{"id":"https://openalex.org/W2000216983","doi":"https://doi.org/10.1089/ten.1996.2.209","title":"Glycosaminoglycan Content of Small Intestinal Submucosa: A Bioscaffold for Tissue Replacement","display_name":"Glycosaminoglycan Content of Small Intestinal Submucosa: A Bioscaffold for Tissue Replacement","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2000216983","doi":"https://doi.org/10.1089/ten.1996.2.209","mag":"2000216983","pmid":"https://pubmed.ncbi.nlm.nih.gov/19877943"},"language":"en","primary_location":{"id":"doi:10.1089/ten.1996.2.209","doi":"https://doi.org/10.1089/ten.1996.2.209","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.1996.2.209","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000216983"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035237471","display_name":"Jason P. Hodde","orcid":"https://orcid.org/0000-0002-7588-8476","observed_orcids":["https://orcid.org/0000-0002-7588-8476"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason P. Hodde","raw_affiliation_strings":["Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073097748","display_name":"Stephen F. Badylak","orcid":"https://orcid.org/0000-0003-3555-0689","observed_orcids":["https://orcid.org/0000-0003-3555-0689"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen F. Badylak","raw_affiliation_strings":["Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111765160","display_name":"Andrew O. Brightman","orcid":"https://orcid.org/0000-0002-7805-3749","observed_orcids":["https://orcid.org/0000-0002-7805-3749"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew O. Brightman","raw_affiliation_strings":["Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063953835","display_name":"Sherry L. Voytik\u2010Harbin","orcid":"https://orcid.org/0000-0001-6210-3724","observed_orcids":["https://orcid.org/0000-0001-6210-3724"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry L. Voytik-Harbin","raw_affiliation_strings":["Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Indiana 47907-1293","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.896,"has_fulltext":false,"cited_by_count":309,"citation_normalized_percentile":{"value":0.69690011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"3","first_page":"209","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-intestinal-submucosa","display_name":"small intestinal submucosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8339999914169312},{"id":"https://openalex.org/keywords/uronic-acid","display_name":"uronic acid","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":1.0},{"id":"https://openalex.org/keywords/chondroitin-sulfate-a","display_name":"chondroitin sulfate A","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dermatan-sulfate","display_name":"dermatan sulfate","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratan-sulfate","display_name":"keratan sulfate","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chondroitin-sulfate-c","display_name":"chondroitin sulfate C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.6959999799728394},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bioscaffolds","display_name":"bioscaffolds","score":0.6859999895095825},{"id":"https://openalex.org/keywords/porcine-tissue","display_name":"porcine tissue","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.8288280367851257},{"id":"https://openalex.org/C2778066728","wikidata":"https://www.wikidata.org/wiki/Q2335618","display_name":"Dermatan sulfate","level":4,"score":0.7685742378234863},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7658650875091553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7227039933204651},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6761178374290466},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.6445847749710083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5958554744720459},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.5856863260269165},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.5336405038833618},{"id":"https://openalex.org/C2778230131","wikidata":"https://www.wikidata.org/wiki/Q2457767","display_name":"Keratan sulfate","level":4,"score":0.48973846435546875},{"id":"https://openalex.org/C2778284416","wikidata":"https://www.wikidata.org/wiki/Q412056","display_name":"Uronic