{"id":"https://openalex.org/W2000005359","doi":"https://doi.org/10.1073/pnas.1400450111","title":"Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis","display_name":"Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis","publication_year":2014,"publication_date":"2014-02-05","ids":{"openalex":"https://openalex.org/W2000005359","doi":"https://doi.org/10.1073/pnas.1400450111","mag":"2000005359","pmid":"https://pubmed.ncbi.nlm.nih.gov/24501120"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1400450111","doi":"https://doi.org/10.1073/pnas.1400450111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1400450111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061293009","display_name":"Jon N Penterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Penterman","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035259692","display_name":"Ryan Abo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan P. Abo","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075657088","display_name":"Nicole J. De Nisco","orcid":"https://orcid.org/0000-0002-7670-5301","observed_orcids":["https://orcid.org/0000-0002-7670-5301"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole J. De Nisco","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010832397","display_name":"Markus F. F. Arnold","orcid":"https://orcid.org/0000-0002-1515-3582","observed_orcids":["https://orcid.org/0000-0002-1515-3582"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus F. F. Arnold","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010640622","display_name":"Renato Longhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109941","display_name":"Institute of Chemistry of Molecular Recognition","ror":"https://ror.org/0141vn777","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210109941","https://openalex.org/I4210155236","https://openalex.org/I4403928382"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Longhi","raw_affiliation_strings":["Consiglio Nazionale delle Ricerche\u2013Istituto di Chimica del Riconoscimento Molecolare, 20131 Milan, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consiglio Nazionale delle Ricerche\u2013Istituto di Chimica del Riconoscimento Molecolare, 20131 Milan, Italy; and","institution_ids":["https://openalex.org/I4210109941","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040102137","display_name":"Matteo Zanda","orcid":"https://orcid.org/0000-0002-8257-5232","observed_orcids":["https://orcid.org/0000-0002-8257-5232"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I4210109941","display_name":"Institute of Chemistry of Molecular Recognition","ror":"https://ror.org/0141vn777","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210109941","https://openalex.org/I4210155236","https://openalex.org/I4403928382"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Matteo Zanda","raw_affiliation_strings":["Consiglio Nazionale delle Ricerche\u2013Istituto di Chimica del Riconoscimento Molecolare, 20131 Milan, Italy; and","School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom","cSchool of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consiglio Nazionale delle Ricerche\u2013Istituto di Chimica del Riconoscimento Molecolare, 20131 Milan, Italy; and","institution_ids":["https://openalex.org/I4210109941","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"cSchool of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112719442","display_name":"Graham Charles Walker","orcid":"https://orcid.org/0000-0001-7243-8261","observed_orcids":["https://orcid.org/0000-0001-7243-8261"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham C. Walker","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"aDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.2466,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.99634608,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"111","issue":"9","first_page":"3561","last_page":"3566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11470","display_name":"Legume Nitrogen Fixing Symbiosis","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11470","display_name":"Legume Nitrogen Fixing Symbiosis","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinorhizobium-meliloti","display_name":"Sinorhizobium meliloti","score":1.0},{"id":"https://openalex.org/keywords/nodule-specific-cysteine-rich-peptides","display_name":"nodule-specific cysteine-rich peptides","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bacteroid-differentiation","display_name":"bacteroid differentiation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/endoreduplication","display_name":"endoreduplication","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-division-inhibition","display_name":"cell division inhibition","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ctra","display_name":"CtrA","score":0.7620000243186951},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.8299999833106995},{"id":"https://openalex.org/keywords/symbiosis","display_name":"symbiosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7170000076293945},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7229999899864197},{"id":"https://openalex.org/keywords/legume-rhizobium-symbiosis","display_name":"legume-rhizobium symbiosis","score":0.828000009059906},{"id":"https://openalex.org/keywords/host-pathogen-signaling","display_name":"host-pathogen signaling","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2777304268","wikidata":"https://www.wikidata.org/wiki/Q2696072","display_name":"Sinorhizobium meliloti","level":4,"score":0.8834837079048157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8202973008155823},{"id":"https://openalex.org/C43144210","wikidata":"https://www.wikidata.org/wiki/Q121610","display_name":"Symbiosis","level":3,"score":0.751671314239502},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5848026871681213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.569778561592102},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.49360454082489014},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4471130073070526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3748161792755127},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34659141302108765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31004956364631653},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24264264106750488}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007887","descriptor_name":"Fabaceae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016962","descriptor_name":"Sinorhizobium