{"id":"https://openalex.org/W2000004849","doi":"https://doi.org/10.1088/1478-3975/6/1/016004","title":"Modeling the temporal evolution of theDrosophilagene expression from DNA microarray time series","display_name":"Modeling the temporal evolution of theDrosophilagene expression from DNA microarray time series","publication_year":2009,"publication_date":"2009-01-27","ids":{"openalex":"https://openalex.org/W2000004849","doi":"https://doi.org/10.1088/1478-3975/6/1/016004","mag":"2000004849","pmid":"https://pubmed.ncbi.nlm.nih.gov/19171963"},"language":"en","primary_location":{"id":"doi:10.1088/1478-3975/6/1/016004","doi":"https://doi.org/10.1088/1478-3975/6/1/016004","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/6/1/016004","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/6/1/016004/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iopscience.iop.org/article/10.1088/1478-3975/6/1/016004/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073526230","display_name":"Alexandre Haye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alexandre Haye","raw_affiliation_strings":["Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, Avenue Roosevelt 50, 1050 Bruxelles, Belgium. ahaye@ulb.ac.be","Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, Avenue Roosevelt 50, 1050 Bruxelles, Belgium. ahaye@ulb.ac.be","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091466337","display_name":"Yves Dehouck","orcid":"https://orcid.org/0000-0002-7401-104X","observed_orcids":["https://orcid.org/0000-0002-7401-104X"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yves Dehouck","raw_affiliation_strings":["Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037585501","display_name":"Jean Marc Kwasigroch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean Marc Kwasigroch","raw_affiliation_strings":["Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073061928","display_name":"Philippe Bogaerts","orcid":"https://orcid.org/0000-0003-0423-1933","observed_orcids":["https://orcid.org/0000-0003-0423-1933"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Bogaerts","raw_affiliation_strings":["Groupe de Mod\u00e9lisation et Contr\u00f4le de Bioproc\u00e9d\u00e9s, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Mod\u00e9lisation et Contr\u00f4le de Bioproc\u00e9d\u00e9s, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073330873","display_name":"Marianne J. Rooman","orcid":"https://orcid.org/0000-0002-3810-7802","observed_orcids":["https://orcid.org/0000-0002-3810-7802"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marianne Rooman","raw_affiliation_strings":["Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Bioinformatique G\u00e9nomique et Structurale, CP 165/61, Universit\u00e9 Libre de Bruxelles, avenue Roosevelt 50, 1050 Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":null,"fwci":0.6661,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63117757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"016004","last_page":"016004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression-dynamics","display_name":"gene expression dynamics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9589999914169312},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.5580000281333923},{"id":"https://openalex.org/keywords/differential-equation-model","display_name":"differential equation model","score":0.6800000071525574},{"id":"https://openalex.org/keywords/gene-expression-clustering","display_name":"gene expression clustering","score":0.5519999861717224},{"id":"https://openalex.org/keywords/network-parameter-reduction","display_name":"network parameter reduction","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6999326348304749},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5438942313194275},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5395718216896057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.535982072353363},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5123733282089233},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4890052080154419},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.4794943928718567},{"id":"https://openalex.org/C39927690","wikidata":"https://www.wikidata.org/wiki/Q11197","display_name":"Logarithm","level":2,"score":0.4736819565296173},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45240408182144165},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4441310465335846},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4184885025024414},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.413921058177948},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4111868441104889},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41104114055633545},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.410995215177536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32070931792259216},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.222567617893219},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12642431259155273},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.08859395980834961},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1088/1478-3975/6/1/016004","doi":"https://doi.org/10.1088/1478-3975/6/1/016004","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/6/1/016004","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/6/1/016004/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},{"id":"pmid:19171963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19171963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical