{"id":"https://openalex.org/W1999665276","doi":"https://doi.org/10.1097/aln.0b013e31825575e6","title":"Transfusion of Stored Autologous Blood Does Not Alter Reactive Hyperemia Index in Healthy Volunteers","display_name":"Transfusion of Stored Autologous Blood Does Not Alter Reactive Hyperemia Index in Healthy Volunteers","publication_year":2012,"publication_date":"2012-04-24","ids":{"openalex":"https://openalex.org/W1999665276","doi":"https://doi.org/10.1097/aln.0b013e31825575e6","mag":"1999665276","pmid":"https://pubmed.ncbi.nlm.nih.gov/22531338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3980575"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0b013e31825575e6","doi":"https://doi.org/10.1097/aln.0b013e31825575e6","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31825575e6","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/117/1/56/658785/0000542-201207000-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/117/1/56/658785/0000542-201207000-00016.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079746187","display_name":"Lorenzo M. Berra","orcid":"https://orcid.org/0000-0003-2702-2093","observed_orcids":["https://orcid.org/0000-0003-2702-2093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenzo Berra","raw_affiliation_strings":["Assistant Professor of Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Anesthesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053981133","display_name":"Andrea Coppadoro","orcid":"https://orcid.org/0000-0003-1759-4071","observed_orcids":["https://orcid.org/0000-0003-1759-4071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Coppadoro","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004313751","display_name":"Binglan Yu","orcid":"https://orcid.org/0000-0001-5496-2131","observed_orcids":["https://orcid.org/0000-0001-5496-2131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binglan Yu","raw_affiliation_strings":["Instructor in Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instructor in Anesthesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016631374","display_name":"Chong Lei","orcid":"https://orcid.org/0000-0003-4259-4479","observed_orcids":["https://orcid.org/0000-0003-4259-4479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chong Lei","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060759357","display_name":"Ester Spagnolli","orcid":"https://orcid.org/0000-0002-3687-2113","observed_orcids":["https://orcid.org/0000-0002-3687-2113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ester Spagnolli","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054777906","display_name":"Andrea Ulrike Steinbicker","orcid":"https://orcid.org/0000-0002-5237-961X","observed_orcids":["https://orcid.org/0000-0002-5237-961X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea\u00a0U. Steinbicker","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101301","display_name":"Kenneth D. Bloch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth\u00a0D. Bloch","raw_affiliation_strings":["Professor of Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Anesthesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tian Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tian Lin","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110230072","display_name":"Fatima Sammy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatima\u00a0Y. Sammy","raw_affiliation_strings":["Technician"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technician","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081605842","display_name":"H. Shaw Warren","orcid":"https://orcid.org/0009-0005-1128-7056","observed_orcids":["https://orcid.org/0009-0005-1128-7056"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.\u00a0Shaw Warren","raw_affiliation_strings":["Associate Professor of Pediatrics, Infectious Disease Unit, Harvard Medical School at Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Pediatrics, Infectious Disease Unit, Harvard Medical School at Massachusetts General Hospital","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050463541","display_name":"Bernadette O. Fernandez","orcid":"https://orcid.org/0000-0001-6337-0381","observed_orcids":["https://orcid.org/0000-0001-6337-0381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernadette\u00a0O. Fernandez","raw_affiliation_strings":["Postdoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postdoctoral Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036280404","display_name":"Martin Feelisch","orcid":"https://orcid.org/0000-0003-2320-1158","observed_orcids":["https://orcid.org/0000-0003-2320-1158"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Feelisch","raw_affiliation_strings":["Professor of Experimental Medicine and Integrative Biology, Department of Medicine and Biology, University of Warwick Medical School, Coventry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Experimental Medicine and Integrative Biology, Department of Medicine and Biology, University of