{"id":"https://openalex.org/W2000112233","doi":"https://doi.org/10.4155/cli.12.65","title":"Clinical innovation for neurodegenerative diseases","display_name":"Clinical innovation for neurodegenerative diseases","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2000112233","doi":"https://doi.org/10.4155/cli.12.65","mag":"2000112233"},"language":"en","primary_location":{"id":"doi:10.4155/cli.12.65","doi":"https://doi.org/10.4155/cli.12.65","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.12.65","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108088008","display_name":"Olivier Blin","orcid":"https://orcid.org/0000-0003-0142-0931","observed_orcids":["https://orcid.org/0000-0003-0142-0931"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olivier Blin","raw_affiliation_strings":["GlaxoSmithKline"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019383039","display_name":"Ceri H. Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ceri H Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060056784","display_name":"Bai Lu","orcid":"https://orcid.org/0000-0001-5418-9759","observed_orcids":["https://orcid.org/0000-0001-5418-9759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bai Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2207,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.44726758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"7","first_page":"663","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9160000085830688},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.6179999709129333},{"id":"https://openalex.org/keywords/public-private-partnerships","display_name":"public-private partnerships","score":0.9210000038146973},{"id":"https://openalex.org/keywords/innovative-medicines-initiative","display_name":"Innovative Medicines Initiative","score":0.9769999980926514},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8021420836448669},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.4423527717590332},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43806129693984985},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3448852300643921},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14986154437065125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4155/cli.12.65","doi":"https://doi.org/10.4155/cli.12.65","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.12.65","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1599436846","https://openalex.org/W1973021576","https://openalex.org/W1991969068","https://openalex.org/W2058298068","https://openalex.org/W2059218490","https://openalex.org/W2107535420","https://openalex.org/W2147340222","https://openalex.org/W4235320685"],"related_works":["https://openalex.org/W2074099247","https://openalex.org/W4307862669","https://openalex.org/W4283069631","https://openalex.org/W2059330769","https://openalex.org/W6983084133","https://openalex.org/W2054779813","https://openalex.org/W4306729890","https://openalex.org/W2140833791","https://openalex.org/W4384153562","https://openalex.org/W4210786053"],"abstract_inverted_index":{"Neurodegenerative":[0,218],"diseases,":[1,16],"including":[2],"Alzheimer\u2019s":[3],"disease":[4,85,105],"(AD),":[5],"Parkinson\u2019s":[6,83],"disease,":[7,13],"amyotrophic":[8,124],"lateral":[9,125],"sclerosis":[10],"and":[11,103,131,256,273,284,297,307],"Huntington\u2019s":[12],"are":[14,71,181],"devastating":[15],"with":[17,75,117],"huge":[18,151],"unmet":[19],"medical":[20],"needs.":[21],"Although":[22],"it":[23],"has":[24,31,48,108],"been":[25,49,110],"estimated":[26],"that":[27,56,153,247],"the":[28,44,94,100,118,141,150,174,184,188,207,227,280,313],"pharmaceutical":[29,142,274],"industry":[30,143],"already":[32,163,299],"spent":[33],"billions":[34],"of":[35,60,89,96,121,134,187,199,239,282,316],"US":[36,204,240],"dollars":[37],"on":[38,231],"developing":[39],"a":[40,154,197],"treatment":[41],"for":[42,123,287,311],"AD,":[43],"output":[45],"so":[46],"far":[47],"dismal.":[50],"We,":[51],"like":[52],"many":[53],"others,":[54],"hope":[55],"this":[57,147,167],"long":[58,129],"history":[59],"failures":[61],"will":[62,234,251],"soon":[63],"be":[64],"replaced":[65],"by":[66,140],"success.":[67],"Whilst":[68],"symptomatic":[69],"treatments":[70,156],"valuable,":[72],"especially":[73],"those":[74],"clearly":[76],"observable":[77],"functional":[78],"outcomes":[79],"(e.g.,":[80],"l-DOPA":[81],"in":[82,87,112,146,196,212,223,254,295],"disease),":[84],"modification":[86],"terms":[88],"halting,":[90],"slowing":[91],"or":[92],"preventing":[93],"evolution":[95],"neurodegenerative":[97,114],"disorders":[98],"remains":[99],"Holy":[101],"Grail":[102],"no":[104],"modifier":[106],"product":[107],"yet":[109],"approved":[111],"any":[113],"disorder":[115],"\u2013":[116],"possible":[119],"exception":[120],"riluzole":[122],"sclerosis.":[126],"High":[127],"cost,":[128],"timelines":[130],"low":[132],"probability":[133],"success":[135],"have":[136,162,170],"led":[137],"to":[138,144,165,172,277,303],"reluctance":[139],"invest":[145],"area,":[148],"despite":[149],"rewards":[152],"successful":[155],"would":[157],"reap":[158],"[1].":[159],"Some":[160],"companies":[161,275],"opted":[164],"leave":[166],"area;":[168],"others":[169],"decided":[171],"\u2018reef":[173],"sail\u2019.":[175],"In":[176,225],"contrast,":[177],"publically":[178],"funded":[179],"efforts":[180],"growing.":[182],"During":[183],"first":[185,216],"decade":[186],"21st":[189],"century,":[190],"AD":[191,209,232],"national":[192],"plans":[193],"were":[194],"launched":[195,222,294],"variety":[198],"different":[200],"European":[201,271],"countries.":[202],"The":[203,215,260,289],"President":[205],"signed":[206],"National":[208],"Project":[210],"Act":[211],"January":[213],"2011.":[214],"European-wide":[217],"Disease":[219],"Research":[220],"was":[221,293],"2012.":[224],"2013":[226],"NIH":[228],"total":[229],"expenditure":[230],"research":[233],"reach":[235],"an":[236],"all-time":[237],"high":[238],"$529":[241],"million.":[242],"A":[243],"common":[244],"belief":[245],"is":[246,298],"public\u2013private":[248],"partnerships":[249],"(PPPs)":[250],"generate":[252],"breakthroughs":[253],"preclinical":[255,306],"clinical":[257,308],"areas":[258],"[2].":[259],"Innovative":[261],"Medicine":[262],"Initiative":[263],"(IMI)":[264],"represents":[265],"one":[266],"such":[267],"collaboration,":[268],"which":[269],"joins":[270],"governments":[272],"together":[276],"speed":[278],"up":[279],"development":[281],"better":[283],"safer":[285],"medicines":[286],"patients.":[288],"IMI":[290],"PharmaCog":[291],"project":[292],"2010":[296],"reporting":[300],"data":[301],"related":[302],"improved":[304],"early":[305],"experimental":[309],"designs":[310],"predicting":[312],"cognitive":[314],"properties":[315],"new":[317],"drug":[318],"candidates":[319],"[101].":[320]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}