{"id":"https://openalex.org/W2000160845","doi":"https://doi.org/10.1259/bjr.74.878.740177","title":"Evaluation of the optimal co-planar field arrangement for use in the boost phase of dose escalated conformal radiotherapy for localized prostate cancer","display_name":"Evaluation of the optimal co-planar field arrangement for use in the boost phase of dose escalated conformal radiotherapy for localized prostate cancer","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2000160845","doi":"https://doi.org/10.1259/bjr.74.878.740177","mag":"2000160845","pmid":"https://pubmed.ncbi.nlm.nih.gov/11718391"},"language":"en","primary_location":{"id":"doi:10.1259/bjr.74.878.740177","doi":"https://doi.org/10.1259/bjr.74.878.740177","is_oa":false,"landing_page_url":"https://doi.org/10.1259/bjr.74.878.740177","pdf_url":null,"source":{"id":"https://openalex.org/S142542876","display_name":"British Journal of Radiology","issn_l":"0007-1285","issn":["0007-1285","1748-880X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British Journal of Radiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080362183","display_name":"Vincent S Khoo","orcid":"https://orcid.org/0000-0002-0763-6832","observed_orcids":["https://orcid.org/0000-0002-0763-6832"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V S Khoo","raw_affiliation_strings":["The Academic Unit of Radiotherapy & Oncology, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK","The Academic Unit of Radiotherapy & Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Academic Unit of Radiotherapy & Oncology, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"The Academic Unit of Radiotherapy & Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108251577","display_name":"J. L. Bedford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J L Bedford","raw_affiliation_strings":["The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109077806","display_name":"S Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Webb","raw_affiliation_strings":["The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025921361","display_name":"David Paul Dearnaley","orcid":"https://orcid.org/0000-0002-3954-2806","observed_orcids":["https://orcid.org/0000-0002-3954-2806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D P Dearnaley","raw_affiliation_strings":["The Academic Unit of Radiotherapy & Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Academic Unit of Radiotherapy & Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2279,"currency":"GBP","value_usd":3005},"apc_paid":null,"fwci":1.9948,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84870364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"74","issue":"878","first_page":"177","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/radiotherapy-boost","display_name":"boost radiotherapy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/conformal-radiotherapy","display_name":"conformal radiotherapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rectal-dose","display_name":"rectal dose","score":0.7260000109672546},{"id":"https://openalex.org/keywords/bladder-dose","display_name":"bladder dose","score":0.8840000033378601},{"id":"https://openalex.org/keywords/femoral-head-dose","display_name":"femoral head dose","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rectal-toxicity","display_name":"rectal toxicity","score":0.3529999852180481},{"id":"https://openalex.org/keywords/bladder-toxicity","display_name":"bladder toxicity","score":0.48899999260902405},{"id":"https://openalex.org/keywords/dose-volume-analysis","display_name":"dose-volume analysis","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C208081375","wikidata":"https://www.wikidata.org/wiki/Q274502","display_name":"Degrees of freedom (physics and chemistry)","level":2,"score":0.6842800974845886},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5088694095611572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48088982701301575},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4788898527622223},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4286061227321625},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3812006711959839},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23677566647529602},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1105729341506958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07975614070892334},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005270","descriptor_name":"Femur Head","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1259/bjr.74.878.740177","doi":"https://doi.org/10.1259/bjr.74.878.740177","is_oa":false,"landing_page_url":"https://doi.org/10.1259/bjr.74.878.740177","pdf_url":null,"source":{"id":"https://openalex.org/S142542876","display_name":"British