Warwick Medical School, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065966636","display_name":"Sunny Dzik","orcid":"https://orcid.org/0000-0003-3844-4371","observed_orcids":["https://orcid.org/0000-0003-3844-4371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter\u00a0H. Dzik","raw_affiliation_strings":["Associate Professor of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058609949","display_name":"Christopher P. Stowell","orcid":"https://orcid.org/0000-0003-1548-6085","observed_orcids":["https://orcid.org/0000-0003-1548-6085"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher\u00a0P. Stowell","raw_affiliation_strings":["Assistant Professor of Pathology, Blood Transfusion Service, Department of Pathology, Harvard Medical School at Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Pathology, Blood Transfusion Service, Department of Pathology, Harvard Medical School at Massachusetts General Hospital","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073059702","display_name":"Warren M. Zapol","orcid":"https://orcid.org/0000-0002-0359-3660","observed_orcids":["https://orcid.org/0000-0002-0359-3660"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren\u00a0M. Zapol","raw_affiliation_strings":["Reginald Jenney Professor of Anesthesia, Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School at Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reginald Jenney Professor of Anesthesia, Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School at Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8043,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92432559,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"117","issue":"1","first_page":"56","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stored-blood-transfusion","display_name":"stored blood transfusion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/autologous-blood-transfusion","display_name":"autologous blood transfusion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/reactive-hyperemia-index","display_name":"reactive hyperemia index","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7229999899864197},{"id":"https://openalex.org/keywords/plasma-nitrite","display_name":"plasma nitrite","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/storage-lesion","display_name":"storage lesion","score":0.46700000762939453},{"id":"https://openalex.org/keywords/plasma-hemoglobin","display_name":"plasma hemoglobin","score":0.5929999947547913},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/leukoreduced-blood","display_name":"leukoreduced blood","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8644751310348511},{"id":"https://openalex.org/C2780920261","wikidata":"https://www.wikidata.org/wiki/Q1363810","display_name":"Packed red blood cells","level":3,"score":0.6645454168319702},{"id":"https://openalex.org/C3019128504","wikidata":"https://www.wikidata.org/wiki/Q948806","display_name":"Reactive hyperemia","level":3,"score":0.6495429873466492},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5613021850585938},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5538003444671631},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.548528254032135},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.49642783403396606},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.47785159945487976},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.47154855728149414},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.44525817036628723},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.44210413098335266},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32262122631073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.290818989276886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27706974744796753},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.2342076599597931},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12714850902557373},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001793","descriptor_name":"Blood Preservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001804","descriptor_name":"Blood Transfusion, Autologous","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006940","descriptor_name":"Hyperemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/aln.0b013e31825575e6","doi":"https://doi.org/10.1097/aln.0b013e31825575e6","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31825575e6","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/117/1/56/658785/0000542-201207000-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:22531338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22531338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2962264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3980575","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3980575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3980575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anesthesiology","raw_type":"Text"},{"id":"pmh:oai:boa.unimib.it:10281/39099","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/39099","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.soton.ac.uk:337689","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/337689/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1097/aln.0b013e31825575e6","doi":"https://doi.org/10.1097/aln.0b013e31825575e6","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31825575e6","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/117/1/56/658785/0000542-201207000-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G4110177305","display_name":"Modulation