{"id":"https://openalex.org/W2000017815","doi":"https://doi.org/10.3390/ijms150711637","title":"Supraspliceosomes at Defined Functional States Portray the Pre-Assembled Nature of the Pre-mRNA Processing Machine in the Cell Nucleus","display_name":"Supraspliceosomes at Defined Functional States Portray the Pre-Assembled Nature of the Pre-mRNA Processing Machine in the Cell Nucleus","publication_year":2014,"publication_date":"2014-06-30","ids":{"openalex":"https://openalex.org/W2000017815","doi":"https://doi.org/10.3390/ijms150711637","mag":"2000017815","pmid":"https://pubmed.ncbi.nlm.nih.gov/24983480","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4139805"},"language":"en","primary_location":{"id":"doi:10.3390/ijms150711637","doi":"https://doi.org/10.3390/ijms150711637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms150711637","pdf_url":"https://www.mdpi.com/1422-0067/15/7/11637/pdf?version=1404135831","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/15/7/11637/pdf?version=1404135831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010134772","display_name":"Hani Kotzer-Nevo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hani Kotzer-Nevo","raw_affiliation_strings":["Department of Genetics, the Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, the Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110208764","display_name":"Fl\u00e1via de Lima Alves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134627","display_name":"Wellcome Centre for Cell Biology","ror":"https://ror.org/03xbccz06","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210134627","https://openalex.org/I87048295","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Flavia De Lima Alves","raw_affiliation_strings":["Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK","institution_ids":["https://openalex.org/I4210134627","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076844877","display_name":"Juri Rappsilber","orcid":"https://orcid.org/0000-0001-5999-1310","observed_orcids":["https://orcid.org/0000-0001-5999-1310"]},"institutions":[{"id":"https://openalex.org/I4210134627","display_name":"Wellcome Centre for Cell Biology","ror":"https://ror.org/03xbccz06","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210134627","https://openalex.org/I87048295","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Juri Rappsilber","raw_affiliation_strings":["Institute of Bioanalytics, Department of Biochemistry, Technische Universit\u00e4t Berlin,  Berlin 13353, Germany","Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioanalytics, Department of Biochemistry, Technische Universit\u00e4t Berlin,  Berlin 13353, Germany","institution_ids":["https://openalex.org/I4577782"]},{"raw_affiliation_string":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK","institution_ids":["https://openalex.org/I4210134627","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047459030","display_name":"Joseph M. Sperling","orcid":"https://orcid.org/0000-0003-1916-5633","observed_orcids":["https://orcid.org/0000-0003-1916-5633"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Joseph Sperling","raw_affiliation_strings":["Department of Organic Chemistry, the Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, the Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045761416","display_name":"Ruth Sperling","orcid":"https://orcid.org/0000-0002-8950-4584","observed_orcids":["https://orcid.org/0000-0002-8950-4584"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ruth Sperling","raw_affiliation_strings":["Department of Genetics, the Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, the Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045761416"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.755,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.66742781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"7","first_page":"11637","last_page":"11664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spliceosome-assembly","display_name":"spliceosome assembly","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.9700000286102295},{"id":"https://openalex.org/keywords/u-snrnps","display_name":"U snRNPs","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pre-mrna-processing","display_name":"pre-mRNA processing","score":0.5759999752044678},{"id":"https://openalex.org/keywords/affinity-purification","display_name":"affinity purification","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C68483431","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"snRNP","level":5,"score":0.9463948011398315},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.9262736439704895},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.9186620712280273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7070326805114746},{"id":"https://openalex.org/C102063271","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Precursor