{"id":"https://openalex.org/W2000002177","doi":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","title":"Activation of Nuclear Factor kappa B and Severe Hepatic Necrosis May Mediate Systemic Inflammation in Choline-deficient/Ethionine-supplemented Diet-induced Pancreatitis","display_name":"Activation of Nuclear Factor kappa B and Severe Hepatic Necrosis May Mediate Systemic Inflammation in Choline-deficient/Ethionine-supplemented Diet-induced Pancreatitis","publication_year":2006,"publication_date":"2006-09-25","ids":{"openalex":"https://openalex.org/W2000002177","doi":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","mag":"2000002177","pmid":"https://pubmed.ncbi.nlm.nih.gov/17003648"},"language":"en","primary_location":{"id":"doi:10.1097/01.mpa.0000240599.95817.34","doi":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108499350","display_name":"Keith D. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keith D. Gray","raw_affiliation_strings":["Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA","Department of Surgery, Vanderbilt University Medical Center, Nashville TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028650763","display_name":"Misho O. Simovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misho O. Simovic","raw_affiliation_strings":["Department of Surgery, Meharry Medical College, Nashville, TN","Meharry Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Meharry Medical College, Nashville, TN","institution_ids":["https://openalex.org/I118073183"]},{"raw_affiliation_string":"Meharry Medical College","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063872240","display_name":"Timothy S. Blackwell","orcid":"https://orcid.org/0000-0002-0337-7052","observed_orcids":["https://orcid.org/0000-0002-0337-7052"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Blackwell","raw_affiliation_strings":["Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, and the Department of Veterans Affairs, Nashville, TN","Department of Veterans Affairs","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, and the Department of Veterans Affairs, Nashville, TN","institution_ids":["https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Veterans Affairs","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081819707","display_name":"John William Christman","orcid":"https://orcid.org/0000-0001-6926-9313","observed_orcids":["https://orcid.org/0000-0001-6926-9313"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Christman","raw_affiliation_strings":["Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, and the Department of Veterans Affairs, Nashville, TN","Department of Veterans Affairs","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, and the Department of Veterans Affairs, Nashville, TN","institution_ids":["https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Veterans Affairs","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085685364","display_name":"Addison K. May","orcid":"https://orcid.org/0000-0002-6496-3733","observed_orcids":["https://orcid.org/0000-0002-6496-3733"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Addison K. May","raw_affiliation_strings":["Department of Surgery, Trauma Division, Vanderbilt University Medical Center, Nashville, TN","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Trauma Division, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056084098","display_name":"Kelly S. Parman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly S. Parman","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082082558","display_name":"William C. Chapman","orcid":"https://orcid.org/0000-0002-7602-5445","observed_orcids":["https://orcid.org/0000-0002-7602-5445","https://orcid.org/0000-0002-0072-3239"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Chapman","raw_affiliation_strings":["Department of Surgery, Washington University, St Louis, MO","Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011676816","display_name":"Steven Charles Stain","orcid":"https://orcid.org/0000-0002-4540-7459","observed_orcids":["https://orcid.org/0000-0002-4540-7459"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven C. Stain","raw_affiliation_strings":["Department of Surgery, Meharry Medical College, Nashville, TN","Department of Surgery, Vanderbilt University Medical Center, Nashville, TN","Albany Medical College","Meharry Medical College","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Meharry Medical College, Nashville, TN","institution_ids":["https://openalex.org/I118073183"]},{"raw_affiliation_string":"Department of Surgery, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Albany Medical College","institution_ids":["https://openalex.org/I4405260259"]},{"raw_affiliation_string":"Meharry Medical College","institution_ids":["https://openalex.org/I118073183"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5011676816","https://openalex.org/A5108499350"],"corresponding_institution_ids":["https://openalex.org/I118073183","https://openalex.org/I200719446","https://openalex.org/I4405260259","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":3.1146,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90716249,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"3","first_page":"260","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-acute-pancreatitis","display_name":"severe acute pancreatitis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.843999981880188},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7590000033378601},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6819999814033508},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.890999972820282},{"id":"https://openalex.org/keywords/keratinocyte-derived-chemokine","display_name":"keratinocyte-derived chemokine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/choline-deficient-ethionine-supplemented-diet","display_name":"choline-deficient ethionine-supplemented