{"id":"https://openalex.org/W2000208351","doi":"https://doi.org/10.1016/j.acn.2007.04.003","title":"Specificity of frontal dysfunctions in relapsing\u2013remitting multiple sclerosis","display_name":"Specificity of frontal dysfunctions in relapsing\u2013remitting multiple sclerosis","publication_year":2007,"publication_date":"2007-05-08","ids":{"openalex":"https://openalex.org/W2000208351","doi":"https://doi.org/10.1016/j.acn.2007.04.003","mag":"2000208351","pmid":"https://pubmed.ncbi.nlm.nih.gov/17482795"},"language":"en","primary_location":{"id":"doi:10.1016/j.acn.2007.04.003","doi":"https://doi.org/10.1016/j.acn.2007.04.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.acn.2007.04.003","pdf_url":null,"source":{"id":"https://openalex.org/S13265631","display_name":"Archives of Clinical Neuropsychology","issn_l":"0887-6177","issn":["0887-6177","1873-5843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Clinical Neuropsychology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"O SANTIAGO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"O SANTIAGO","raw_affiliation_strings":["Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat, Barcelona, Spain. osantiago@campus.uoc.es","Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat, Barcelona, Spain. osantiago@campus.uoc.es","institution_ids":["https://openalex.org/I2802050225"]},{"raw_affiliation_string":"Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J GUARDIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J GUARDIA","raw_affiliation_strings":["Departament de Metodologia de les Ci\u00e8ncies del Comportament, Facultat de Psicologia, Universitat de Barcelona 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Metodologia de les Ci\u00e8ncies del Comportament, Facultat de Psicologia, Universitat de Barcelona 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014120575","display_name":"Virginia Casado","orcid":"https://orcid.org/0000-0002-3079-8776","observed_orcids":["https://orcid.org/0000-0002-3079-8776"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V CASADO","raw_affiliation_strings":["Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008318232","display_name":"Olga Carmona","orcid":"https://orcid.org/0000-0002-5957-0046","observed_orcids":["https://orcid.org/0000-0002-5957-0046"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"O CARMONA","raw_affiliation_strings":["Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de Llobregat Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111956962","display_name":"Txomin Arbizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"T ARBIZU","raw_affiliation_strings":["Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de LlobregatBarcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat d'Esclerosi M\u00faltiple, Servei de Neurologia, Hospital de Bellvitge, Feixa Llarga s/n E-08907, L'Hospitalet de LlobregatBarcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802050225"],"apc_list":{"value":4823,"currency":"USD","value_usd":4823},"apc_paid":null,"fwci":1.1034,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.77242937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"22","issue":"5","first_page":"623","last_page":"629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13471","display_name":"Cognitive Functions and Memory","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/frontal-lobe-dysfunction","display_name":"frontal lobe dysfunction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.5759999752044678},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.9359999895095825},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arithmetic-skills","display_name":"arithmetic skills","score":0.4059999883174896},{"id":"https://openalex.org/keywords/wisconsin-card-sorting-test","display_name":"Wisconsin Card Sorting Test","score":0.75}],"concepts":[{"id":"https://openalex.org/C3020694758","wikidata":"https://www.wikidata.org/wiki/Q42417392","display_name":"Relapsing remitting","level":3,"score":0.9523202776908875},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8648200035095215},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5238093137741089},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4182218611240387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40137866139411926},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2050485908985138}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000339","descriptor_name":"Affect","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004193","descriptor_name":"Discrimination Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011340","descriptor_name":"Problem Solving","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.acn.2007.04.003","doi":"https://doi.org/10.1016/j.acn.2007.04.