{"id":"https://openalex.org/W2000002633","doi":"https://doi.org/10.1016/j.eurpsy.2012.03.004","title":"The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive disorder","display_name":"The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive disorder","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2000002633","doi":"https://doi.org/10.1016/j.eurpsy.2012.03.004","mag":"2000002633","pmid":"https://pubmed.ncbi.nlm.nih.gov/22944336"},"language":"en","primary_location":{"id":"doi:10.1016/j.eurpsy.2012.03.004","doi":"https://doi.org/10.1016/j.eurpsy.2012.03.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2012.03.004","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013969466","display_name":"B. J. Hasselbalch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"B.J. Hasselbalch","raw_affiliation_strings":["Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. jacob.hasselbalch@regionh.dk","Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. jacob.hasselbalch@regionh.dk","institution_ids":["https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007536391","display_name":"Ulla Knorr","orcid":"https://orcid.org/0000-0002-1222-1527","observed_orcids":["https://orcid.org/0000-0002-1222-1527"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"U. Knorr","raw_affiliation_strings":["Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052942530","display_name":"Steen Gregers Hasselbalch","orcid":"https://orcid.org/0000-0003-4750-4911","observed_orcids":["https://orcid.org/0000-0003-4750-4911"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S.G. Hasselbalch","raw_affiliation_strings":["Neurobiology Research Unit and Memory Disorders Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology Research Unit and Memory Disorders Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036468991","display_name":"Anders Gade","orcid":"https://orcid.org/0000-0001-5872-056X","observed_orcids":["https://orcid.org/0000-0001-5872-056X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A. Gade","raw_affiliation_strings":["Department of Psychology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074715169","display_name":"Lars Vedel Kessing","orcid":"https://orcid.org/0000-0001-9377-9436","observed_orcids":["https://orcid.org/0000-0001-9377-9436"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"L.V. Kessing","raw_affiliation_strings":["Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013969466"],"corresponding_institution_ids":["https://openalex.org/I2802567020"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":4.3102,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.9404688,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"6","first_page":"349","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.5950000286102295},{"id":"https://openalex.org/keywords/remitted-depression","display_name":"remitted depression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/psychotic-features","display_name":"psychotic features","score":0.628000020980835},{"id":"https://openalex.org/keywords/episode-duration","display_name":"episode duration","score":0.722000002861023},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cambridge-cognitive-examination","display_name":"CAMCOG","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6354243755340576},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6241116523742676},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5811254978179932},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5535580515861511},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.5076247453689575},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4316256046295166},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33907943964004517},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.eurpsy.2012.03.004","doi":"https://doi.org/10.1016/j.eurpsy.2012.03.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2012.03.004","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},{"id":"pmid:22944336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22944336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European psychiatry : the journal of the Association of European Psychiatrists","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/cb61fd93-56c3-45d4-99c0-11bdc7668378","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/cb61fd93-56c3-45d4-99c0-11bdc7668378","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hasselbalch , B J , Ulla , K , Hasselbalch , S , Gade , A & Kessing , L V 2013 , ' The cumulative load of depressive illness is associated with cogntiive function in the remitted state of unipolar depressive disorder. ' , European Psychiatry , vol. 28 , pp. 349-355 .","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3387420079","display_name":null,"funder_award_id":"R17-2007-1798","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W119012150","https://openalex.org/W1580823350","https://openalex.org/W1651468703","https://openalex.org/W1968080961","https://openalex.org/W1979253763","https://openalex.org/W1979532918","https://openalex.org/W1981748148","https://openalex.org/W1982923747","https://openalex.org/W1992643054","https://openalex.org/W1993093741","https://openalex.org/W1997423129","https://openalex.org/W1998911276","https://openalex.org/W2000717079","https://openalex.org/W2004649797","https://openalex.org/W2004752393","https://openalex.org/W2005650640","https://openalex.org/W2014550164","https://openalex.org/W2019884656","https://openalex.org/W2024126239","https://openalex.org/W2029064583","https://openalex.org/W2030156534","https://openalex.org/W2030380365","https://openalex.org/W2032149427","https://openalex.org/W2036571422","https://openalex.org/W2037914981","https://openalex.org/W2060710107","https://openalex.org/W2071401336","https://openalex.org/W2076782400","https://openalex.org/W2077455126","https://openalex.org/W2081353032","https://openalex.org/W2083733140","https://openalex.org/W2084865691","https://openalex.org/W2089158781","https://openalex.org/W2093590776","https://openalex.org/W2096492990","https://openalex.org/W2097812147","https://openalex.org/W2099301748","https://openalex.org/W2103000760","https://openalex.org/W2103514611","https://openalex.org/W2114613490","https://openalex.org/W2118202495","https://openalex.org/W2121878996","https://openalex.org/W2124571614","https://openalex.org/W2128567888","https://openalex.org/W2142589250","https://openalex.org/W2153825927","https://openalex.org/W2164066379","https://openalex.org/W2165071787","https://openalex.org/W2166700666","https://openalex.org/W2166942831","https://openalex.org/W2169716279","https://openalex.org/W2952072306","https://openalex.org/W2973691898","https://openalex.org/W4413981594","https://openalex.org/W6764536387"],"related_works":["https://openalex.org/W3013453653","https://openalex.org/W4412258699","https://openalex.org/W2103000760","https://openalex.org/W7214776033","https://openalex.org/W2166700666","https://openalex.org/W2967632421","https://openalex.org/W2105532150","https://openalex.org/W2126079885","https://openalex.org/W2520296387","https://openalex.org/W1077049090"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"whether":[3],"the":[4,40,70,88,117,124,166,189,205],"cumulative":[5,127,167,190],"number,":[6],"duration":[7,128,168,191],"and":[8,11,46,75,78,108,120,146,165,169,195],"subtypes":[9],"(severity":[10],"presence":[12],"of":[13,16,19,49,58,98,105,129,172,192,207,214,217],"psychotic":[14,176,202],"features)":[15],"previous":[17],"episodes":[18,131,174,200],"depression":[20],"in":[21,27,69,123,197,204],"patients":[22,54,107],"with":[23,33,55,87,134,175,188,201],"unipolar":[24,59],"depressive":[25,130,148,173,193,199],"disorder":[26,60],"a":[28,56,66,95,135,211],"remitted":[29],"state":[30],"are":[31],"associated":[32,133,187],"decreased":[34,136],"global":[35,99],"cognitive":[36,100,184,218],"function.":[37,101,219],"METHODS:":[38],"Via":[39],"Danish":[41],"registers":[42],"individuals":[43],"between":[44,162],"40":[45],"80":[47],"years":[48],"age":[50,79],"were":[51,85,121,159],"identified:":[52],"(1)":[53],"diagnosis":[57],"at":[61],"their":[62],"first":[63],"discharge":[64],"from":[65],"psychiatric":[67],"hospital":[68],"period":[71],"1994":[72],"to":[73,114],"2002,":[74],"(2)":[76],"gender":[77],"matched":[80],"control":[81],"individuals.":[82],"The":[83,126],"participants":[84],"assessed":[86],"Cambridge":[89],"Cognitive":[90],"Examination":[91],"(CAMCOG),":[92],"which":[93],"provides":[94],"composite":[96],"measure":[97],"RESULTS:":[102],"A":[103],"total":[104,170],"88":[106],"50":[109],"controls":[110],"accepted":[111],"our":[112],"invitation":[113],"participate,":[115],"fulfilled":[116],"selection":[118],"criteria":[119],"included":[122],"study.":[125],"was":[132],"CAMCOG":[137,163],"score":[138,164],"adjusted":[139],"for":[140],"age,":[141],"gender,":[142],"education,":[143],"premorbid":[144],"IQ":[145],"residual":[147],"symptoms":[149],"(B=-0.14,":[150],"95%":[151],"C.I.":[152],"(-0.26,":[153],"-0.02),":[154],"R(2)adj=0.31,":[155],"P=.02).":[156],"Significant":[157],"associations":[158],"also":[160],"found":[161],"number":[171],"features,":[177],"respectively.":[178],"CONCLUSION:":[179],"Our":[180],"findings":[181],"suggest":[182],"that":[183],"dysfunction":[185],"is":[186],"episodes,":[194],"that,":[196],"particular,":[198],"features":[203],"course":[206],"illness":[208],"may":[209],"be":[210],"significant":[212],"predictor":[213],"future":[215],"impairment":[216]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}