{"id":"https://openalex.org/W2000143151","doi":"https://doi.org/10.1517/13543784.17.10.1567","title":"Prolonged-release melatonin for the treatment of insomnia in patients over 55 years","display_name":"Prolonged-release melatonin for the treatment of insomnia in patients over 55 years","publication_year":2008,"publication_date":"2008-09-22","ids":{"openalex":"https://openalex.org/W2000143151","doi":"https://doi.org/10.1517/13543784.17.10.1567","mag":"2000143151","pmid":"https://pubmed.ncbi.nlm.nih.gov/18808316"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.17.10.1567","doi":"https://doi.org/10.1517/13543784.17.10.1567","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.17.10.1567","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111522890","display_name":"Alan G. Wade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134660","display_name":"CPS Research","ror":"https://ror.org/03hmdtw84","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210134660"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Wade","raw_affiliation_strings":["CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland. alangwade@fastmail.fm","+44 0 141 946 1324","CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland. alangwade@fastmail.fm","institution_ids":["https://openalex.org/I4210134660"]},{"raw_affiliation_string":"+44 0 141 946 1324","institution_ids":[]},{"raw_affiliation_string":"CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888","institution_ids":["https://openalex.org/I4210134660"]}]},{"author_position":"last","author":{"id":null,"display_name":"Susan Downie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134660","display_name":"CPS Research","ror":"https://ror.org/03hmdtw84","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210134660"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan Downie","raw_affiliation_strings":["CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888; +44 0 141 946 1324; alangwade@fastmail.fm","+44 0 141 946 1324","CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888; +44 0 141 946 1324; alangwade@fastmail.fm","institution_ids":["https://openalex.org/I4210134660"]},{"raw_affiliation_string":"+44 0 141 946 1324","institution_ids":[]},{"raw_affiliation_string":"CPS Research, 3 Todd Campus, West of Scotland Science Park, Glasgow, G20 0KA, Scotland +44 0 141 946 7888","institution_ids":["https://openalex.org/I4210134660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210134660"],"apc_list":null,"apc_paid":null,"fwci":0.2966,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.40540541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"10","first_page":"1567","last_page":"1572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.15209999680519104,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolonged-release-melatonin","display_name":"prolonged-release melatonin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.7580000162124634},{"id":"https://openalex.org/keywords/primary-insomnia","display_name":"primary insomnia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8040000200271606},{"id":"https://openalex.org/keywords/melatonin-receptor-agonists","display_name":"melatonin receptor agonists","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.9610000252723694},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6380000114440918},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9078467488288879},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.8441572189331055},{"id":"https://openalex.org/C200678441","wikidata":"https://www.wikidata.org/wiki/Q1423044","display_name":"Alertness","level":2,"score":0.6028388738632202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5703600645065308},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.473471075296402},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4373573660850525},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.419563889503479},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4140610098838806},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35681647062301636},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.27543455362319946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2646886110305786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543784.17.10.1567","doi":"https://doi.org/10.1517/13543784.17.10.1567","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.17.10.1567","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:18808316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18808316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1156678","https://openalex.org/W49933285","https://openalex.org/W50274915","https://openalex.org/W89805643","https://openalex.org/W1518386324","https://openalex.org/W1541664791","https://openalex.org/W1693832253","https://openalex.org/W1730668751","https://openalex.org/W1799288929","https://openalex.org/W1938523556","https://openalex.org/W1972937407","https://openalex.org/W1974254409","https://openalex.org/W1976587910","https://openalex.org/W1990767182","https://openalex.org/W1994248200","https://openalex.org/W1999482712","https://openalex.org/W2006237636","https://openalex.org/W2022863381","https://openalex.org/W2031307247","https://openalex.org/W2036542466","https://openalex.org/W2037747150","https://openalex.org/W2038537304","https://openalex.org/W2042576367","https://openalex.org/W2045414046","https://openalex.org/W2047393425","https://openalex.org/W2050746954","https://openalex.org/W2054391435","https://openalex.org/W2065813249","https://openalex.org/W2073460305","https://openalex.org/W2075256377","https://openalex.org/W2080745812","https://openalex.org/W2089531750","https://openalex.org/W2098253552","https://openalex.org/W2119800398","https://openalex.org/W2135777766","https://openalex.org/W2141516733","https://openalex.org/W2151016127","https://openalex.org/W2151487996","https://openalex.org/W2165834747","https://openalex.org/W2167904944","https://openalex.org/W2434919075","https://openalex.org/W2466628650"],"related_works":["https://openalex.org/W2164814720","https://openalex.org/W2119800398","https://openalex.org/W206177870","https://openalex.org/W1989873948","https://openalex.org/W2088279489","https://openalex.org/W1999482712","https://openalex.org/W2148557042","https://openalex.org/W2039647336","https://openalex.org/W2151944611","https://openalex.org/W2057263390"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clinical":[1],"data":[2,80],"show":[3],"that":[4],"poor":[5],"quality,":[6],"rather":[7],"than":[8],"quantity,":[9],"of":[10,16,27,33,50,69,101],"sleep":[11,102],"corresponds":[12],"negatively":[13],"to":[14,57],"measures":[15],"health,":[17],"well-being":[18],"and":[19,86,99],"satisfaction":[20],"with":[21,104],"life.":[22],"However,":[23],"until":[24],"now":[25],"treatment":[26,41,68],"insomnia":[28,71],"has":[29],"primarily":[30],"targeted":[31],"quantity":[32],"sleep.":[34],"PR":[35],"(prolonged":[36],"release)-melatonin":[37],"offers":[38],"a":[39],"new":[40],"option":[42],"in":[43,62,72,82],"insomnia.":[44],"OBJECTIVES:":[45],"To":[46],"provide":[47],"an":[48],"overview":[49],"PR-melatonin,":[51],"the":[52,67,87],"first":[53],"melatonin":[54],"receptor":[55],"agonist":[56],"be":[58],"granted":[59],"marketing":[60],"authorisation":[61],"Europe":[63],"as":[64],"monotherapy":[65],"for":[66],"primary":[70],"patients":[73],"aged":[74],">":[75],"55":[76],"years.":[77],"METHODS:":[78],"Review":[79],"published":[81],"peer":[83],"review":[84],"journals":[85],"EMEA":[88],"(European":[89],"Medicines":[90],"Agency)":[91],"website.":[92],"RESULTS/CONCLUSION:":[93],"PR-melatonin":[94],"significantly":[95],"improves":[96],"morning":[97],"alertness":[98],"quality":[100],"compared":[103],"placebo.":[105],"There":[106],"are":[107],"no":[108],"safety":[109],"concerns.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}