acid","level":3,"score":0.46574437618255615},{"id":"https://openalex.org/C2776735749","wikidata":"https://www.wikidata.org/wiki/Q4862650","display_name":"Chondroitin","level":3,"score":0.4240986704826355},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.2222367823123932},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1866551637649536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12624070048332214},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1089/ten.1996.2.209","doi":"https://doi.org/10.1089/ten.1996.2.209","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.1996.2.209","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},{"id":"pmid:19877943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19877943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W36538361","https://openalex.org/W114028557","https://openalex.org/W144819428","https://openalex.org/W1480533478","https://openalex.org/W1536051969","https://openalex.org/W1550067421","https://openalex.org/W1582656672","https://openalex.org/W1592253612","https://openalex.org/W1965398932","https://openalex.org/W1966286222","https://openalex.org/W1971640461","https://openalex.org/W1974873948","https://openalex.org/W1996016116","https://openalex.org/W2001581318","https://openalex.org/W2014177969","https://openalex.org/W2029467066","https://openalex.org/W2032876761","https://openalex.org/W2035790993","https://openalex.org/W2042281237","https://openalex.org/W2046537667","https://openalex.org/W2053352199","https://openalex.org/W2068465081","https://openalex.org/W2072029917","https://openalex.org/W2074991442","https://openalex.org/W2080133860","https://openalex.org/W2085541762","https://openalex.org/W2240432631","https://openalex.org/W2397563109","https://openalex.org/W2478059266","https://openalex.org/W2790342967"],"related_works":["https://openalex.org/W183041730","https://openalex.org/W6889890833","https://openalex.org/W2922657309","https://openalex.org/W1992584877","https://openalex.org/W135934010","https://openalex.org/W2013072786","https://openalex.org/W3024767261","https://openalex.org/W2388952273","https://openalex.org/W7214818237","https://openalex.org/W982952602"],"abstract_inverted_index":{"Small":[0],"intestinal":[1],"submucosa":[2],"(SIS)":[3],"is":[4,47,71],"a":[5,15,197,201],"resorbable":[6],"biomaterial":[7,214],"that":[8,43],"induces":[9],"tissue":[10,17,45,219],"remodeling":[11,46,220],"when":[12],"used":[13],"as":[14,41],"xenogeneic":[16],"graft":[18],"in":[19,56,86,181,189,217],"animal":[20],"models":[21],"of":[22,31,36,53,65,83,116,120,127,147,156,186,192,205,210],"vascular,":[23],"urologic,":[24],"dermatologic,":[25],"neurologic,":[26],"and":[27,34,69,93,141,174,208],"orthopedic":[28],"injury.":[29],"Determination":[30],"the":[32,50,81,94,117,121,154,182,190,193,206],"composition":[33,191],"structure":[35,207],"naturally":[37,212],"occurring":[38,213],"biomaterials":[39],"such":[40],"SIS":[42,70,89,122,183,195],"promote":[44],"necessary":[48],"for":[49,98],"greater":[51],"understanding":[52,204],"their":[54],"role":[55],"wound":[57],"healing.":[58],"Since":[59],"glycosaminoglycans":[60,84],"(GAGs)":[61],"are":[62],"important":[63],"components":[64],"extracellular":[66],"matrix":[67],"(ECM)":[68],"primarily":[72],"an":[73],"ECM-based":[74],"material,":[75],"studies":[76],"were":[77,96,144,178],"performed":[78],"to":[79,108,163],"identify":[80],"species":[82],"present":[85],"SIS.":[87],"Porcine":[88],"was":[90,106],"chemically":[91],"extracted":[92],"extracts":[95],"analyzed":[97],"uronic":[99,103],"acid.":[100],"The":[101],"extractable":[102],"acid":[104],"content":[105],"determined":[107],"be":[109],"47.7":[110],"micromol/g":[111],"(approximately":[112],"21":[113],"microg":[114],"GAG/mg)":[115],"dry":[118],"weight":[119],"tissue.":[123],"Using":[124],"electrophoretic":[125],"separation":[126],"GAGs":[128,149,161,188],"on":[129],"cellulose":[130],"acetate":[131],"membranes,":[132],"hyaluronic":[133],"acid,":[134],"heparin,":[135],"heparan":[136],"sulfate,":[137],"chondroitin":[138,175],"sulfate":[139,143,173,176],"A,":[140],"dermatan":[142],"identified.":[145],"Digestion":[146],"specific":[148,187],"with":[150,166,215],"selective":[151],"enzymes":[152],"confirmed":[153],"presence":[155],"these":[157],"GAG":[158],"species.":[159],"Two":[160],"common":[162],"other":[164],"tissues":[165],"large":[167],"basement":[168],"membrane":[169],"ECM":[170],"components,":[171],"keratan":[172],"C,":[177],"not":[179],"detected":[180],"extracts.":[184],"Identification":[185],"ECM-rich":[194],"provides":[196],"starting":[198],"point":[199],"toward":[200],"more":[202],"comprehensive":[203],"function":[209],"this":[211],"favorable":[216],"vivo":[218],"properties.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}