{"id":"https://openalex.org/W2000210577","doi":"https://doi.org/10.1080/15622970701332520","title":"Lamotrigine in motor and mood symptoms of Huntington's disease","display_name":"Lamotrigine in motor and mood symptoms of Huntington's disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2000210577","doi":"https://doi.org/10.1080/15622970701332520","mag":"2000210577","pmid":"https://pubmed.ncbi.nlm.nih.gov/17853293"},"language":"en","primary_location":{"id":"doi:10.1080/15622970701332520","doi":"https://doi.org/10.1080/15622970701332520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15622970701332520","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000210577"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079514521","display_name":"Yu\u2010Chih Shen","orcid":"https://orcid.org/0000-0002-3503-5778","observed_orcids":["https://orcid.org/0000-0002-3503-5778"]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]},{"id":"https://openalex.org/I4210123378","display_name":"Hualien Tzu Chi Medical Center","ror":"https://ror.org/030k6vb67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210123378"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu-Chih Shen","raw_affiliation_strings":["Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC. shengmp@so-net.net.tw","Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC","Department of Psychiatry, Tzu-Chi University, Hualien City, Taiwan, ROC","Graduate Institute of Human Genetics, Tzu-Chi University, Hualien City, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC. shengmp@so-net.net.tw","institution_ids":["https://openalex.org/I4210123378"]},{"raw_affiliation_string":"Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC","institution_ids":["https://openalex.org/I4210123378"]},{"raw_affiliation_string":"Department of Psychiatry, Tzu-Chi University, Hualien City, Taiwan, ROC","institution_ids":["https://openalex.org/I189772984"]},{"raw_affiliation_string":"Graduate Institute of Human Genetics, Tzu-Chi University, Hualien City, Taiwan, ROC","institution_ids":["https://openalex.org/I189772984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079514521"],"corresponding_institution_ids":["https://openalex.org/I189772984","https://openalex.org/I4210123378"],"apc_list":null,"apc_paid":null,"fwci":0.4922,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.56202732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"2","first_page":"147","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/choreoathetosis","display_name":"choreoathetosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mood-swings","display_name":"mood swings","score":0.7419999837875366},{"id":"https://openalex.org/keywords/suicide-risk","display_name":"suicide risk","score":0.6269999742507935},{"id":"https://openalex.org/keywords/glutamate-receptor-antagonists","display_name":"glutamate receptor antagonists","score":0.7289999723434448},{"id":"https://openalex.org/keywords/motor-symptoms","display_name":"motor symptoms","score":0.6690000295639038},{"id":"https://openalex.org/keywords/psychiatric-symptoms","display_name":"psychiatric symptoms","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.9436227083206177},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.6919140219688416},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.6143162846565247},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6116316318511963},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.5466620326042175},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5224722623825073},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4963272213935852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4406566023826599},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42383432388305664},{"id":"https://openalex.org/C2778722290","wikidata":"https://www.wikidata.org/wiki/Q7933601","display_name":"Mood swing","level":3,"score":0.4106060266494751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3479178249835968},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12238618731498718},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0856231153011322},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077213","descriptor_name":"Lamotrigine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002819","descriptor_name":"Chorea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002819","descriptor_name":"Chorea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/15622970701332520","doi":"https://doi.org/10.1080/15622970701332520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15622970701332520","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:17853293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17853293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1530651870","https://openalex.org/W1982910974","https://openalex.org/W2018567081","https://openalex.org/W2043129828","https://openalex.org/W2061070907","https://openalex.org/W2080465688","https://openalex.org/W2082056883","https://openalex.org/W2084399232","https://openalex.org/W2109255570","https://openalex.org/W2115953191","https://openalex.org/W2121642311","https://openalex.org/W2153754131","https://openalex.org/W2162501631","https://openalex.org/W2416772009","https://openalex.org/W4206144694"],"related_works":["https://openalex.org/W2153754131","https://openalex.org/W2124486047","https://openalex.org/W4283157144","https://openalex.org/W1770363908","https://openalex.org/W4391774822","https://openalex.org/W3176791171","https://openalex.org/W2095238537","https://openalex.org/W2065500745","https://openalex.org/W2168512905","https://openalex.org/W4388714805"],"abstract_inverted_index":{"Huntington's":[0],"disease":[1],"(HD)":[2],"is":[3,31],"an":[4,67],"autosomal":[5],"dominant":[6],"neurodegenerative":[7],"disorder":[8],"characterized":[9],"by":[10,76],"midlife":[11],"onset,":[12],"progressive":[13],"course":[14],"and":[15,21,83,96,122],"a":[16,36],"combination":[17],"of":[18,26,39,43,55,61,66,87,104,136],"motor,":[19],"cognitive":[20],"psychiatric":[22,77],"symptoms.":[23,124],"Since":[24],"dysregulation":[25],"the":[27,59,64],"glutamate/calcium":[28],"signalling":[29],"pathway":[30],"beginning":[32],"to":[33,130],"emerge":[34],"as":[35,47],"potential":[37],"cause":[38],"neuron":[40],"degeneration,":[41],"antagonists":[42],"glutamate":[44],"pathways":[45],"such":[46],"lamotrigine,":[48],"may":[49],"have":[50],"beneficial":[51],"value":[52],"for":[53],"treatment":[54,65],"HD.":[56],"We":[57],"describe":[58],"use":[60],"lamotrigine":[62,112],"in":[63,116,134],"HD":[68,118],"patient":[69,109],"with":[70,101,120],"motor":[71,121],"abnormality":[72],"(choreoathetoidic":[73],"movements)":[74],"complicated":[75],"abnormalities":[78],"(depression,":[79],"severe":[80,93],"mood":[81,94,123],"swing":[82,95],"recurrent":[84],"high":[85],"risk":[86],"suicidal":[88],"attempts).":[89],"The":[90],"patient's":[91],"depression,":[92],"choreoathetoidic":[97],"movements":[98],"significantly":[99],"improved":[100],"300":[102],"mg/day":[103],"lamotrigine.":[105],"Experience":[106],"from":[107],"our":[108],"suggests":[110],"that":[111],"might":[113],"be":[114],"effective":[115],"treating":[117],"patients":[119,135],"Further":[125],"controlled":[126],"studies":[127],"are":[128],"warranted":[129],"confirm":[131],"its":[132],"efficacy":[133],"this":[137],"type.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
