{"id":"https://openalex.org/W2000008802","doi":"https://doi.org/10.1007/s00439-014-1524-3","title":"A systematic heritability analysis of the human whole blood transcriptome","display_name":"A systematic heritability analysis of the human whole blood transcriptome","publication_year":2015,"publication_date":"2015-01-13","ids":{"openalex":"https://openalex.org/W2000008802","doi":"https://doi.org/10.1007/s00439-014-1524-3","mag":"2000008802","pmid":"https://pubmed.ncbi.nlm.nih.gov/25585846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4339826"},"language":"en","primary_location":{"id":"doi:10.1007/s00439-014-1524-3","doi":"https://doi.org/10.1007/s00439-014-1524-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00439-014-1524-3","pdf_url":null,"source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4339826","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005940300","display_name":"Tianxiao Huan","orcid":"https://orcid.org/0000-0001-5840-9413","observed_orcids":["https://orcid.org/0000-0001-5840-9413"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianxiao Huan","raw_affiliation_strings":["Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA, huant@mail.nih.gov","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA, huant@mail.nih.gov","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343311","display_name":"Chunyu Liu","orcid":"https://orcid.org/0000-0002-9160-0153","observed_orcids":["https://orcid.org/0000-0002-9160-0153","https://orcid.org/0000-0002-6732-3758","https://orcid.org/0000-0002-2652-5409"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunyu Liu","raw_affiliation_strings":["Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051097194","display_name":"Roby Joehanes","orcid":"https://orcid.org/0000-0001-5549-9054","observed_orcids":["https://orcid.org/0000-0001-5549-9054"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I29955533","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I29955533"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roby Joehanes","raw_affiliation_strings":["Division of Computational Bioscience, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA","Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","Harvard Medical School, Boston, MA, USA","Hebrew SeniorLife, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Bioscience, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I29955533"]},{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hebrew SeniorLife, Boston, MA, USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052194166","display_name":"Xiaoling Zhang","orcid":"https://orcid.org/0000-0001-8237-1857","observed_orcids":["https://orcid.org/0000-0001-8237-1857"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoling Zhang","raw_affiliation_strings":["Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032791624","display_name":"Brian H. Chen","orcid":"https://orcid.org/0000-0001-9065-3301","observed_orcids":["https://orcid.org/0000-0001-9065-3301"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian H. Chen","raw_affiliation_strings":["Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059921628","display_name":"Andrew D. Johnson","orcid":"https://orcid.org/0000-0001-6369-5178","observed_orcids":["https://orcid.org/0000-0001-6369-5178"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Johnson","raw_affiliation_strings":["Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063008438","display_name":"Chen Yao","orcid":"https://orcid.org/0000-0002-3944-7788","observed_orcids":["https://orcid.org/0000-0002-3944-7788"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Yao","raw_affiliation_strings":["Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068991885","display_name":"Paul L. Courchesne","orcid":"https://orcid.org/0000-0001-5691-6913","observed_orcids":["https://orcid.org/0000-0001-5691-6913"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Courchesne","raw_affiliation_strings":["Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084614356","display_name":"Christopher J. O\u2019Donnell","orcid":"https://orcid.org/0000-0002-2667-8624","observed_orcids":["https://orcid.org/0000-0002-2667-8624"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. O\u2019Donnell","raw_affiliation_strings":["Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023243366","display_name":"Peter J. Munson","orcid":"https://orcid.org/0000-0003-0824-7887","observed_orcids":["https://orcid.org/0000-0003-0824-7887"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I29955533","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I29955533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Munson","raw_affiliation_strings":["Division of Computational Bioscience, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Bioscience, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I29955533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074117194","display_name":"Daniel A Levy","orcid":"https://orcid.org/0000-0003-1843-8724","observed_orcids":["https://orcid.org/0000-0003-1843-8724"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel Levy","raw_affiliation_strings":["Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4388891757"]},{"raw_affiliation_string":"Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA","institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074117194"],"corresponding_institution_ids":["https://openalex.org/I4210106489","https://openalex.org/I4210123017","https://openalex.org/I4388891757"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":2.2826,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88081917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"134","issue":"3","first_page":"343","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heritability-of-gene-expression","display_name":"heritability of gene expression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/whole-blood-transcriptome","display_name":"whole blood transcriptome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cis-eqtl","display_name":"cis-eQTL","score":0.9440000057220459},{"id":"https://openalex.org/keywords/trans-eqtl","display_name":"trans-eQTL","score":1.0},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9459999799728394},{"id":"https://openalex.org/keywords/16p11-2","display_name":"16p11.2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sult1a1","display_name":"SULT1A1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tufm","display_name":"TUFM","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.41100001335144043},{"id":"https://openalex.org/keywords/framingham-heart-study","display_name":"Framingham Heart Study","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.8929548859596252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8185149431228638},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.8043075799942017},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7663894295692444},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7563663721084595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7015202045440674},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6365830302238464},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5477955341339111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5009150505065918},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48796218633651733},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.44719600677490234},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.4205129146575928},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2716981768608093},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20731908082962036},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14311286807060242},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.1244954764842987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.052498817443847656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.048922985792160034}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00439-014-1524-3","doi":"https://doi.org/10.1007/s00439-014-1524-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00439-014-1524-3","pdf_url":null,"source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},{"id":"pmid:25585846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25585846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4339826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4339826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hum Genet","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4339826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4339826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hum Genet","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G416610142","display_name":"Framingham Project/Levy","funder_award_id":"Z01HL006001","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000885269","display_name":"Framingham Project/Levy","funder_award_id":"ZIAHL006001","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1524548598","https://openalex.org/W1966682269","https://openalex.org/W1976844911","https://openalex.org/W1984939442","https://openalex.org/W1985515653","https://openalex.org/W1992088789","https://openalex.org/W2000081470","https://openalex.org/W2001629081","https://openalex.org/W2019232525","https://openalex.org/W2040924786","https://openalex.org/W2040964350","https://openalex.org/W2041155293","https://openalex.org/W2043842514","https://openalex.org/W2045017910","https://openalex.org/W2053452740","https://openalex.org/W2059742736","https://openalex.org/W2090808827","https://openalex.org/W2091576663","https://openalex.org/W2101605059","https://openalex.org/W2110065044","https://openalex.org/W2112087830","https://openalex.org/W2112848098","https://openalex.org/W2115335486","https://openalex.org/W2115801316","https://openalex.org/W2116404829","https://openalex.org/W2117446594","https://openalex.org/W2121812921","https://openalex.org/W2122713183","https://openalex.org/W2124655419","https://openalex.org/W2129254992","https://openalex.org/W2135199713","https://openalex.org/W2135895196","https://openalex.org/W2141642891","https://openalex.org/W2145090915","https://openalex.org/W2147311167","https://openalex.org/W2154998360","https://openalex.org/W2163013660","https://openalex.org/W2166501262","https://openalex.org/W2166776142","https://openalex.org/W2169785917","https://openalex.org/W2338802886","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W2567827323","https://openalex.org/W1779614964","https://openalex.org/W2052628795","https://openalex.org/W2048868021","https://openalex.org/W1973845055","https://openalex.org/W3197364483","https://openalex.org/W2549306510","https://openalex.org/W2085126855","https://openalex.org/W1989167060","https://openalex.org/W2976098430"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}