{"id":"https://openalex.org/W2000002418","doi":"https://doi.org/10.1186/1756-0500-1-20","title":"Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease","display_name":"Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease","publication_year":2008,"publication_date":"2008-06-04","ids":{"openalex":"https://openalex.org/W2000002418","doi":"https://doi.org/10.1186/1756-0500-1-20","mag":"2000002418","pmid":"https://pubmed.ncbi.nlm.nih.gov/18710535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2518273"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0500-1-20","doi":"https://doi.org/10.1186/1756-0500-1-20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-1-20","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-1-20","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-1-20","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031702923","display_name":"Sachin P. Patil","orcid":"https://orcid.org/0000-0002-1354-0386","observed_orcids":["https://orcid.org/0000-0002-1354-0386"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sachin Patil","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA. patilsac@msu.edu","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA. patilsac@msu.edu","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047346217","display_name":"Deebika Balu","orcid":"https://orcid.org/0009-0008-3245-2905","observed_orcids":["https://orcid.org/0009-0008-3245-2905"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deebika Balu","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041181178","display_name":"Joseph Melrose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Melrose","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0000-0003-3054-2727","observed_orcids":["https://orcid.org/0000-0003-3054-2727","https://orcid.org/0009-0003-7693-8206"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina Chan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, Michigan, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102757744"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.6152,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.59735862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"20","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9120000004768372},{"id":"https://openalex.org/keywords/free-fatty-acid-metabolism","display_name":"free fatty acid metabolism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.6460000276565552},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.7347496747970581},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6089860796928406},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.60202956199646},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4902270436286926},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4884559214115143},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.4580196142196655},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4504096806049347},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.4411288797855377},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42554718255996704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39223405718803406},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.31005221605300903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2904648780822754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2640393376350403},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26117467880249023},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2064380943775177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1114467978477478}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1756-0500-1-20","doi":"https://doi.org/10.1186/1756-0500-1-20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-1-20","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-1-20","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},{"id":"pmid:18710535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18710535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC research notes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2518273","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2518273/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Res Notes","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.3550","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.3550","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/72/df/BMC_Res_Notes_2008_Jun_4_1_20.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4e459caf44be4ad8b75a12f9e2533a86","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4e459caf44be4ad8b75a12f9e2533a86","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Research Notes, Vol 1, Iss 1, p 20 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1756-0500-1-20","doi":"https://doi.org/10.1186/1756-0500-1-20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-1-20","pdf_url":"https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-1-20","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3065287108","display_name":"QSB:  Quantitative Systems Approach to Hepatic Metabolism:  To Elucidate the Effect of Tumor Necrosis Factor-alpha","funder_award_id":"0331297","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4516757180","display_name":"QSB: Unraveling Palmitate-induced Apoptosis and Oleate-conferred Cytoprotection by Systems Analysis and RNA Interference","funder_award_id":"0425821","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5168733168","display_name":"Develop a Dynamic Model that Incoporates Text-mining to Reconstruct Networks","funder_award_id":"R01GM079688","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320316470","display_name":"Michigan State University Foundation","ror":"https://ror.org/04njz3m02"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000002418.pdf","grobid_xml":"https://content.openalex.org/works/W2000002418.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1577397450","https://openalex.org/W1841303832","https://openalex.org/W1863276550","https://openalex.org/W1916645464","https://openalex.org/W1988865401","https://openalex.org/W1989104104","https://openalex.org/W2005826876","https://openalex.org/W2008774076","https://openalex.org/W2017560509","https://openalex.org/W2023899218","https://openalex.org/W2030646074","https://openalex.org/W2035703501","https://openalex.org/W2041895791","https://openalex.org/W2054384828","https://openalex.org/W2059962058","https://openalex.org/W2073636275","https://openalex.org/W2080274663","https://openalex.org/W2087496358","https://openalex.org/W2095405363","https://openalex.org/W2121028686","https://openalex.org/W2144918294","https://openalex.org/W2152907424","https://openalex.org/W2162446362","https://openalex.org/W2164735970","https://openalex.org/W2402085289","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1863276550","https://openalex.org/W7095333065","https://openalex.org/W2008774076","https://openalex.org/W2017560509","https://openalex.org/W2034807178","https://openalex.org/W3022307835","https://openalex.org/W4405855625","https://openalex.org/W2167230895","https://openalex.org/W3176409637","https://openalex.org/W2020752833"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alzheimer's":[1],"disease":[2,8],"(AD)":[3],"is":[4,20,32],"a":[5,53,187],"progressive,":[6],"neurodegenerative":[7],"mostly":[9],"affecting":[10],"the":[11,18,48,59,99,104,108,131,166],"basal":[12],"forebrain,":[13],"cortex":[14,75,194],"and":[15,80,117,140,152],"hippocampus":[16],"whereas":[17],"cerebellum":[19,81],"relatively":[21],"spared.":[22],"The":[23,67,92,121,158],"reason":[24],"behind":[25],"this":[26],"region-specific":[27,60,167],"brain":[28,50,73],"damage":[29,61,168],"in":[30,47,57,63,78,142,170,190,195],"AD":[31,64,171],"not":[33,130],"well":[34],"understood.":[35],"Here,":[36],"we":[37],"report":[38],"our":[39],"data":[40,160],"suggesting":[41],"\"differential":[42],"free":[43],"fatty":[44,174],"acid":[45],"metabolism":[46],"different":[49,71],"areas\"":[51],"as":[52,145,180],"potentially":[54],"important":[55],"factor":[56],"causing":[58],"observed":[62,169],"brain.":[65],"FINDINGS:":[66],"astroglia":[68,179],"from":[69,124],"two":[70,109],"rat":[72],"regions,":[74],"(region":[76],"affected":[77],"AD)":[79],"(unaffected":[82],"region),":[83],"were":[84,95],"treated":[85,126],"with":[86],"0.2":[87],"mM":[88],"of":[89,119,137,177,193],"palmitic":[90],"acid.":[91],"conditioned":[93,122],"media":[94,123],"then":[96],"transferred":[97],"to":[98,102,147,182],"cortical":[100,127,143,178],"neurons":[101,144],"study":[103],"possible":[105],"effects":[106],"on":[107],"main,":[110],"AD-associated":[111],"protein":[112],"abnormalities,":[113],"viz.":[114],"BACE1":[115,141],"upregulation":[116],"hyperphosphorylation":[118],"tau.":[120],"palmitic-acid":[125],"astroglia,":[128,133,184],"but":[129],"cerebellar":[132,183],"significantly":[134],"elevated":[135],"levels":[136],"phosphorylated":[138],"tau":[139],"compared":[146,181],"controls":[148],"(47":[149],"+/-":[150,154],"7%":[151],"45":[153],"4%,":[155],"respectively).":[156],"CONCLUSION:":[157],"present":[159],"provide":[161],"an":[162],"experimental":[163],"explanation":[164],"for":[165],"brain;":[172],"higher":[173],"acid-metabolizing":[175],"capacity":[176],"may":[185],"play":[186],"causal":[188],"role":[189],"increasing":[191],"vulnerability":[192],"AD,":[196],"while":[197],"sparing":[198],"cerebellum.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
