{"id":"https://openalex.org/W2000003806","doi":"https://doi.org/10.1016/s0969-8051(00)00160-8","title":"Equilibrium modeling of 5-ht2a receptors with [18f]deuteroaltanserin and pet: feasibility of a constant infusion paradigm","display_name":"Equilibrium modeling of 5-ht2a receptors with [18f]deuteroaltanserin and pet: feasibility of a constant infusion paradigm","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2000003806","doi":"https://doi.org/10.1016/s0969-8051(00)00160-8","mag":"2000003806","pmid":"https://pubmed.ncbi.nlm.nih.gov/11150702"},"language":"en","primary_location":{"id":"doi:10.1016/s0969-8051(00)00160-8","doi":"https://doi.org/10.1016/s0969-8051(00)00160-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-8051(00)00160-8","pdf_url":null,"source":{"id":"https://openalex.org/S24354371","display_name":"Nuclear Medicine and Biology","issn_l":"0969-8051","issn":["0969-8051","1872-9614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine and Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0969-8051(00)00160-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112492753","display_name":"Christopher H. van Dyck","orcid":"https://orcid.org/0000-0003-1779-097X","observed_orcids":["https://orcid.org/0000-0003-1779-097X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher H van Dyck","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA. christopher.vandyck@yale.edu","Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA. christopher.vandyck@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082192669","display_name":"Jair C. Soares","orcid":"https://orcid.org/0000-0002-5466-5628","observed_orcids":["https://orcid.org/0000-0002-5466-5628"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jair C Soares","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110282477","display_name":"Ping\u2010Zhong Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping-Zhong Tan","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992224","display_name":"Julie K. Staley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie K Staley","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112761609","display_name":"Ronald M. Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M Baldwin","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109110732","display_name":"Louis Amici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis A Amici","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024268200","display_name":"Xing Fu","orcid":"https://orcid.org/0000-0001-6270-2014","observed_orcids":["https://orcid.org/0000-0001-6270-2014"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Fu","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101851189","display_name":"Pradeep Garg","orcid":"https://orcid.org/0000-0002-8874-7082","observed_orcids":["https://orcid.org/0000-0002-8874-7082"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep K Garg","raw_affiliation_strings":["Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037230816","display_name":"John Peter Seibyl","orcid":"https://orcid.org/0000-0002-4917-5413","observed_orcids":["https://orcid.org/0000-0002-4917-5413"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P Seibyl","raw_affiliation_strings":["Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012699156","display_name":"Dennis S. Charney","orcid":"https://orcid.org/0000-0003-0610-3433","observed_orcids":["https://orcid.org/0000-0003-0610-3433"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis S Charney","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079125204","display_name":"Robert B. Innis","orcid":"https://orcid.org/0000-0003-1238-7209","observed_orcids":["https://orcid.org/0000-0003-1238-7209"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B Innis","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":{"value":3740,"currency":"USD","value_usd":3740},"fwci":0.9439,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74776832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"27","issue":"8","first_page":"715","last_page":"722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.21459999680519104,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/serotonin-receptor-imaging","display_name":"serotonin receptor imaging","score":0.7160000205039978},{"id":"https://openalex.org/keywords/18f-altanserin","display_name":"[18F]altanserin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.7300000190734863},{"id":"https://openalex.org/keywords/equilibrium-modeling","display_name":"equilibrium modeling","score":0.722000002861023},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/deuteration","display_name":"deuteration","score":0.7549999952316284},{"id":"https://openalex.org/keywords/binding-potential","display_name":"binding potential","score":0.765999972820282},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6652957201004028},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6138949990272522},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5288981795310974},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.49690011143684387},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4927733242511749},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4578489363193512},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.4405204951763153},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43181324005126953},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.42327994108200073},{"id":"https://openalex.org/C202100949","wikidata":"https://www.wikidata.org/wiki/Q3229","display_name":"Positron","level":3,"score":0.41964054107666016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41102614998817444},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36793094873428345},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.35422277450561523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15417516231536865},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15182825922966003},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.133264422416687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1269834041595459},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C147120987","wikidata":"https://www.wikidata.org/wiki/Q2225","display_name":"Electron","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0969-8051(00)00160-8","doi":"https://doi.org/10.1016/s0969-8051(00)00160-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-8051(00)00160-8","pdf_url":null,"source":{"id":"https://openalex.org/S24354371","display_name":"Nuclear