biology","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/71782","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/71782","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physical biology, 6 (1","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1088/1478-3975/6/1/016004","doi":"https://doi.org/10.1088/1478-3975/6/1/016004","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/6/1/016004","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/6/1/016004/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318621","display_name":"Waalse Gewest","ror":null},{"id":"https://openalex.org/F4320334840","display_name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000004849.pdf","grobid_xml":"https://content.openalex.org/works/W2000004849.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W89551800","https://openalex.org/W1500415856","https://openalex.org/W1623155147","https://openalex.org/W1964262399","https://openalex.org/W1982583288","https://openalex.org/W2007471837","https://openalex.org/W2024991751","https://openalex.org/W2038994789","https://openalex.org/W2043102950","https://openalex.org/W2058221907","https://openalex.org/W2060393046","https://openalex.org/W2082982706","https://openalex.org/W2105581244","https://openalex.org/W2106045204","https://openalex.org/W2110012716","https://openalex.org/W2113654344","https://openalex.org/W2117392072","https://openalex.org/W2140154342","https://openalex.org/W2142631293","https://openalex.org/W2151753004","https://openalex.org/W2156435365","https://openalex.org/W2157573031","https://openalex.org/W2163296115","https://openalex.org/W2163296727","https://openalex.org/W2163296862","https://openalex.org/W2164078761","https://openalex.org/W2166106382","https://openalex.org/W2166667584","https://openalex.org/W2167155713","https://openalex.org/W2170704198","https://openalex.org/W2611370172","https://openalex.org/W3099289621","https://openalex.org/W4211104301","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2075126282","https://openalex.org/W2049232903","https://openalex.org/W1967632515","https://openalex.org/W1978129085","https://openalex.org/W1614401859","https://openalex.org/W2160315028","https://openalex.org/W7098834554","https://openalex.org/W2600569791","https://openalex.org/W7140264266","https://openalex.org/W2130029389"],"abstract_inverted_index":{"The":[0,173],"time":[1,21],"evolution":[2,25],"of":[3,10,34,42,51,64,67,89,125,140,144,158,175],"gene":[4,159,181],"expression":[5,59,95,160],"across":[6],"the":[7,11,30,35,40,47,58,62,77,87,90,113,122,129,132,135,155,176],"developmental":[8],"stages":[9],"host":[12],"organism":[13],"can":[14],"be":[15],"inferred":[16],"from":[17],"appropriate":[18],"DNA":[19],"microarray":[20],"series.":[22],"Modeling":[23],"this":[24],"aims":[26],"eventually":[27],"at":[28],"improving":[29],"understanding":[31],"and":[32,54,186],"prediction":[33],"complex":[36],"phenomena":[37],"that":[38,104,127],"are":[39,74,97],"basis":[41],"life.":[43],"We":[44,102],"focus":[45],"on":[46],"embryonic-to-adult":[48],"development":[49],"phases":[50],"Drosophila":[52],"melanogaster,":[53],"chose":[55],"to":[56,111,121,142],"model":[57,108],"network":[60,177],"with":[61,70,116,162,183,193],"help":[63],"a":[65,105,170,179],"system":[66],"differential":[68],"equations":[69],"constant":[71],"coefficients,":[72],"which":[73],"nonlinear":[75],"in":[76,82],"transcript":[78],"concentrations":[79],"but":[80],"linear":[81,107],"their":[83],"logarithms.":[84],"To":[85],"reduce":[86],"dimensionality":[88],"problem,":[91],"genes":[92],"having":[93],"similar":[94],"profiles":[96],"grouped":[98],"into":[99],"17":[100],"clusters.":[101,133],"show":[103],"simple":[106],"is":[109],"able":[110],"reproduce":[112],"experimental":[114],"data":[115],"very":[117],"good":[118,150],"precision,":[119],"owing":[120],"large":[123],"number":[124],"parameters":[126],"represent":[128],"connections":[130,146,165],"between":[131],"Remarkably,":[134],"parameter":[136],"reduction":[137],"allowed":[138],"elimination":[139],"up":[141],"80-85%":[143],"these":[145],"while":[147],"keeping":[148],"fairly":[149],"precision.":[151],"This":[152],"result":[153],"supports":[154],"low-connectivity":[156],"hypothesis":[157],"networks,":[161],"about":[163],"three":[164],"per":[166],"cluster,":[167],"without":[168],"introducing":[169],"priori":[171],"hypotheses.":[172],"core":[174],"shows":[178],"few":[180],"clusters":[182,190],"negative":[184],"self-regulation,":[185],"some":[187],"highly":[188],"connected":[189],"involving":[191],"proteins":[192],"crucial":[194],"functions.":[195]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}