mRNA","level":5,"score":0.6643674373626709},{"id":"https://openalex.org/C100299639","wikidata":"https://www.wikidata.org/wiki/Q284578","display_name":"Small nuclear RNA","level":5,"score":0.6163584589958191},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.6000061631202698},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5573757290840149},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5528402924537659},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5277270078659058},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.5191887617111206},{"id":"https://openalex.org/C2908584439","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"Small nuclear ribonucleoprotein","level":5,"score":0.4980344772338867},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.494142085313797},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43164291977882385},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.42020827531814575},{"id":"https://openalex.org/C69551769","wikidata":"https://www.wikidata.org/wiki/Q899401","display_name":"Protein splicing","level":5,"score":0.41577330231666565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36794447898864746},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3327375650405884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15081796050071716},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.0878450870513916},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017381","descriptor_name":"Spliceosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017411","descriptor_name":"Ribonucleoproteins, Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017909","descriptor_name":"Levivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/ijms150711637","doi":"https://doi.org/10.3390/ijms150711637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms150711637","pdf_url":"https://www.mdpi.com/1422-0067/15/7/11637/pdf?version=1404135831","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3108036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4139805","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4139805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4139805","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:24983480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24983480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.658.4992","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.658.4992","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1422-0067/15/7/11637/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b37d8303799d46d1911bc5fc6a94d6f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b37d8303799d46d1911bc5fc6a94d6f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 11637-11664 (2014)","raw_type":"article"},{"id":"pmh:oai:pure.ed.ac.uk:publications/c78e54de-ac11-40a4-abe8-30db78b93654","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/portal/en/publications/supraspliceosomes-at-defined-functional-states-portray-the-preassembled-nature-of-the-premrna-processing-machine-in-the-cell-nucleus(c78e54de-ac11-40a4-abe8-30db78b93654).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kotzer-Nevo, H, de Lima Alves, F, Rappsilber, J, Sperling, J & Sperling, R 2014, 'Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus', International Journal of Molecular Sciences, vol. 15, no. 7, pp. 11637-11664. https://doi.org/10.3390/ijms150711637","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3390/ijms150711637","doi":"https://doi.org/10.3390/ijms150711637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms150711637","pdf_url":"https://www.mdpi.com/1422-0067/15/7/11637/pdf?version=1404135831","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1438226677","display_name":"Protein structures in the context of time and space by mass spectrometry.","funder_award_id":"103139","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5084572106","display_name":"The Mammalian Cellular Splicing Machine - Structure and Function","funder_award_id":"R01GM079549","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5390606315","display_name":"Protein structures in the context of time and space by mass spectrometry.","funder_award_id":"103139/Z/13/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5518097576","display_name":"Three-dimensional proteomics: Mapping the geometry of large protein assemblies using cross-linking, mass spectrometry, and bioinformatics.","funder_award_id":"084229","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5940583438","display_name":"Core funding renewal for the Wellcome Trust Centre for Cell Biology .","funder_award_id":"092076","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000017815.pdf","grobid_xml":"https://content.openalex.org/works/W2000017815.