Medicine and Biology","issn_l":"0969-8051","issn":["0969-8051","1872-9614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine and Biology","raw_type":"journal-article"},{"id":"pmid:11150702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11150702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear medicine and biology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1016/s0969-8051(00)00160-8","doi":"https://doi.org/10.1016/s0969-8051(00)00160-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0969-8051(00)00160-8","pdf_url":null,"source":{"id":"https://openalex.org/S24354371","display_name":"Nuclear Medicine and Biology","issn_l":"0969-8051","issn":["0969-8051","1872-9614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine and Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4929264829","display_name":null,"funder_award_id":"P50-DA84733","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G744663869","display_name":null,"funder_award_id":"MH30929","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W656981833","https://openalex.org/W1489935189","https://openalex.org/W1957103591","https://openalex.org/W1968845856","https://openalex.org/W1968884554","https://openalex.org/W1978735196","https://openalex.org/W1984754451","https://openalex.org/W1998811784","https://openalex.org/W2001310902","https://openalex.org/W2004019962","https://openalex.org/W2005956625","https://openalex.org/W2010582729","https://openalex.org/W2013029069","https://openalex.org/W2017040809","https://openalex.org/W2017273367","https://openalex.org/W2026099130","https://openalex.org/W2030955576","https://openalex.org/W2046045427","https://openalex.org/W2049299233","https://openalex.org/W2050609182","https://openalex.org/W2056674018","https://openalex.org/W2057281515","https://openalex.org/W2064734750","https://openalex.org/W2073061978","https://openalex.org/W2074933088","https://openalex.org/W2081880500","https://openalex.org/W2087447249","https://openalex.org/W2091806102","https://openalex.org/W2096717001","https://openalex.org/W2112911894","https://openalex.org/W2121887890","https://openalex.org/W2134560546","https://openalex.org/W2144665117","https://openalex.org/W2184165593","https://openalex.org/W2275444639","https://openalex.org/W2321582828","https://openalex.org/W2399482264","https://openalex.org/W2950834345","https://openalex.org/W4285719527","https://openalex.org/W4319425390","https://openalex.org/W6713127076"],"related_works":["https://openalex.org/W2184165593","https://openalex.org/W2138320679","https://openalex.org/W2073383725","https://openalex.org/W2085459598","https://openalex.org/W1990605289","https://openalex.org/W2080185746","https://openalex.org/W2049299233","https://openalex.org/W2990193452","https://openalex.org/W2107021697","https://openalex.org/W2096717001"],"abstract_inverted_index":{"[(18)F]Altanserin":[0],"has":[1],"emerged":[2],"as":[3,117,232],"a":[4,27,66,72,98,118,209,233],"promising":[5],"positron":[6],"emission":[7],"tomography":[8],"(PET)":[9],"ligand":[10],"for":[11,76,102,146],"serotonin-2A":[12],"(5-HT(2A))":[13],"receptors.":[14],"The":[15,47],"deuterium":[16],"substitution":[17],"of":[18,20,23,35,50,58,86,97,105,166,169,183,218],"both":[19,147],"the":[21,51,56,84,92,136,178],"2'-hydrogens":[22],"altanserin":[24],"([(18)F]deuteroaltanserin)":[25],"yields":[26],"metabolically":[28],"more":[29],"stable":[30,60],"radiotracer":[31],"with":[32,65,107,115,203,221],"higher":[33],"ratios":[34,192],"parent":[36,175,189],"tracer":[37,79],"to":[38,90,172,186,198,230],"radiometabolites":[39],"and":[40,62,129,151,164,177,223],"increased":[41,194],"specific":[42,148,170,184],"brain":[43,63,149],"uptake":[44,150,171,185],"than":[45],"[(18)F]altanserin.":[46],"slower":[48],"metabolism":[49],"deuterated":[52],"analog":[53],"might":[54],"preclude":[55],"possibility":[57],"achieving":[59],"plasma":[61,152,174,188],"activities":[64],"bolus":[67,119],"plus":[68,120],"constant":[69,99,121],"infusion":[70,100,122,137],"within":[71],"reasonable":[73],"time":[74],"frame":[75],"an":[77],"(18)F-labeled":[78],"(T(1/2)":[80],"110":[81],"min).":[82],"Thus,":[83],"purpose":[85],"this":[87],"study":[88],"was":[89],"test":[91],"feasibility":[93,217],"in":[94,208],"human":[95],"subjects":[96,112],"paradigm":[101],"equilibrium":[103,162,219],"modeling":[104,163],"[(18)F]deuteroaltanserin":[106,116,153,222],"PET.":[108],"Seven":[109],"healthy":[110],"male":[111],"were":[113,133,193],"injected":[114],"lasting":[123],"10":[124],"h":[125],"postinjection.":[126],"PET":[127,234],"acquisitions":[128],"venous":[130],"blood":[131],"sampling":[132],"performed":[134],"throughout":[135],"period.":[138],"Linear":[139],"regression":[140],"analysis":[141],"revealed":[142],"that":[143,225],"time-activity":[144],"curves":[145],"concentration":[154],"stabilized":[155],"after":[156],"about":[157],"5":[158],"h.":[159],"This":[160],"permitted":[161],"estimation":[165],"V(')(3)":[167],"(ratio":[168,182],"total":[173],"concentration)":[176],"binding":[179],"potential":[180],"V(3)":[181],"free":[187],"concentration).":[190],"Cortical/cerebellar":[191],"by":[195],"26%":[196],"relative":[197],"those":[199],"we":[200],"previously":[201],"observed":[202],"[(18)F]altanserin":[204,231],"using":[205],"similar":[206],"methodology":[207],"somewhat":[210],"older":[211],"subject":[212],"sample.":[213],"These":[214],"results":[215],"demonstrate":[216],"imaging":[220],"suggest":[224],"it":[226],"may":[227],"be":[228],"superior":[229],"radioligand.":[235]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
