{"id":"https://openalex.org/W2000059965","doi":"https://doi.org/10.1126/scisignal.2002858","title":"Pseudogenes: Newly Discovered Players in Human Cancer","display_name":"Pseudogenes: Newly Discovered Players in Human Cancer","publication_year":2012,"publication_date":"2012-09-18","ids":{"openalex":"https://openalex.org/W2000059965","doi":"https://doi.org/10.1126/scisignal.2002858","mag":"2000059965","pmid":"https://pubmed.ncbi.nlm.nih.gov/22990117"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.2002858","doi":"https://doi.org/10.1126/scisignal.2002858","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2002858","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017664557","display_name":"Laura Poliseno","orcid":"https://orcid.org/0000-0001-6557-955X","observed_orcids":["https://orcid.org/0000-0001-6557-955X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura Poliseno","raw_affiliation_strings":["Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (CRL-ITT), c/o IFC-CNR Via Moruzzi 1, 56124 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (CRL-ITT), c/o IFC-CNR Via Moruzzi 1, 56124 Pisa, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017664557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1678,"has_fulltext":false,"cited_by_count":174,"citation_normalized_percentile":{"value":0.78194888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"5","issue":"242","first_page":"re5","last_page":"re5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.10170000046491623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudogenes","display_name":"pseudogenes","score":1.0},{"id":"https://openalex.org/keywords/human-tumors","display_name":"human cancer","score":0.7760000228881836},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.9948523640632629},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7850791811943054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6874215602874756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6287611722946167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5068789124488831},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.49657994508743286},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.42035698890686035},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.41867369413375854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37911099195480347},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35468733310699463},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.06704851984977722},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011544","descriptor_name":"Pseudogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/scisignal.2002858","doi":"https://doi.org/10.1126/scisignal.2002858","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2002858","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:22990117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22990117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":176,"referenced_works":["https://openalex.org/W170732872","https://openalex.org/W301816106","https://openalex.org/W1235517956","https://openalex.org/W1545893705","https://openalex.org/W1547676465","https://openalex.org/W1597279890","https://openalex.org/W1840795163","https://openalex.org/W1933951165","https://openalex.org/W1941282326","https://openalex.org/W1943633942","https://openalex.org/W1964264557","https://openalex.org/W1964955815","https://openalex.org/W1966498224","https://openalex.org/W1967495544","https://openalex.org/W1968706078","https://openalex.org/W1969865366","https://openalex.org/W1970195561","https://openalex.org/W1971623350","https://openalex.org/W1972600524","https://openalex.org/W1972730151","https://openalex.org/W1973284955","https://openalex.org/W1974134624","https://openalex.org/W1976149758","https://openalex.org/W1976658794","https://openalex.org/W1977803417","https://openalex.org/W1979662111","https://openalex.org/W1979747601","https://openalex.org/W1982349215","https://openalex.org/W1985515979","https://openalex.org/W1986202693","https://openalex.org/W1986365556","https://openalex.org/W1986576295","https://openalex.org/W1988459773","https://openalex.org/W1989904037","https://openalex.org/W1989981053","https://openalex.org/W1991282594","https://openalex.org/W1993786478","https://openalex.org/W1996122202","https://openalex.org/W1997379339","https://openalex.org/W1997509288","https://openalex.org/W1998557820","https://openalex.org/W1999286199","https://openalex.org/W2003343781","https://openalex.org/W2003432188","https://openalex.org/W2006190082","https://openalex.org/W2006195332","https://openalex.org/W2006556963","https://openalex.org/W2007564153","https://openalex.org/W2007702198","https://openalex.org/W2010461414","https://openalex.org/W2011372427","https://openalex.org/W2013304617","https://openalex.org/W2015175027","https://openalex.org/W2017635408","https://openalex.org/W2017768662","https://openalex.org/W2020483546","https://openalex.org/W2021747556","https://openalex.org/W2022017077","https://openalex.org/W2022863488","https://openalex.org/W2022985713","https://openalex.org/W2023497766","https://openalex.org/W2024628274","https://openalex.org/W2026762779","https://openalex.org/W2027162391","https://openalex.org/W2027223938","https://openalex.org/W