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W46722564","https://openalex.org/W69868065","https://openalex.org/W569835445","https://openalex.org/W594930176","https://openalex.org/W1970302143","https://openalex.org/W1972801928","https://openalex.org/W1985880320","https://openalex.org/W1992274603","https://openalex.org/W1997381798","https://openalex.org/W2003236418","https://openalex.org/W2011281057","https://openalex.org/W2016093990","https://openalex.org/W2026657651","https://openalex.org/W2029425286","https://openalex.org/W2031061513","https://openalex.org/W2037726485","https://openalex.org/W2038182020","https://openalex.org/W2038424676","https://openalex.org/W2040023740","https://openalex.org/W2041519101","https://openalex.org/W2041562931","https://openalex.org/W2042477053","https://openalex.org/W2050858058","https://openalex.org/W2051015514","https://openalex.org/W2052498125","https://openalex.org/W2057068701","https://openalex.org/W2061434726","https://openalex.org/W2063692299","https://openalex.org/W2068264401","https://openalex.org/W2070030376","https://openalex.org/W2075365477","https://openalex.org/W2076358214","https://openalex.org/W2078594804","https://openalex.org/W2083260388","https://openalex.org/W2092801170","https://openalex.org/W2093828809","https://openalex.org/W2095692832","https://openalex.org/W2096575861","https://openalex.org/W2104063911","https://openalex.org/W2107731897","https://openalex.org/W2108978314","https://openalex.org/W2117506397","https://openalex.org/W2123203780","https://openalex.org/W2123289678","https://openalex.org/W2126414543","https://openalex.org/W2129550649","https://openalex.org/W2131824470","https://openalex.org/W2132505931","https://openalex.org/W2143350291","https://openalex.org/W2146008294","https://openalex.org/W2153165650","https://openalex.org/W2155103924","https://openalex.org/W2162079209","https://openalex.org/W2166437079","https://openalex.org/W3128079552","https://openalex.org/W3215839487"],"related_works":["https://openalex.org/W7097169600","https://openalex.org/W2119553819","https://openalex.org/W2316311476","https://openalex.org/W2126414543","https://openalex.org/W1972801928","https://openalex.org/W2605631608","https://openalex.org/W1987403693","https://openalex.org/W2068264401","https://openalex.org/W2076794781","https://openalex.org/W4247989443"],"abstract_inverted_index":{"When":[0],"isolated":[1,54],"from":[2],"mammalian":[3],"cell":[4],"nuclei,":[5],"all":[6,26,138,143],"nuclear":[7,50],"pre-mRNAs":[8,51],"are":[9,37,119,135],"packaged":[10],"in":[11,39,79,121,152,164,174],"multi-subunit":[12],"large":[13],"ribonucleoprotein":[14],"complexes-supraspliceosomes-composed":[15],"of":[16,49,58,129,155,178,194,199],"four":[17],"native":[18,189],"spliceosomes":[19],"interconnected":[20],"by":[21],"the":[22,46,59,126,167,179,192,200],"pre-mRNA.":[23],"Supraspliceosomes":[24,41],"contain":[25],"five":[27,139],"spliceosomal":[28],"U":[29,140,156,160,175],"snRNPs,":[30],"together":[31],"with":[32,137],"other":[33],"splicing":[34,60,65,76,107,144,168,193],"factors,":[35],"and":[36,91,159,197],"functional":[38,89],"splicing.":[40],"studied":[42],"thus":[43],"far":[44],"represent":[45],"steady-state":[47],"population":[48,128],"that":[52,103,149,162],"were":[53],"at":[55,87,142],"different":[56],"stages":[57],"reaction.":[61],"To":[62],"analyze":[63],"specific":[64,88],"complexes,":[66],"here,":[67],"we":[68,101],"affinity":[69,105],"purified":[70,106],"Pseudomonas":[71],"aeruginosa":[72],"phage":[73],"7":[74],"(PP7)-tagged":[75],"complexes":[77,108],"assembled":[78,109,120,136],"vivo":[80,165],"on":[81,110,115],"Adenovirus":[82],"Major":[83],"Late":[84],"(AdML)":[85],"transcripts":[86],"stages,":[90],"characterized":[92],"them":[93],"using":[94],"molecular":[95],"techniques":[96],"including":[97],"mass":[98],"spectrometry.":[99],"First,":[100],"show":[102],"these":[104,131],"PP7-tagged":[111,116],"AdML":[112,117],"mRNA":[113],"or":[114],"pre-mRNA":[118],"supraspliceosomes.":[122],"Second,":[123],"similar":[124],"to":[125,186],"general":[127],"supraspliceosomes,":[130],"defined":[132],"supraspliceosomes":[133],"populations":[134],"snRNPs":[141],"stages.":[145],"This":[146],"study":[147],"shows":[148],"dynamic":[150],"changes":[151,173],"base-pairing":[153],"interactions":[154,201],"snRNA:U":[157],"snRNA":[158],"snRNA:pre-mRNA":[161],"occur":[163],"during":[166],"reaction":[169],"do":[170],"not":[171],"require":[172],"snRNP":[176],"composition":[177],"supraspliceosome.":[180],"Furthermore,":[181],"there":[182],"is":[183],"no":[184],"need":[185],"reassemble":[187],"a":[188],"spliceosome":[190],"for":[191],"each":[195],"intron,":[196],"rearrangements":[198],"will":[202],"suffice.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
