.org/I24185976"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.3665,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57199921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1082","issue":null,"first_page":"80","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tobacco-etch-virus-protease","display_name":"tobacco etch virus protease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/three-state-unfolding","display_name":"three-state unfolding","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protein-unfolding-intermediates","display_name":"unfolding intermediates","score":0.6430000066757202},{"id":"https://openalex.org/keywords/reversible-unfolding","display_name":"reversible unfolding","score":0.5389999747276306},{"id":"https://openalex.org/keywords/irreversible-unfolding","display_name":"irreversible unfolding","score":0.6729999780654907},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.546999990940094},{"id":"https://openalex.org/keywords/alpha-helix-to-beta-sheet-transition","display_name":"alpha-helix to beta-sheet transition","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9228380918502808},{"id":"https://openalex.org/C2778896982","wikidata":"https://www.wikidata.org/wiki/Q2033625","display_name":"Thioflavin","level":4,"score":0.6611827611923218},{"id":"https://openalex.org/C2777833472","wikidata":"https://www.wikidata.org/wiki/Q3560918","display_name":"Tobacco etch virus","level":5,"score":0.631612241268158},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6007559895515442},{"id":"https://openalex.org/C2779155187","wikidata":"https://www.wikidata.org/wiki/Q114391","display_name":"Congo red","level":3,"score":0.5667242407798767},{"id":"https://openalex.org/C19472624","wikidata":"https://www.wikidata.org/wiki/Q583851","display_name":"Native state","level":2,"score":0.5419912934303284},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4787577688694},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4787563681602478},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47823160886764526},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.4633271098136902},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.46246853470802307},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4506152868270874},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.41617274284362793},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3590812087059021},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.21309703588485718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19809705018997192},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16469824314117432},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15305033326148987},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.11379799246788025},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776625791","wikidata":"https://www.wikidata.org/wiki/Q3400142","display_name":"Potyvirus","level":4,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C109110057","wikidata":"https://www.wikidata.org/wiki/Q1495434","display_name":"Plant virus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molstruc.2014.11.010","doi":"https://doi.org/10.1016/j.molstruc.2014.11.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molstruc.2014.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S203479135","display_name":"Journal of Molecular Structure","issn_l":"0022-2860","issn":["0022-2860","1872-8014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Structure","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W133766157","https://openalex.org/W1548535208","https://openalex.org/W1967307798","https://openalex.org/W1980310967","https://openalex.org/W1980767889","https://openalex.org/W1989270637","https://openalex.org/W1989297730","https://openalex.org/W2005991886","https://openalex.org/W2009723835","https://openalex.org/W2014095962","https://openalex.org/W2027563574","https://openalex.org/W2032804864","https://openalex.org/W2036644638","https://openalex.org/W2041428973","https://openalex.org/W2045389690","https://openalex.org/W2046798984","https://openalex.org/W2048691228","https://openalex.org/W2050674574","https://openalex.org/W2055827177","https://openalex.org/W2058469726","https://openalex.org/W2058851167","https://openalex.org/W2060085692","https://openalex.org/W2064892338","https://openalex.org/W2070830937","https://openalex.org/W2075797891","https://openalex.org/W2078337211","https://openalex.org/W2079800679","https://openalex.org/W2084808709","https://openalex.org/W2089305454","https://openalex.org/W2090319817","https://openalex.org/W2094500627","https://openalex.org/W2108107378","https://openalex.org/W2109864603","https://openalex.org/W2111010372","https://openalex.org/W2115537581","https://openalex.org/W2116556142","https://openalex.org/W2120717592","https://openalex.org/W2121753059","https://openalex.org/W2129995310","https://openalex.org/W2132981976","https://openalex.org/W2142633082","https://openalex.org/W2142843496","https://openalex.org/W2144735558","https://openalex.org/W2149138461","https://openalex.org/W2150708096","https://openalex.org/W2153439292","https://openalex.org/W2154255598","https://openalex.org/W2156205968","https://openalex.org/W2160898059","https://openalex.org/W2161323536","https://openalex.org/W2164623788","https://openalex.org/W2165307962","https://openalex.org/W2166745505","https://openalex.org/W2465858892","https://openalex.org/W2491458126","https://openalex.org/W3024136902","https://openalex.org/W3086983054"],"related_works":["https://openalex.org/W4307642801","https://openalex.org/W1990939643","https://openalex.org/W14541597","https://openalex.org/W4237512618","https://openalex.org/W2175072675","https://openalex.org/W322143362","https://openalex.org/W1997830142","https://openalex.org/W2332527735","https://openalex.org/W3029029764","https://openalex.org/W2093663538"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}