{"id":"https://openalex.org/W1999596396","doi":"https://doi.org/10.1093/infdis/166.4.919","title":"Single-Dose Cefixime versus Single-Dose Ceftriaxone in the Treatment of Antimicrobial-Resistant Neisseria gonorrhoeae Infection","display_name":"Single-Dose Cefixime versus Single-Dose Ceftriaxone in the Treatment of Antimicrobial-Resistant Neisseria gonorrhoeae Infection","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W1999596396","doi":"https://doi.org/10.1093/infdis/166.4.919","mag":"1999596396","pmid":"https://pubmed.ncbi.nlm.nih.gov/1527431"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/166.4.919","doi":"https://doi.org/10.1093/infdis/166.4.919","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/166.4.919","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017938543","display_name":"Pierre Plourde","orcid":"https://orcid.org/0000-0003-3089-4335","observed_orcids":["https://orcid.org/0000-0003-3089-4335"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]}],"countries":["KE"],"is_corresponding":true,"raw_author_name":"Pierre J. Plourde","raw_affiliation_strings":["Department of Medical Microbiology, University of Nairobi, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, University of Nairobi, Kenya","institution_ids":["https://openalex.org/I12859529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009352676","display_name":"MARK W. TYNDALL","orcid":"https://orcid.org/0000-0003-4450-5679","observed_orcids":["https://orcid.org/0000-0003-4450-5679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Tyndall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054407434","display_name":"Elizabeth Agoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Agoki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027879611","display_name":"John Ombette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Ombette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053070035","display_name":"L Slaney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie A. Slaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110120814","display_name":"L J D'Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lourdes J. D'Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110220414","display_name":"Jackoniah O. Ndinya\u2010Achola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jackoniah O. Ndinya-Achola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004563927","display_name":"Francis Allan Plummer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis A. Plummer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017938543"],"corresponding_institution_ids":["https://openalex.org/I12859529"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.7299,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.81875733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"166","issue":"4","first_page":"919","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefixime","display_name":"cefixime","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":1.0},{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gonorrhea","display_name":"gonorrhea","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9559999704360962},{"id":"https://openalex.org/keywords/single-dose-treatment","display_name":"single-dose therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oral-cephalosporins","display_name":"oral cephalosporins","score":0.8069999814033508},{"id":"https://openalex.org/keywords/gonococcal-urethritis","display_name":"gonococcal urethritis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cervicitis","display_name":"cervicitis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sexually-transmitted-infections","display_name":"sexually transmitted infections","score":0.843999981880188},{"id":"https://openalex.org/keywords/bacteriological-cure","display_name":"bacteriological cure","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2778243283","wikidata":"https://www.wikidata.org/wiki/Q163901","display_name":"Cefixime","level":4,"score":0.6083564162254333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5299568772315979},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5021865367889404},{"id":"https://openalex.org/C2776520383","wikidata":"https://www.wikidata.org/wiki/Q421713","display_name":"Ceftriaxone","level":3,"score":0.35221680998802185},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.3266312777996063},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.27809903025627136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1479591429233551},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1454823911190033},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.14398586750030518},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10442996025085449}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002439","descriptor_name":"Cefotaxime","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002439","descriptor_name":"Cefotaxime","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002439","descriptor_name":"Cefotaxime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002575","descriptor_name":"Uterine Cervicitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002575","descriptor_name":"Uterine Cervicitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006069","descriptor_name":"Gonorrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014526","descriptor_name":"Urethritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014526","descriptor_name":"Urethritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D020682","descriptor_name":"Cefixime","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/166.4.919","doi":"https://doi.org/10.1093/infdis/166.4.919","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/166.4.919","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:1527431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1527431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W164381428","https://openalex.org/W1966262566","https://openalex.org/W1968705794","https://openalex.org/W1982207616","https://openalex.org/W2003884152","https://openalex.org/W2005952948","https://openalex.org/W2043666887","https://openalex.org/W2055407957","https://openalex.org/W2055617372","https://openalex.org/W2112317973","https://openalex.org/W2338683983"],"related_works":["https://openalex.org/W2338683983","https://openalex.org/W1967590224","https://openalex.org/W2724766663","https://openalex.org/W1971091573","https://openalex.org/W1573717163","https://openalex.org/W2003884152","https://openalex.org/W2065370863","https://openalex.org/W2012135779","https://openalex.org/W2081764673","https://openalex.org/W4318913861"],"abstract_inverted_index":{"Sexually":[0],"transmitted":[1],"diseases":[2],"(STDs)":[3],"have":[4],"a":[5,54,66,117],"significant":[6],"adverse":[7],"effect":[8],"on":[9],"reproductive":[10],"and":[11,83,105,134],"child":[12],"health":[13],"worldwide.":[14],"The":[15,51],"control":[16],"of":[17,39,49,53,59,65,71,76,98,108,128],"STDs":[18],"such":[19],"as":[20,116],"gonorrhea":[21],"is":[22,121],"therefore":[23],"an":[24,28,43,122],"absolute":[25],"priority.":[26],"Cefixime,":[27,115],"oral":[29,56,119],"third-generation":[30],"cephalosporin":[31],"with":[32,63,103,113],"in":[33,80,85,88,96,132,136],"vitro":[34],"activity":[35],"similar":[36],"to":[37],"that":[38,64],"ceftriaxone,":[40],"may":[41],"be":[42],"effective":[44,123],"candidate":[45],"for":[46,73,125],"the":[47,74,126],"treatment":[48,75,127],"gonorrhea.":[50],"efficacy":[52],"single":[55,67,118],"400-mg":[57],"dose":[58,70],"cefixime":[60],"was":[61,94],"compared":[62],"intramuscular":[68],"250-mg":[69],"ceftriaxone":[72,104],"Neisseria":[77],"gonorrhoeae":[78],"urethritis":[79,131],"190":[81],"men":[82,133],"cervicitis":[84,135],"46":[86],"women":[87],"Nairobi,":[89],"Kenya.":[90],"A":[91],"bacteriologic":[92],"cure":[93],"recorded":[95],"100%":[97],"63":[99],"evaluatable":[100,110],"patients":[101,111],"treated":[102,112],"118":[106],"(98%)":[107],"121":[109],"cefixime.":[114],"dose,":[120],"alternative":[124],"uncomplicated":[129],"gonococcal":[130],"women.":[137]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}