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.acn.2007.04.003","pdf_url":null,"source":{"id":"https://openalex.org/S13265631","display_name":"Archives of Clinical Neuropsychology","issn_l":"0887-6177","issn":["0887-6177","1873-5843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Clinical Neuropsychology","raw_type":"journal-article"},{"id":"pmid:17482795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17482795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1966366939","https://openalex.org/W1972013249","https://openalex.org/W1972672792","https://openalex.org/W1976323490","https://openalex.org/W1977455820","https://openalex.org/W1985754065","https://openalex.org/W1990755823","https://openalex.org/W1990922727","https://openalex.org/W1996028241","https://openalex.org/W1996493051","https://openalex.org/W1997390910","https://openalex.org/W1997621686","https://openalex.org/W1997697006","https://openalex.org/W2000399989","https://openalex.org/W2012132621","https://openalex.org/W2023307073","https://openalex.org/W2025070618","https://openalex.org/W2026040424","https://openalex.org/W2026151801","https://openalex.org/W2028682482","https://openalex.org/W2029484092","https://openalex.org/W2029898151","https://openalex.org/W2033980230","https://openalex.org/W2036681067","https://openalex.org/W2041731350","https://openalex.org/W2047226578","https://openalex.org/W2048905533","https://openalex.org/W2049904609","https://openalex.org/W2049973719","https://openalex.org/W2052767160","https://openalex.org/W2060129459","https://openalex.org/W2060322616","https://openalex.org/W2067201200","https://openalex.org/W2068503612","https://openalex.org/W2087423635","https://openalex.org/W2095387838","https://openalex.org/W2096420290","https://openalex.org/W2103029732","https://openalex.org/W2104578899","https://openalex.org/W2112165124","https://openalex.org/W2130355701","https://openalex.org/W2132659484","https://openalex.org/W2135143862","https://openalex.org/W2140843068","https://openalex.org/W2146057830","https://openalex.org/W3083636536","https://openalex.org/W4229625885","https://openalex.org/W4237269015"],"related_works":["https://openalex.org/W1572723159","https://openalex.org/W2057440351","https://openalex.org/W2925071731","https://openalex.org/W2157341252","https://openalex.org/W2750330886","https://openalex.org/W1937817990","https://openalex.org/W2043798805","https://openalex.org/W2068952669","https://openalex.org/W2029484092","https://openalex.org/W1990755823"],"abstract_inverted_index":{"Various":[0],"studies":[1],"have":[2,69],"reported":[3],"deficits":[4],"in":[5,9,37,75,124],"frontal":[6,17,35,66,139],"cognitive":[7],"functions":[8,36,67,134],"patients":[10,42],"with":[11,43,118],"multiple":[12,45],"sclerosis":[13,46],"(MS).":[14],"However,":[15],"the":[16,48,65,82,89,93,99,106,110,121,138],"deficit":[18],"is":[19,23],"not":[20],"uniform":[21],"and":[22,85,98,130,141],"often":[24],"very":[25],"subtle.":[26],"The":[27,51],"aim":[28],"of":[29,41,56,101,109,126],"this":[30],"study":[31],"was":[32],"to":[33,104,120],"assess":[34],"a":[38,54,61],"broad":[39],"sample":[40,52],"relapsing-remitting":[44],"at":[47],"mild-to-moderate":[49],"stage.":[50],"included":[53],"series":[55],"165":[57],"patients.":[58],"We":[59],"used":[60],"test":[62],"battery":[63],"covering":[64],"that":[68],"been":[70],"described":[71],"as":[72],"being":[73],"altered":[74],"MS.":[76],"Significant":[77],"differences":[78,117],"were":[79],"found":[80],"between":[81,137],"patient":[83],"group":[84,123],"healthy":[86],"controls":[87],"on":[88],"WAIS":[90],"Arithmetic":[91],"subtest,":[92],"PASAT,":[94],"category":[95,108],"word":[96],"recall":[97],"number":[100],"trials":[102],"required":[103],"reach":[105],"first":[107],"WCST.":[111],"In":[112],"conclusion,":[113],"we":[114],"observed":[115],"significant":[116],"respect":[119],"control":[122],"terms":[125],"information":[127],"processing":[128],"speed":[129],"working":[131],"memory.":[132],"These":[133],"involve":[135],"connections":[136],"lobe":[140],"other":[142],"brain":[143],"regions.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}