2028837633","https://openalex.org/W2030205108","https://openalex.org/W2031176852","https://openalex.org/W2032991514","https://openalex.org/W2033156554","https://openalex.org/W2033405874","https://openalex.org/W2034771967","https://openalex.org/W2034910725","https://openalex.org/W2035820016","https://openalex.org/W2037368980","https://openalex.org/W2038197188","https://openalex.org/W2039556582","https://openalex.org/W2040058302","https://openalex.org/W2044393771","https://openalex.org/W2044601473","https://openalex.org/W2045736181","https://openalex.org/W2046222751","https://openalex.org/W2046387002","https://openalex.org/W2046580688","https://openalex.org/W2047351364","https://openalex.org/W2047827091","https://openalex.org/W2049668866","https://openalex.org/W2050542454","https://openalex.org/W2054000192","https://openalex.org/W2055821541","https://openalex.org/W2056992430","https://openalex.org/W2059794606","https://openalex.org/W2061427860","https://openalex.org/W2063955247","https://openalex.org/W2064419397","https://openalex.org/W2065189819","https://openalex.org/W2065864502","https://openalex.org/W2065904094","https://openalex.org/W2066659223","https://openalex.org/W2067711920","https://openalex.org/W2067806955","https://openalex.org/W2067988300","https://openalex.org/W2068773764","https://openalex.org/W2069799979","https://openalex.org/W2070777085","https://openalex.org/W2071271349","https://openalex.org/W2075019518","https://openalex.org/W2077475358","https://openalex.org/W2078898570","https://openalex.org/W2080067787","https://openalex.org/W2082017108","https://openalex.org/W2082989859","https://openalex.org/W2085734338","https://openalex.org/W2087272148","https://openalex.org/W2089050448","https://openalex.org/W2090545754","https://openalex.org/W2090814663","https://openalex.org/W2093466316","https://openalex.org/W2093691792","https://openalex.org/W2093956979","https://openalex.org/W2094028041","https://openalex.org/W2094454538","https://openalex.org/W2094763416","https://openalex.org/W2096097986","https://openalex.org/W2096560037","https://openalex.org/W2097384100","https://openalex.org/W2098352755","https://openalex.org/W2099780734","https://openalex.org/W2101243784","https://openalex.org/W2102304447","https://openalex.org/W2103485746","https://openalex.org/W2105333044","https://openalex.org/W2105702722","https://openalex.org/W2109968848","https://openalex.org/W2111466507","https://openalex.org/W2112554075","https://openalex.org/W2112953993","https://openalex.org/W2117204942","https://openalex.org/W2119874027","https://openalex.org/W2120909288","https://openalex.org/W2122083992","https://openalex.org/W2126302009","https://openalex.org/W2128034264","https://openalex.org/W2130021519","https://openalex.org/W2130022567","https://openalex.org/W2132283613","https://openalex.org/W2133066292","https://openalex.org/W2135398049","https://openalex.org/W2136630287","https://openalex.org/W2138008048","https://openalex.org/W2138544523","https://openalex.org/W2139477237","https://openalex.org/W2141828080","https://openalex.org/W2142124206","https://openalex.org/W2142144785","https://openalex.org/W2143513578","https://openalex.org/W2145931730","https://openalex.org/W2148923432","https://openalex.org/W2148929244","https://openalex.org/W2150296976","https://openalex.org/W2151548807","https://openalex.org/W2156052197","https://openalex.org/W2157241157","https://openalex.org/W2158898661","https://openalex.org/W2159801541","https://openalex.org/W2159907132","https://openalex.org/W2162085813","https://openalex.org/W2162116663","https://openalex.org/W2162558393","https://openalex.org/W2162641485","https://openalex.org/W2162681307","https://openalex.org/W2164207455","https://openalex.org/W2169857330","https://openalex.org/W2170952313","https://openalex.org/W2404777568","https://openalex.org/W6948519597"],"related_works":["https://openalex.org/W2335889055","https://openalex.org/W2141221830","https://openalex.org/W2887722210","https://openalex.org/W7095649902","https://openalex.org/W2111466507","https://openalex.org/W4231197169","https://openalex.org/W3031622896","https://openalex.org/W4385654830","https://openalex.org/W327380490","https://openalex.org/W57448083"],"abstract_inverted_index":{"Because":[0],"they":[1],"are":[2],"generally":[3],"noncoding":[4],"and":[5,9,44],"thus":[6],"considered":[7],"nonfunctional":[8],"unimportant,":[10],"pseudogenes":[11,60],"have":[12,18,40,61],"long":[13],"been":[14],"neglected.":[15],"Recent":[16],"advances":[17],"established":[19],"that":[20,45],"the":[21,26,33,79],"DNA":[22],"of":[23,68,71,81],"a":[24,30,37,64,75],"pseudogene,":[25,31],"RNA":[27],"transcribed":[28],"from":[29,36],"or":[32],"protein":[34],"translated":[35],"pseudogene":[38],"can":[39,48],"multiple,":[41],"diverse":[42],"functions":[43,47],"these":[46],"affect":[49],"not":[50],"only":[51],"their":[52],"parental":[53],"genes":[54],"but":[55],"also":[56],"unrelated":[57],"genes.":[58],"Therefore,":[59],"emerged":[62],"as":[63],"previously":[65],"unappreciated":[66],"class":[67],"sophisticated":[69],"modulators":[70],"gene":[72],"expression,":[73],"with":[74],"multifaceted":[76],"involvement":[77],"in":[78],"pathogenesis":[80],"human":[82],"cancer.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}