{"id":"https://openalex.org/W2000054877","doi":"https://doi.org/10.1038/clpt.1988.55","title":"Age-associated stereoselective alterations in hexobarbital metabolism","display_name":"Age-associated stereoselective alterations in hexobarbital metabolism","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W2000054877","doi":"https://doi.org/10.1038/clpt.1988.55","mag":"2000054877","pmid":"https://pubmed.ncbi.nlm.nih.gov/3356087"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.1988.55","doi":"https://doi.org/10.1038/clpt.1988.55","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1988.55","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111746291","display_name":"Mary H.H. Chandler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary H H Chandler","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky College of Pharmacy, Lexington 40536-0082","Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky College of Pharmacy, Lexington 40536-0082","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089383511","display_name":"Samuel R Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel R Scott","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110537749","display_name":"Robert A. Blouin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A Blouin","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky College of Pharmacy and the University of Kentucky Medical","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110537749"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":5.5949,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96939954,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"43","issue":"4","first_page":"436","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexobarbital","display_name":"hexobarbital","score":0.9829999804496765},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.7120000123977661},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.7149999737739563},{"id":"https://openalex.org/keywords/oral-clearance","display_name":"oral clearance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.4830000102519989},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/racemic-drugs","display_name":"racemic drugs","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2777466164","wikidata":"https://www.wikidata.org/wiki/Q421183","display_name":"Hexobarbital","level":4,"score":0.9894689321517944},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.6361069679260254},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.6128904223442078},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5474444627761841},{"id":"https://openalex.org/C38022665","wikidata":"https://www.wikidata.org/wiki/Q1149305","display_name":"Disposition","level":2,"score":0.5418764352798462},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5365379452705383},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5317351222038269},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.4836534261703491},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.480969101190567},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.47299250960350037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46914616227149963},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.43194615840911865},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43137505650520325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37682199478149414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36651667952537537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3634181022644043},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24502310156822205},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1631370484828949},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10641655325889587},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.09897559881210327},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.06871241331100464},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006591","descriptor_name":"Hexobarbital","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/clpt.1988.55","doi":"https://doi.org/10.1038/clpt.1988.55","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1988.55","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:3356087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3356087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038132771","https://openalex.org/W2004038693","https://openalex.org/W1537460470","https://openalex.org/W2262017290","https://openalex.org/W1735321013","https://openalex.org/W2073356537","https://openalex.org/W2044001690","https://openalex.org/W2103772387","https://openalex.org/W1966640282","https://openalex.org/W2346493907"],"abstract_inverted_index":{"This":[0,102],"clinical":[1],"investigation":[2],"was":[3,26,78,145],"designed":[4],"to":[5],"study":[6],"the":[7,61,83,87,113,118,148],"influence":[8],"of":[9,23,42,152,159],"age":[10],"on":[11],"stereoselective":[12],"drug":[13,172],"disposition":[14,22],"using":[15],"hexobarbital":[16,24,143],"as":[17],"a":[18,105],"model":[19],"marker.":[20],"The":[21],"enantiomers":[25],"investigated":[27],"in":[28,82,86,104,112,139,157,173],"10":[29,32],"young":[30,62,84,114],"and":[31,63],"elderly,":[33],"healthy":[34],"male":[35],"volunteers.":[36],"Mean":[37],"oral":[38,74,109],"clearance":[39,75,110],"(+/-":[40,76],"SD)":[41,77],"d-hexobarbital":[43],"(1.9":[44],"+/-":[45,49,91,95,122,126],"0.5":[46],"vs.":[47,93,124],"1.7":[48],"0.3":[50],"ml/min/kg;":[51,97],"P":[52,98,128],"greater":[53,81,107,136],"than":[54,85,100,130,137],"0.05)":[55,138],"did":[56],"not":[57,165],"differ":[58],"significantly":[59,106],"between":[60,147],"elderly":[64,88,119],"subjects,":[65],"respectively.":[66],"However,":[67],"despite":[68],"wide":[69],"intersubject":[70],"variability,":[71],"l-hexobarbital":[72],"mean":[73],"approximately":[79],"twofold":[80],"subjects":[89,120],"(16.9":[90],"11.9":[92],"8.2":[94],"3.2":[96],"less":[99,129],"0.05).":[101],"resulted":[103],"enantiomeric":[108],"ratio":[111],"when":[115],"compared":[116],"with":[117],"(8.3":[121],"3.4":[123],"4.7":[125],"1.4;":[127],"0.01).":[131],"No":[132],"significant":[133],"difference":[134],"(P":[135],"pharmacologic":[140],"response":[141],"after":[142],"administration":[144],"found":[146],"two":[149],"groups.":[150],"Demonstration":[151],"an":[153],"age-related":[154],"preferential":[155],"decline":[156],"metabolism":[158],"one":[160],"enantiomer":[161],"over":[162],"another":[163],"has":[164],"been":[166],"reported":[167],"previously":[168],"for":[169],"any":[170],"racemic":[171],"animals":[174],"or":[175],"humans.":[176]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
