{"id":"https://openalex.org/W2000002778","doi":"https://doi.org/10.1089/hum.2004.15.921","title":"Construction of Skin Equivalents for Gene Therapy of Recessive Dystrophic Epidermolysis Bullosa","display_name":"Construction of Skin Equivalents for Gene Therapy of Recessive Dystrophic Epidermolysis Bullosa","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2000002778","doi":"https://doi.org/10.1089/hum.2004.15.921","mag":"2000002778","pmid":"https://pubmed.ncbi.nlm.nih.gov/15585108"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2004.15.921","doi":"https://doi.org/10.1089/hum.2004.15.921","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2004.15.921","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001402760","display_name":"Yannick Gache","orcid":"https://orcid.org/0000-0002-5638-4854","observed_orcids":["https://orcid.org/0000-0002-5638-4854"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yannick Gache","raw_affiliation_strings":["INSERM U634, Faculty of Medicine, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U634, Faculty of Medicine, Nice 06107, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032744232","display_name":"Christine Baldeschi","orcid":"https://orcid.org/0000-0001-6624-0507","observed_orcids":["https://orcid.org/0000-0001-6624-0507"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Baldeschi","raw_affiliation_strings":["INSERM U634, Faculty of Medicine, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U634, Faculty of Medicine, Nice 06107, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019012569","display_name":"Marcela Del R\u00edo","orcid":"https://orcid.org/0000-0003-2910-7189","observed_orcids":["https://orcid.org/0000-0003-2910-7189"]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marcela Del Rio","raw_affiliation_strings":["Centro de Investigaciones Energ\u00e9ticas, Medioambientales, y Tecnol\u00f3gicas (CIEMAT)/Fundacion Botin, Madrid 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales, y Tecnol\u00f3gicas (CIEMAT)/Fundacion Botin, Madrid 28040, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075593404","display_name":"Laurent Gagnoux-Palacios","orcid":"https://orcid.org/0000-0002-4364-8400","observed_orcids":["https://orcid.org/0000-0002-4364-8400"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Gagnoux-Palacios","raw_affiliation_strings":["INSERM U634, Faculty of Medicine, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U634, Faculty of Medicine, Nice 06107, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026078221","display_name":"Fernando Larcher","orcid":"https://orcid.org/0000-0002-6771-3561","observed_orcids":["https://orcid.org/0000-0002-6771-3561"]},"institutions":[{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando larcher","raw_affiliation_strings":["Centro de Investigaciones Energ\u00e9ticas, Medioambientales, y Tecnol\u00f3gicas (CIEMAT)/Fundacion Botin, Madrid 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales, y Tecnol\u00f3gicas (CIEMAT)/Fundacion Botin, Madrid 28040, Spain","institution_ids":["https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058938160","display_name":"J.\u2010P. Lacour","orcid":"https://orcid.org/0000-0001-7663-2053","observed_orcids":["https://orcid.org/0000-0001-7663-2053"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Lacour","raw_affiliation_strings":["Department of Dermatology, Archet II Hospital, Nice 06202, France","INSERM U634, Faculty of Medicine, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Archet II Hospital, Nice 06202, France","institution_ids":["https://openalex.org/I4210118460"]},{"raw_affiliation_string":"INSERM U634, Faculty of Medicine, Nice 06107, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029119397","display_name":"Guerrino Meneguzzi","orcid":"https://orcid.org/0000-0002-1609-6540","observed_orcids":["https://orcid.org/0000-0002-1609-6540"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guerrino Meneguzzi","raw_affiliation_strings":["INSERM U634, Faculty of Medicine, Nice 06107, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U634, Faculty of Medicine, Nice 06107, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4328,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.77078348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"15","issue":"10","first_page":"921","last_page":"933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recessive-dystrophic-epidermolysis-bullosa","display_name":"recessive dystrophic epidermolysis bullosa","score":1.0},{"id":"https://openalex.org/keywords/skin-equivalents","display_name":"skin equivalents","score":0.6830000281333923},{"id":"https://openalex.org/keywords/type-vii-collagen","display_name":"type VII collagen","score":0.7699999809265137},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/autologous-transplantation","display_name":"autologous transplantation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dermal-epidermal-junction","display_name":"basement membrane zone","score":0.7609999775886536},{"id":"https://openalex.org/keywords/anchoring-fibrils","display_name":"anchoring fibrils","score":0.8949999809265137},{"id":"https://openalex.org/keywords/genodermatoses","display_name":"genodermatosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.621999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.7450838685035706},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6519601345062256},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6352928876876831},{"id":"https://openalex.org/C2781207856","wikidata":"https://www.wikidata.org/wiki/Q923020","display_name":"Epidermolysis bullosa","level":2,"score":0.5693013668060303},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5509443283081055},{"id":"https://openalex.org/C2776559720","wikidata":"https://www.wikidata.org/wiki/Q3589131","display_name":"Epidermolysis bullosa dystrophica","level":3,"score":0.5032421946525574},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.47542455792427063},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4470045566558838},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44320148229599},{"id":"https://openalex.org/C19218775","wikidata":"https://www.wikidata.org/wiki/Q22325581","display_name":"Anchoring