{"id":"https://openalex.org/W1999600810","doi":"https://doi.org/10.1038/nrc724","title":"Specialization of tumour vasculature","display_name":"Specialization of tumour vasculature","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W1999600810","doi":"https://doi.org/10.1038/nrc724","mag":"1999600810","pmid":"https://pubmed.ncbi.nlm.nih.gov/12635171"},"language":"en","primary_location":{"id":"doi:10.1038/nrc724","doi":"https://doi.org/10.1038/nrc724","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc724","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088477154","display_name":"Erkki I. Ruoslahti","orcid":"https://orcid.org/0000-0003-2496-3445","observed_orcids":["https://orcid.org/0000-0003-2496-3445"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erkki Ruoslahti","raw_affiliation_strings":["Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. ruoslahti@burnham.org","Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. ruoslahti@burnham.org","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088477154"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":2.4045,"has_fulltext":false,"cited_by_count":724,"citation_normalized_percentile":{"value":0.90914846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"2","first_page":"83","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.6769999861717224},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anti-angiogenic-cancer-therapy","display_name":"anti-angiogenic cancer therapy","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7441743612289429},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.661271870136261},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.6187595129013062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5549601912498474},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5320965051651001},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5043197870254517},{"id":"https://openalex.org/C2780965494","wikidata":"https://www.wikidata.org/wiki/Q11238641","display_name":"Lymphatic vessel","level":4,"score":0.45213454961776733},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4516817331314087},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.4463005065917969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4424675703048706},{"id":"https://openalex.org/C2909380610","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumour tissue","level":2,"score":0.42378753423690796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41032934188842773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33980196714401245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22114381194114685},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.16188707947731018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13943207263946533},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07033097743988037}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrc724","doi":"https://doi.org/10.1038/nrc724","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc724","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:12635171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12635171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306141","display_name":"Susan G. Komen for the Cure","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1485771066","https://openalex.org/W1494507441","https://openalex.org/W1508582865","https://openalex.org/W1519030262","https://openalex.org/W1559044733","https://openalex.org/W1559937222","https://openalex.org/W1570971207","https://openalex.org/W1573363574","https://openalex.org/W1575231005","https://openalex.org/W1577083632","https://openalex.org/W1582963778","https://openalex.org/W1587050401","https://openalex.org/W1588843917","https://openalex.org/W1762724222","https://openalex.org/W1905978178","https://openalex.org/W1967628309","https://openalex.org/W1967720639","https://openalex.org/W1971214445","https://openalex.org/W1974527643","https://openalex.org/W1980036500","https://openalex.org/W1983967012","https://openalex.org/W1985804036","https://openalex.org/W1989414395","https://openalex.org/W1990027846","https://openalex.org/W1990036692","https://openalex.org/W1995727373","https://openalex.org/W1995857537","https://openalex.org/W2001879388","https://openalex.org/W2004781757","https://openalex.org/W2009507555","https://openalex.org/W2012255417","https://openalex.org/W2015371482","https://openalex.org/W2022415270","https://openalex.org/W2023735985","https://openalex.org/W2024197175","https://openalex.org/W2024599421","https://openalex.org/W2025036947","https://openalex.org/W2025574528","https://openalex.org/W2029773366","https://openalex.org/W2031630601","https://openalex.org/W2034269086","https://openalex.org/W2036292414","https://openalex.org/W2039317622","https://openalex.org/W2040283898","https://openalex.org/W2042333083","https://openalex.org/W2053059044","https://openalex.org/W2065799167","https://openalex.org/W2065884286","https://openalex.org/W2067907901","https://openalex.org/W2067958384","https://openalex.org/W2068365812","https://openalex.org/W2068561314","https://openalex.org/W2071587956","https://openalex.org/W2073704598","https://openalex.org/W2075829745","https://openalex.org/W2077090481","https://openalex.org/W2084892332","https://openalex.org/W2087227581","https://openalex.org/W2091323735","https://openalex.org/W2098573045","https://openalex.org/W2100363932","https://openalex.org/W2104888958","https://openalex.org/W2105469517","https://openalex.org/W2113267611","https://openalex.org/W2115515762","https://openalex.org/W2117013761","https://openalex.org/W2122071072","https://openalex.org/W2123777674","https://openalex.org/W2129477849","https://openalex.org/W2150156158","https://openalex.org/W2152525228","https://openalex.org/W2155056678","https://openalex.org/W2155591311","https://openalex.org/W2155820414","https://openalex.org/W2156690430","https://openalex.org/W2159241628","https://openalex.org/W2161370863","https://openalex.org/W2161708429","https://openalex.org/W2166888397","https://openalex.org/W2169149833","https://openalex.org/W4213141530","https://openalex.org/W4244061122"],"related_works":["https://openalex.org/W986545895","https://openalex.org/W1994442425","https://openalex.org/W7099782568","https://openalex.org/W1980558722","https://openalex.org/W7162127803","https://openalex.org/W2998878714","https://openalex.org/W2063556542","https://openalex.org/W2280070554","https://openalex.org/W2024587123","https://openalex.org/W2141461285"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":38},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":38}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}