Journal of Radiology","issn_l":"0007-1285","issn":["0007-1285","1748-880X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British Journal of Radiology","raw_type":"journal-article"},{"id":"pmid:11718391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11718391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of radiology","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1963852792","https://openalex.org/W1968757243","https://openalex.org/W1982003181","https://openalex.org/W1982675823","https://openalex.org/W2004006404","https://openalex.org/W2004250124","https://openalex.org/W2022409747","https://openalex.org/W2025027678","https://openalex.org/W2033456044","https://openalex.org/W2071238711","https://openalex.org/W2077239666","https://openalex.org/W2097512974","https://openalex.org/W2098507748","https://openalex.org/W2098668128","https://openalex.org/W2118352314","https://openalex.org/W2163217542"],"related_works":["https://openalex.org/W1968757243","https://openalex.org/W2022409747","https://openalex.org/W2008067575","https://openalex.org/W2050577661","https://openalex.org/W2334021338","https://openalex.org/W2036527216","https://openalex.org/W2098668128","https://openalex.org/W2152693343","https://openalex.org/W2520992332","https://openalex.org/W2026170121"],"abstract_inverted_index":{"The":[0,143,211,311],"aim":[1],"of":[2,16,29,128,161,173,352],"this":[3],"study":[4],"was":[5,269,284,293,303,344],"to":[6,136,165,228,288,297,307,333],"determine":[7],"the":[8,26,137,149,174,183,187,239,243,246,266,272,281,290,300,315,323,328,336,369],"optimal":[9,192,341],"co-planar":[10,337],"beam":[11,347,383],"arrangement":[12,348,384],"from":[13,286,295,305,330],"a":[14,30,154,345],"variety":[15],"three-field":[17],"(3F),":[18],"four-field":[19],"(4F)":[20],"and":[21,57,109,131,170,186,195,203,233,299,314,357,392,395],"six-field":[22],"(6F)":[23],"plans":[24,38,76,197,241],"for":[25,182,265],"boost":[27,144,267,324],"phase":[28,268,325],"dose":[31,329],"escalated":[32],"conformal":[33],"radiotherapy":[34],"schedule.":[35],"Three":[36],"selected":[37],"(3F":[39,77],"0":[40,78,86,353],"degrees,":[41,43,49,51,53,60,62,64,66,68,79,81,87,89,91,97,99,101,103,105,112,114,116,118,120,214,216,249,251,253,255,257,275,277,354,372,374,376,378,380],"90":[42,50,61,88,98,113,215,250,276,355,373],"270":[44,52,67,92,104,119,217,256,278,358,379],"degrees":[45,55,70,83,93,107,122,356],"plan,":[46,84,94,280],"4F":[47,85,194],"45":[48],"315":[54],"plan":[56,108,219,260,338,362],"6F":[58,95,110,196,247,370],"40":[59],"115":[63],"245":[65],"320":[69],"plan)":[71,123],"were":[72,134,157,179,320],"compared":[73,158,237,270,367],"with":[74,230,238,271,368,390],"reference":[75,209],"120":[80],"240":[82],"180":[90],"55":[96],"125":[100],"235":[102],"305":[106],"50":[111],"130":[115,252,375],"230":[117,254,377],"310":[121,258,381],"in":[124,242],"10":[125],"patients.":[126],"Doses":[127],"64":[129,331],"Gy":[130,133,332],"74":[132,334],"prescribed":[135,175],"isocentre":[138],"using":[139,349],"6":[140],"MV":[141],"photons.":[142],"planning":[145],"target":[146],"volume":[147],"comprised":[148],"prostate":[150],"gland":[151],"alone":[152],"without":[153],"margin.":[155],"Plans":[156],"by":[159],"means":[160],"rectal":[162,201,224,282,291,301,342,365],"volumes":[163,178],"irradiated":[164,200,223],">50%":[166],"(V50),":[167],">80%":[168],"(V80)":[169],">90%":[171],"(V90)":[172,185],"dose.":[176],"Irradiated":[177],"also":[180],"measured":[181],"bladder":[184,232,312,394],"femoral":[188,234,316,396],"heads":[189,317],"(V70).":[190],"All":[191],"3F,":[193],"gave":[198],"lower":[199,222],"V80":[202,292],"V90":[204,302,313],"levels":[205,225,319],"than":[206],"their":[207],"corresponding":[208],"plan.":[210],"3F":[212,273,346,361],"(0":[213,274],"degrees)":[218,259,279,382],"consistently":[220],"provided":[221,363],"at":[226,262,387],"V50":[227,283],"V90,":[229],"acceptable":[231,393],"head":[235,397],"doses":[236],"other":[240],"study.":[244],"When":[245],"(50":[248,371],"used":[261,386],"our":[263,388],"institution":[264],"reduced":[285,294,304],"20.8+/-5.2%,":[287],"12.6+/-5.1%,":[289],"8.7+/-2.9%":[296],"6.5+/-3.1%":[298],"5.5+/-2.1%":[306],"3.9+/-2.0%":[308],"(all":[309],"p<0.001).":[310],"V70":[318],"equivalent.":[321],"For":[322],"when":[326],"escalating":[327],"Gy,":[335],"that":[339],"allowed":[340],"sparing":[343,366],"gantry":[350],"angles":[351],"degrees.":[359],"This":[360],"improved":[364],"currently":[385],"institution,":[389],"equivalent":[391],"doses.":[398]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}