of Hepcidin-Ferroportin Signaling using Small Molecules","funder_award_id":"R01DK082971","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1999665276.pdf","grobid_xml":"https://content.openalex.org/works/W1999665276.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1501002684","https://openalex.org/W1511302815","https://openalex.org/W1539918671","https://openalex.org/W1985999335","https://openalex.org/W2008567062","https://openalex.org/W2013291317","https://openalex.org/W2023421218","https://openalex.org/W2023556803","https://openalex.org/W2031178060","https://openalex.org/W2039979152","https://openalex.org/W2043897455","https://openalex.org/W2044682081","https://openalex.org/W2044758663","https://openalex.org/W2061272738","https://openalex.org/W2097654356","https://openalex.org/W2104530414","https://openalex.org/W2105080404","https://openalex.org/W2107921622","https://openalex.org/W2108555819","https://openalex.org/W2115807188","https://openalex.org/W2118621907","https://openalex.org/W2119378143","https://openalex.org/W2119434283","https://openalex.org/W2122036831","https://openalex.org/W2126770702","https://openalex.org/W2134987998","https://openalex.org/W2150027863","https://openalex.org/W2155467348","https://openalex.org/W2156376620","https://openalex.org/W2163889067","https://openalex.org/W4241694836"],"related_works":["https://openalex.org/W2560722154","https://openalex.org/W1627054669","https://openalex.org/W2105367624","https://openalex.org/W2595866329","https://openalex.org/W1983210318","https://openalex.org/W2529966809","https://openalex.org/W2950718932","https://openalex.org/W2572854815","https://openalex.org/W2559992365","https://openalex.org/W2524811009"],"abstract_inverted_index":{"BACKGROUND:":[0],"Transfusion":[1,229],"of":[2,46,77,81,130,149,175,206,215,230,251],"human":[3],"blood":[4,185],"stored":[5,49,83,135,154,208,217,234],"for":[6,50,235],"more":[7],"than":[8,151],"2":[9,112],"weeks":[10],"is":[11,238],"associated":[12,239],"with":[13,133,240],"increased":[14,203,241,249],"mortality":[15],"and":[16,79,99,107,114,142,165,180,194,248],"morbidity.":[17],"During":[18],"storage,":[19],"packed":[20,47,86,136,155,209,218,232],"erythrocytes":[21,48,137,156,219,233],"progressively":[22],"release":[23],"hemoglobin,":[24],"which":[25],"avidly":[26],"binds":[27],"nitric":[28,34],"oxide.":[29],"We":[30,56],"hypothesized":[31],"that":[32],"the":[33,70,124,191,197],"oxide":[35],"mediated":[36],"hyperemic":[37],"response":[38],"after":[39,44,117,128,147,152,204,213],"ischemia":[40],"would":[41],"be":[42],"reduced":[43],"transfusion":[45,129,148,205,214],"40":[51,236],"days.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"conducted":[57],"a":[58,94],"crossover":[59],"randomized":[60],"interventional":[61],"study,":[62],"enrolling":[63],"10":[64,108],"healthy":[65],"adults.":[66],"Nine":[67],"volunteers":[68],"completed":[69],"study.":[71],"Each":[72],"volunteer":[73],"received":[74],"one":[75,80],"unit":[76],"40-day":[78,131,150,207],"3-day":[82,134,153,216],"autologous":[84,231],"leukoreduced":[85],"erythrocytes,":[87,210],"on":[88],"different":[89],"study":[90],"days":[91,237],"according":[92],"to":[93],"randomization":[95],"scheme.":[96],"Blood":[97],"withdrawal":[98],"reactive":[100,120,245],"hyperemia":[101,121,246],"index":[102,122],"measurements":[103],"were":[104,145],"performed":[105],"before":[106],"min,":[109],"1":[110],"h,":[111,113],"4":[115,126],"h":[116,127],"transfusion.":[118],"The":[119],"during":[123],"first":[125],"compared":[132],"was":[138],"unchanged.":[139],"Plasma":[140,173,200],"hemoglobin":[141],"bilirubin":[143],"concentrations":[144,174,202,250],"higher":[146],"(P":[157,220],"=":[158,221],"0.02,":[159],"[95%":[160,167,223],"CI":[161,168,224],"difference":[162,169,225],"10-114":[163],"mg/l]":[164],"0.001,":[166],"0.6-1.5":[170],"mg/dl],":[171],"respectively).":[172],"potassium,":[176],"lactate":[177],"dehydrogenase,":[178],"haptoglobin,":[179],"cytokines,":[181],"as":[182,184],"well":[183],"pressure,":[186],"did":[187],"not":[188,212],"differ":[189],"between":[190],"two":[192],"transfusions":[193],"remained":[195],"within":[196],"normal":[198],"range.":[199],"nitrite":[201],"but":[211],"0.01,":[222],"0.446-0.66":[226],"\u03bcM]).":[227],"CONCLUSIONS:":[228],"hemolysis,":[242],"an":[243],"unchanged":[244],"index,":[247],"plasma":[252],"nitrite.":[253]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}