meliloti","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D053204","descriptor_name":"Root Nodules, Plant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1400450111","doi":"https://doi.org/10.1073/pnas.1400450111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1400450111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:24501120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24501120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3122242","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948309","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3948309","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948309","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3948309","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948309","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G115765347","display_name":null,"funder_award_id":"GM31010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G613990440","display_name":null,"funder_award_id":"P30ES002109","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7921590429","display_name":"Molecular Genetics of Rhizobium Nodulation Plasmids","funder_award_id":"R01GM031030","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891960","display_name":"Cancer Center Support (Core) Grant","funder_award_id":"P30CA014051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G941982536","display_name":null,"funder_award_id":"P30-CA-14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1497492892","https://openalex.org/W1542285910","https://openalex.org/W1563546096","https://openalex.org/W1852979501","https://openalex.org/W1963554693","https://openalex.org/W1971694877","https://openalex.org/W1979138345","https://openalex.org/W1979153989","https://openalex.org/W1980645074","https://openalex.org/W1982868413","https://openalex.org/W1994901531","https://openalex.org/W1998744918","https://openalex.org/W1999224877","https://openalex.org/W1999754734","https://openalex.org/W2006268628","https://openalex.org/W2016608967","https://openalex.org/W2028149603","https://openalex.org/W2035152331","https://openalex.org/W2038215655","https://openalex.org/W2039072473","https://openalex.org/W2039633096","https://openalex.org/W2057501974","https://openalex.org/W2058681460","https://openalex.org/W2062542418","https://openalex.org/W2065637677","https://openalex.org/W2069945629","https://openalex.org/W2070607600","https://openalex.org/W2073451711","https://openalex.org/W2074443244","https://openalex.org/W2078185668","https://openalex.org/W2080693057","https://openalex.org/W2084975317","https://openalex.org/W2091358620","https://openalex.org/W2096079692","https://openalex.org/W2097846684","https://openalex.org/W2100020625","https://openalex.org/W2101629802","https://openalex.org/W2102013978","https://openalex.org/W2104704368","https://openalex.org/W2111163989","https://openalex.org/W2115836628","https://openalex.org/W2118522962","https://openalex.org/W2121093284","https://openalex.org/W2132009717","https://openalex.org/W2132481315","https://openalex.org/W2143286186","https://openalex.org/W2143692321","https://openalex.org/W2150988437","https://openalex.org/W2157614298","https://openalex.org/W2164045264","https://openalex.org/W2169032295"],"related_works":["https://openalex.org/W2038948819","https://openalex.org/W1938321979","https://openalex.org/W2133191145","https://openalex.org/W1909024312","https://openalex.org/W4403384168","https://openalex.org/W2150988437","https://openalex.org/W47884232","https://openalex.org/W1497233449","https://openalex.org/W2521560206","https://openalex.org/W4297311555"],"abstract_inverted_index":{"The":[0],"\u03b1-proteobacterium":[1],"Sinorhizobium":[2],"meliloti":[3,21,72,206,235],"establishes":[4],"a":[5,79,101,216],"chronic":[6],"intracellular":[7,229],"infection":[8],"during":[9,211,239],"the":[10,37,84,92,117,126,139],"symbiosis":[11,170],"with":[12,78],"its":[13],"legume":[14],"hosts.":[15],"Within":[16],"specialized":[17],"host":[18,34,209],"cells,":[19],"S.":[20,71,205,234],"differentiates":[22],"into":[23],"highly":[24],"polyploid,":[25],"enlarged":[26],"nitrogen-fixing":[27],"bacteroids.":[28],"This":[29],"differentiation":[30,238],"is":[31],"driven":[32],"by":[33,131,178,204],"cells":[35],"through":[36,125],"production":[38],"of":[39,89,138,142,181,189],"defensin-like":[40],"peptides":[41,54,183,227],"called":[42],"\"nodule-specific":[43],"cysteine-rich\"":[44],"(NCR)":[45],"peptides.":[46,187],"Recent":[47],"research":[48],"has":[49],"shown":[50],"that":[51,97,116,135,175],"synthesized":[52],"NCR":[53,81,103,133,182,226],"exhibit":[55],"antimicrobial":[56,186],"activity":[57],"at":[58,65,91,98],"high":[59],"concentrations":[60],"but":[61],"cause":[62],"bacterial":[63],"endoreduplication":[64,236],"sublethal":[66,80,99,132,179],"concentrations.":[67],"We":[68,95],"leveraged":[69],"synchronized":[70],"populations":[73],"to":[74,207,222,232],"determine":[75],"how":[76],"treatment":[77,134],"peptide":[82,104],"affects":[83],"cell":[85,107,118,149],"cycle":[86],"and":[87,109,148,172,184,200,237],"physiology":[88],"bacteria":[90],"molecular":[93],"level.":[94],"found":[96,195],"levels":[100,180],"representative":[102],"specifically":[105],"blocks":[106],"division":[108,119,150],"antagonizes":[110],"Z-ring":[111,156],"function.":[112],"Gene-expression":[113],"profiling":[114],"revealed":[115],"block":[120],"was":[121],"produced,":[122],"in":[123,161,196,218,220],"part,":[124],"substantial":[127],"transcriptional":[128],"response":[129],"elicited":[130],"affected":[136],"\u223c15%":[137],"genome.":[140],"Expression":[141],"critical":[143],"cell-cycle":[144],"regulators,":[145],"including":[146,152],"ctrA,":[147],"genes,":[151],"genes":[153],"required":[154],"for":[155],"function,":[157],"were":[158],"greatly":[159],"attenuated":[160],"NCR-treated":[162],"cells.":[163],"In":[164],"addition,":[165],"our":[166],"experiments":[167],"identified":[168],"important":[169],"functions":[171],"stress":[173,224],"responses":[174],"are":[176,194],"induced":[177],"other":[185],"Several":[188],"these":[190],"stress-response":[191],"pathways":[192,231],"also":[193],"related":[197],"\u03b1-proteobacterial":[198],"pathogens":[199],"might":[201],"be":[202],"used":[203],"sense":[208],"cues":[210],"infection.":[212],"Our":[213],"data":[214],"suggest":[215],"model":[217],"which,":[219],"addition":[221],"provoking":[223],"responses,":[225],"target":[228],"regulatory":[230],"drive":[233],"symbiosis.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}