fibrils","level":3,"score":0.43620193004608154},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.43479734659194946},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4105467200279236},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39799895882606506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36491990089416504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34660375118255615},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3423789143562317},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3220396041870117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3038431704044342},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2944467067718506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2347278892993927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20871785283088684},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14691421389579773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11036211252212524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09111806750297546},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.090343177318573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005808","descriptor_name":"Genes, Recessive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016108","descriptor_name":"Epidermolysis Bullosa Dystrophica","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016108","descriptor_name":"Epidermolysis Bullosa Dystrophica","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024143","descriptor_name":"Collagen Type VII","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.2004.15.921","doi":"https://doi.org/10.1089/hum.2004.15.921","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2004.15.921","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:15585108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15585108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310237","display_name":"Dystrophic Epidermolysis Bullosa Research Association","ror":"https://ror.org/04pzgj087"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W171288215","https://openalex.org/W1482923899","https://openalex.org/W1489122921","https://openalex.org/W1509401342","https://openalex.org/W1966467525","https://openalex.org/W1969868956","https://openalex.org/W1977225005","https://openalex.org/W1989780033","https://openalex.org/W1990832407","https://openalex.org/W1992953131","https://openalex.org/W2000482931","https://openalex.org/W2000919184","https://openalex.org/W2002607527","https://openalex.org/W2002983419","https://openalex.org/W2003036450","https://openalex.org/W2003336954","https://openalex.org/W2005356516","https://openalex.org/W2006495963","https://openalex.org/W2011293012","https://openalex.org/W2013373938","https://openalex.org/W2016314932","https://openalex.org/W2016463554","https://openalex.org/W2021320569","https://openalex.org/W2022020534","https://openalex.org/W2026395301","https://openalex.org/W2026901855","https://openalex.org/W2030646994","https://openalex.org/W2042079025","https://openalex.org/W2045934824","https://openalex.org/W2049043712","https://openalex.org/W2056607908","https://openalex.org/W2059831153","https://openalex.org/W2067756121","https://openalex.org/W2074869094","https://openalex.org/W2074962579","https://openalex.org/W2093125863","https://openalex.org/W2100837269","https://openalex.org/W2105886061","https://openalex.org/W2108165825","https://openalex.org/W2115774235","https://openalex.org/W2118813767","https://openalex.org/W2150722878","https://openalex.org/W2152708430","https://openalex.org/W2168211018","https://openalex.org/W2171546300","https://openalex.org/W2174586231","https://openalex.org/W2327567234","https://openalex.org/W2413282957","https://openalex.org/W2427950220","https://openalex.org/W2729475883","https://openalex.org/W4249221261"],"related_works":["https://openalex.org/W2171546300","https://openalex.org/W2346556008","https://openalex.org/W2021320569","https://openalex.org/W2065114016","https://openalex.org/W1995787970","https://openalex.org/W2338965223","https://openalex.org/W4241009764","https://openalex.org/W2016150075","https://openalex.org/W4366190871","https://openalex.org/W2790488519"],"abstract_inverted_index":{"We":[0],"have":[1,42],"shown":[2],"that":[3,80],"retroviral":[4,47,211],"vectors":[5,48,212],"efficiently":[6,111],"transfer":[7],"the":[8,28,44,88,97,103,114,123,144,159,170,198,217],"9-kb":[9],"collagen":[10,52,77,93],"type":[11,53,78,94],"VII":[12,54,79,95],"cDNA":[13,55],"into":[14,56,82,87],"keratinocytes":[15,60,70,106,147],"of":[16,27,46,75,102,118,130,172,179,202,220],"dogs":[17],"with":[18,122,134,143,158,168],"recessive":[19],"dystrophic":[20],"epidermolysis":[21],"bullosa":[22],"(RDEB)":[23],"and":[24,61,99,109,126,148,164],"achieve":[25],"correction":[26],"RDEB":[29,59,69,105,136,146,204],"phenotype":[30],"in":[31,107,156,216],"vitro.":[32],"As":[33],"a":[34],"next":[35],"step":[36],"toward":[37],"gene":[38],"therapy":[39],"applications,":[40],"we":[41],"assessed":[43],"suitability":[45],"to":[49,188],"transduce":[50],"human":[51,58,174],"primary":[57,203],"generate":[62],"transplantable":[63,183],"autologous":[64],"skin":[65,120,140,194],"equivalents.":[66],"The":[67,91],"transduced":[68,104,145],"permanently":[71],"express":[72],"high":[73],"levels":[74],"recombinant":[76,92,210],"assembles":[81],"functional":[83],"homotrimers":[84],"readily":[85],"secreted":[86],"extracellular":[89],"matrix.":[90],"reverts":[96],"migration":[98],"invasion":[100],"potential":[101],"vitro":[108],"is":[110],"deposited":[112],"at":[113],"dermal":[115,135],"epidermal":[116,205],"junction":[117],"artificial":[119,127],"prepared":[121],"reverted":[124],"cells":[125,207],"dermis":[128],"made":[129,142],"biomaterial":[131],"sponges":[132],"embedded":[133],"fibroblasts.":[137],"Transplantable":[138],"fibrin-based":[139],"equivalents":[141],"grafted":[149],"onto":[150],"SCID":[151],"mice":[152],"either":[153],"orthotopically":[154],"or":[155,195],"accordance":[157],"flap":[160],"method":[161],"generated":[162],"cohesive":[163],"orderly":[165],"stratified":[166],"epithelia":[167,184],"all":[169],"characteristics":[171],"normal":[173],"epidermis,":[175],"including":[176],"rapid":[177],"formation":[178],"anchoring":[180],"fibrils.":[181],"Because":[182],"are":[185],"routinely":[186],"used":[187],"cure":[189],"patients":[190],"suffering":[191],"from":[192],"large":[193],"mucosal":[196],"defects,":[197],"full":[199],"phenotypic":[200],"reversion":[201],"clonogenic":[206],"mediated":[208],"by":[209],"opens":[213],"new":[214],"perspectives":[215],"long-term":[218],"treatment":[219],"genodermatoses.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