diet","score":0.925000011920929},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.757919192314148},{"id":"https://openalex.org/C2780486903","wikidata":"https://www.wikidata.org/wiki/Q27137089","display_name":"Ethionine","level":4,"score":0.560396671295166},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5113136768341064},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4888855516910553},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4819038212299347},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.46136775612831116},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4447340965270996},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44281908869743347},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43645668029785156},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.40042054653167725},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38586294651031494},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.38166171312332153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36286646127700806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3486834764480591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33048367500305176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32833045721054077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31879323720932007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08067375421524048},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005001","descriptor_name":"Ethionine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.mpa.0000240599.95817.34","doi":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000240599.95817.34","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},{"id":"pmid:17003648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17003648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W105279024","https://openalex.org/W1487473377","https://openalex.org/W1502126027","https://openalex.org/W1562554339","https://openalex.org/W1579488798","https://openalex.org/W1967846605","https://openalex.org/W1972838290","https://openalex.org/W1974173581","https://openalex.org/W1983614838","https://openalex.org/W1995261608","https://openalex.org/W1999415038","https://openalex.org/W2024397408","https://openalex.org/W2029765941","https://openalex.org/W2031698398","https://openalex.org/W2042812804","https://openalex.org/W2042966982","https://openalex.org/W2043777739","https://openalex.org/W2047204509","https://openalex.org/W2055817721","https://openalex.org/W2057311622","https://openalex.org/W2057639891","https://openalex.org/W2068332574","https://openalex.org/W2068703154","https://openalex.org/W2070678323","https://openalex.org/W2075593832","https://openalex.org/W2089204108","https://openalex.org/W2090405394","https://openalex.org/W2094731265","https://openalex.org/W2095039917","https://openalex.org/W2097837602","https://openalex.org/W2118396663","https://openalex.org/W2128635872","https://openalex.org/W2131634572","https://openalex.org/W2136771298","https://openalex.org/W2138670998","https://openalex.org/W2148000616","https://openalex.org/W2149627043","https://openalex.org/W2164754954","https://openalex.org/W2217143514","https://openalex.org/W2263642011","https://openalex.org/W2462435973","https://openalex.org/W3184628723"],"related_works":["https://openalex.org/W1898984969","https://openalex.org/W2270779400","https://openalex.org/W79815117","https://openalex.org/W2901952453","https://openalex.org/W3201559767","https://openalex.org/W2188707701","https://openalex.org/W2335356391","https://openalex.org/W4307976043","https://openalex.org/W2260749121","https://openalex.org/W2782305621"],"abstract_inverted_index":{"OBJECTIVES:":[0],"We":[1],"hypothesized":[2],"that":[3],"hepatic":[4,86,195,281],"injury":[5,18,46,153,276],"is":[6,267,277],"associated":[7,47,278],"with":[8,48,251,269,279],"severe":[9],"acute":[10],"pancreatitis":[11],"(SAP)":[12],"and":[13,32,39,118,127,150,159,164,174,191,208,221,226,234,248,255,272,291],"may":[14,297],"result":[15],"in":[16,41,55,91,123,161,214,236,260,293],"lung":[17,128,139,237,300],"through":[19],"nuclear":[20,92],"factor":[21,109],"kappa":[22],"B":[23],"(NF-kappaB)-dependent":[24],"inflammatory":[25,114,257],"mediators.":[26],"The":[27,51,63,88,136,148],"study":[28],"characterizes":[29],"the":[30,34,42,83,178,261,280,286,294,299],"timing":[31],"determines":[33],"involvement":[35],"of":[36,44,85,125,217,232,288],"selected":[37],"cytokines":[38,290],"chemokines":[40,292],"pathogenesis":[43],"hepatocellular":[45,168,215,270],"SAP.":[49],"METHODS:":[50],"SAP":[52,149,266],"was":[53,79,98,141,170,200],"induced":[54],"C57BL/6":[56],"mice":[57,64],"by":[58,132,156,181,210],"feeding":[59],"a":[60,101,211],"choline-deficient/ethionine-supplemented":[61],"diet.":[62],"were":[65,130,154,239],"killed":[66],"at":[67,172,202,223,242],"12-hour":[68],"intervals":[69],"for":[70],"96":[71],"hours.":[72],"Terminal":[73],"deoxynucleotidyl":[74,183],"transferase-mediated":[75,184],"nick-end":[76,185],"labeling":[77,186],"staining":[78,187],"used":[80],"to":[81,194,285],"determine":[82],"extent":[84],"apoptosis.":[87],"NF-kappaB":[89,198,282],"activation":[90,199,283],"protein":[93,115],"extracts":[94],"from":[95],"liver":[96,126,152],"tissue":[97,144,238],"measured":[99,131,142],"using":[100],"sensitive":[102],"RelA":[103],"enzyme-linked":[104,133],"immunoadsorbent":[105,134],"assay.":[106,135],"Tumor":[107],"necrosis":[108],"alpha,":[110],"interleukin":[111,218],"6,":[112,219],"macrophage":[113],"(MIP)":[116],"2,":[117],"keratinocyte-derived":[119],"chemokine":[120],"(KC)":[121],"levels":[122,216],"homogenates":[124],"tissues":[129],"SAP-associated":[137],"neutrophil":[138],"inflammation":[140],"as":[143],"myeloperoxidase":[145,253],"activity.":[146],"RESULTS:":[147],"subsequent":[151],"confirmed":[155],"histological":[157],"analysis":[158],"rises":[160],"plasma":[162],"amylase":[163],"transaminase":[165],"levels.":[166],"Severe":[167],"apoptosis":[169,271],"detected":[171,201],"36":[173,203],"48":[175],"hours":[176,204,225,244],"after":[177],"diet":[179],"initiation":[180],"terminal":[182],"(P":[188,205,228,245],"<":[189,206,229,246],"0.05)":[190,207,247],"subsequently":[192],"progressed":[193],"necrosis.":[196,274],"Liver":[197],"followed":[209],"sharp":[212],"increase":[213],"MIP-2,":[220],"KC":[222,235],"72":[224,243],"thereafter":[227],"0.05).":[230],"Levels":[231],"MIP-2":[233],"also":[240],"elevated":[241],"closely":[249],"correlated":[250],"increased":[252,256],"activity":[254],"cell":[258],"infiltrate":[259],"lung.":[262],"CONCLUSIONS:":[263],"Choline-deficient/ethionine-supplemented":[264],"diet-induced":[265],"accompanied":[268],"eventual":[273],"This":[275],"leading":[284],"production":[287],"NF-kappaB-dependent":[289],"liver,":[295],"which":[296],"mediate":[298],"injury.":[301]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}