{"id":"https://openalex.org/W2000219915","doi":"https://doi.org/10.1021/jm0005510","title":"Synthesis, Photophysical Properties, Tumor Uptake, and Preliminary in Vivo Photosensitizing Efficacy of a Homologous Series of 3-(1\u2018-Alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with Variable Lipophilicity","display_name":"Synthesis, Photophysical Properties, Tumor Uptake, and Preliminary in Vivo Photosensitizing Efficacy of a Homologous Series of 3-(1\u2018-Alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with Variable Lipophilicity","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2000219915","doi":"https://doi.org/10.1021/jm0005510","mag":"2000219915","pmid":"https://pubmed.ncbi.nlm.nih.gov/11334564"},"language":"en","primary_location":{"id":"doi:10.1021/jm0005510","doi":"https://doi.org/10.1021/jm0005510","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0005510","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075963709","display_name":"Gang Zheng","orcid":"https://orcid.org/0000-0002-0705-7398","observed_orcids":["https://orcid.org/0000-0002-0705-7398"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Zheng","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112170510","display_name":"William R. Potter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Potter","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080402058","display_name":"Susan H. Camacho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan H. Camacho","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075359546","display_name":"Joseph R. Missert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Missert","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008184670","display_name":"Guosheng Wang","orcid":"https://orcid.org/0000-0002-9548-1657","observed_orcids":["https://orcid.org/0000-0002-9548-1657"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guosheng Wang","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065629135","display_name":"David A. Bellnier","orcid":"https://orcid.org/0000-0002-6851-816X","observed_orcids":["https://orcid.org/0000-0002-6851-816X"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bellnier","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112040346","display_name":"Barbara W. Henderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara W. Henderson","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945323","display_name":"Michael A. J. Rodgers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. J. Rodgers","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010197450","display_name":"Thomas J. Dougherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Dougherty","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035386967","display_name":"Ravindra Kumar Pandey","orcid":"https://orcid.org/0000-0002-9889-4860","observed_orcids":["https://orcid.org/0000-0002-9889-4860","https://orcid.org/0009-0009-0274-4058"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ravindra K. Pandey","raw_affiliation_strings":["Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photodynamic Therapy Center, Department of Nuclear Medicine/Radiology, Roswell Park Cancer Institute, Buffalo, New York 14263, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035386967"],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I157417397"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.4126,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.88639053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"44","issue":"10","first_page":"1540","last_page":"1559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.843999981880188},{"id":"https://openalex.org/keywords/singlet-oxygen-generation","display_name":"singlet oxygen generation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/homologous-series","display_name":"homologous series","score":0.7210000157356262},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.9645148515701294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.918886661529541},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.7875330448150635},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6016438603401184},{"id":"https://openalex.org/C2776482079","wikidata":"https://www.wikidata.org/wiki/Q741844","display_name":"Homologous series","level":2,"score":0.5309433937072754},{"id":"https://openalex.org/C2780591741","wikidata":"https://www.wikidata.org/wiki/Q899405","display_name":"Hydroxymethyl","level":2,"score":0.5215977430343628},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.4773973524570465},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44808119535446167},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21100959181785583},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.15073761343955994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077194","descriptor_name":"Chlorophyll A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002734","descriptor_name":"Chlorophyll","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026082","descriptor_name":"Singlet Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm0005510","doi":"https://doi.org/10.1021/jm0005510","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0005510","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11334564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11334564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2124458638","display_name":"PDT Optimization and Mechanisms","funder_award_id":"P01CA055791","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1987060413","https://openalex.org/W1996849243","https://openalex.org/W2001281853","https://openalex.org/W2001465232","https://openalex.org/W2003083944","https://openalex.org/W2031497180","https://openalex.org/W2039260679","https://openalex.org/W2052168361","https://openalex.org/W2053733032","https://openalex.org/W2140210736","https://openalex.org/W2329472479","https://openalex.org/W2767369023","https://openalex.org/W3110313054","https://openalex.org/W4211024586"],"related_works":["https://openalex.org/W1987060413","https://openalex.org/W1976287602","https://openalex.org/W6925210566","https://openalex.org/W1994220739","https://openalex.org/W1979925343","https://openalex.org/W7097736776","https://openalex.org/W7100391312","https://openalex.org/W2949280387","https://openalex.org/W2949699347","https://openalex.org/W2953234641"],"abstract_inverted_index":{"Starting":[0],"from":[1,79],"methylpheophorbide-a,":[2],"a":[3,80,108,141,146],"homologous":[4],"series":[5],"of":[6,49,60,82,100,149,163,177,180],"purpurinimides":[7,166],"containing":[8],"alkyl":[9,102],"substituents":[10],"at":[11,132],"two":[12],"different":[13],"positions":[14],"[as":[15],"3-(1(1)-O-alkyl)":[16],"and":[17,57,98,119,135,153,156,167,184],"13(2)-N-alkyl]":[18],"were":[19,63],"synthesized.":[20],"These":[21],"compounds":[22,62],"with":[23,41,84],"variable":[24],"lipophilicity":[25,86],"(log":[26,87],"P":[27,88],"5.32-16.44)":[28],"exhibit":[29],"long":[30],"wavelength":[31],"absorption":[32],"near":[33],"lambda(max)700":[34],"nm":[35],"(epsilon:":[36],"45":[37],"000":[38],"in":[39,46,53,54,65,72,107,114,120],"dichloromethane)":[40],"singlet":[42],"oxygen":[43],"((1)O2)":[44],"production":[45],"the":[47,93,96,101,161,164,168,178,181],"range":[48],"57-60%.":[50],"The":[51,76,151,175],"shifts":[52],"vivo":[55,73,121],"absorptions":[56],"tumor/skin":[58],"uptake":[59],"these":[61],"determined":[64],"C3H":[66],"mice":[67],"bearing":[68],"RIF":[69],"tumors":[70],"by":[71],"reflectance":[74],"spectroscopy.":[75],"results":[77],"obtained":[78],"set":[81,148],"photosensitizers":[83],"similar":[85],"10.68-10.88)":[89],"indicate":[90],"that":[91],"besides":[92],"overall":[94],"lipophilicity,":[95],"presence":[97],"position":[99],"groups":[103],"(O-alkyl":[104],"vs":[105],"N-alkyl)":[106],"molecule":[109],"play":[110],"an":[111],"important":[112],"role":[113],"tumor":[115,117],"uptake,":[116],"selectivity,":[118],"PDT":[122],"efficacy.":[123],"At":[124],"present,":[125],"all":[126],"purpurinimide":[127],"analogues":[128],"are":[129,137,190],"being":[130],"evaluated":[131],"various":[133,172],"doses,":[134],"experiments":[136],"underway":[138],"to":[139],"establish":[140],"quantitative":[142],"structure-activity":[143],"relationship":[144],"on":[145],"limited":[147],"compounds.":[150],"1D":[152],"2D":[154],"NMR":[155],"mass":[157],"spectrometry":[158],"analyses":[159],"confirmed":[160],"structures":[162],"desired":[165],"byproducts":[169],"formed":[170],"during":[171],"reaction":[173,188],"conditions.":[174],"mechanisms":[176],"formation":[179],"unexpected":[182],"12-formyl-":[183],"12-(hydroxymethyl)purpurinimides":[185],"under":[186],"certain":[187],"conditions":[189],"also":[191],"discussed.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":47},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
