{"id":"https://openalex.org/W1999549596","doi":"https://doi.org/10.1016/s1383-5742(00)00017-x","title":"Repair of O6-alkylguanine by alkyltransferases","display_name":"Repair of O6-alkylguanine by alkyltransferases","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W1999549596","doi":"https://doi.org/10.1016/s1383-5742(00)00017-x","mag":"1999549596","pmid":"https://pubmed.ncbi.nlm.nih.gov/10767620"},"language":"en","primary_location":{"id":"doi:10.1016/s1383-5742(00)00017-x","doi":"https://doi.org/10.1016/s1383-5742(00)00017-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1383-5742(00)00017-x","pdf_url":null,"source":{"id":"https://openalex.org/S155491289","display_name":"Mutation Research/Reviews in Mutation Research","issn_l":"1383-5742","issn":["1383-5742","1388-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Mutation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110184049","display_name":"Anthony E. Pegg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony E Pegg","raw_affiliation_strings":["Departments of Cellular and Molecular Physiology and Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, P.O. Box 850, 500 University Drive, Hershey, PA, USA. aep1@psu.edu","Departments of Cellular and Molecular Physiology and Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, P.O. Box 850, 500 University Drive, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Molecular Physiology and Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, P.O. Box 850, 500 University Drive, Hershey, PA, USA. aep1@psu.edu","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]},{"raw_affiliation_string":"Departments of Cellular and Molecular Physiology and Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, P.O. Box 850, 500 University Drive, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110184049"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":7.6604,"has_fulltext":false,"cited_by_count":576,"citation_normalized_percentile":{"value":0.98224824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"462","issue":"2-3","first_page":"83","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o6-alkylguanine","display_name":"O6-alkylguanine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alkyltransferase","display_name":"alkyltransferase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8820000290870667},{"id":"https://openalex.org/keywords/o6-methylguanine","display_name":"O6-methylguanine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/o6-benzylguanine","display_name":"O6-benzylguanine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.6200000047683716},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-degradation","display_name":"ubiquitin-proteasome degradation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7670000195503235},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8840000033378601},{"id":"https://openalex.org/keywords/temozolomide-resistance","display_name":"temozolomide resistance","score":0.8370000123977661},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7229999899864197},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2779527866","wikidata":"https://www.wikidata.org/wiki/Q21118735","display_name":"O-6-methylguanine-DNA methyltransferase","level":5,"score":0.6346733570098877},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5976613163948059},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46719905734062195},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4655839502811432},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46369636058807373},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.46016499400138855},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.44439736008644104},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43924155831336975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43280795216560364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4191468358039856},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.41158610582351685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2340717315673828},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1383-5742(00)00017-x","doi":"https://doi.org/10.1016/s1383-5742(00)00017-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1383-5742(00)00017-x","pdf_url":null,"source":{"id":"https://openalex.org/S155491289","display_name":"Mutation Research/Reviews in Mutation Research","issn_l":"1383-5742","issn":["1383-5742","1388-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Mutation Research","raw_type":"journal-article"},{"id":"pmid:10767620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10767620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1565972033","display_name":null,"funder_award_id":"CA57725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2421508871","display_name":null,"funder_award_id":"CA-18137","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G769859659","display_name":null,"funder_award_id":"CA 71976","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W77838834","https://openalex.org/W111616551","https://openalex.org/W130744417","https://openalex.org/W958327846","https://openalex.org/W1480525468","https://openalex.org/W1480645643","https://openalex.org/W1494707213","https://openalex.org/W1520044775","https://openalex.org/W1537479709","https://openalex.org/W1537769568","https://openalex.org/W1542441387","https://openalex.org/W1552690727","https://openalex.org/W1554249100","https://openalex.org/W1558094668","https://openalex.org/W1560251111","https://openalex.org/W1582226512","https://openalex.org/W1596629989","https://openalex.org/W1598305631","https://openalex.org/W1600352032","https://openalex.org/W1621140268","https://openalex.org/W1669617282","https://openalex.org/W1783782681","https://openalex.org/W1806652950","https://openalex.org/W1828007370","https://openalex.org/W1859592247","https://openalex.org/W1867674491","https://openalex.org/W1869160040","https://openalex.org/W1872551000","https://openalex.org/W1877934626","https://openalex.org/W1886120862","https://openalex.org/W1896894019","https://openalex.org/W1907545229","https://openalex.org/W1918200890","https://openalex.org/W1964030620","https://openalex.org/W1965405552","https://openalex.org/W1966287920","https://openalex.org/W1966682923","https://openalex.org/W1967090290","https://openalex.org/W1967625750","https://openalex.org/W1967842518","https://openalex.org/W1969543917","https://openalex.org/W1972872777","https://openalex.org/W1975111142","https://openalex.org/W1976052037","https://openalex.org/W1978103276","https://openalex.org/W1981174149","https://openalex.org/W1982249274","https://openalex.org/W1984086177","https://openalex.org/W1990226147","https://openalex.org/W1990557525","https://openalex.org/W1990739350","https://openalex.org/W1994577989","https://openalex.org/W1996344481","https://openalex.org/W1997631624","https://openalex.org/W1998747830","https://openalex.org/W1999265911","https://openalex.org/W2006672667","https://openalex.org/W2011643623","https://openalex.org/W2014362420","https://openalex.org/W2015456293","https://openalex.org/W2017182288","https://openalex.org/W2017701593","https://openalex.org/W2020832473","https://openalex.org/W2023666414","https://openalex.org/W2025605138","https://openalex.org/W2027141079","https://openalex.org/W2028491507","https://openalex.org/W2030439726","https://openalex.org/W2030481378","https://openalex.org/W2032152522","https://openalex.org/W2033493684","https://openalex.org/W2034469443","https://openalex.org/W2035698634","https://openalex.org/W2035796927","https://openalex.org/W2037916186","https://openalex.org/W2038964655","https://openalex.org/W2041829432","https://openalex.org/W2042857206","https://openalex.org/W2043470252","https://openalex.org/W2047244583","https://openalex.org/W2049124910","https://openalex.org/W2055315999","https://openalex.org/W2055338425","https://openalex.org/W2057812711","https://openalex.org/W2058609956","https://openalex.org/W2060898340","https://openalex.org/W2062132892","https://openalex.org/W2066411756","https://openalex.org/W2067283352","https://openalex.org/W2068057444","https://openalex.org/W2068448364","https://openalex.org/W2068767544","https://openalex.org/W2071616360","https://openalex.org/W2072946438","https://openalex.org/W2076557946","https://openalex.org/W2078080141","https://openalex.org/W2082214193","https://openalex.org/W2083722410","https://openalex.org/W2085917133","https://openalex.org/W2088279297","https://openalex.org/W2088486282","https://openalex.org/W2090338886","https://openalex.org/W2091628457","https://openalex.org/W2094133050","https://openalex.org/W2098140018","https://openalex.org/W2099191396","https://openalex.org/W2104955404","https://openalex.org/W2106816824","https://openalex.org/W2110371090","https://openalex.org/W2111960505","https://openalex.org/W2113144089","https://openalex.org/W2113742699","https://openalex.org/W2114956042","https://openalex.org/W2115227264","https://openalex.org/W2115639827","https://openalex.org/W2118090892","https://openalex.org/W2118247564","https://openalex.org/W2121021837","https://openalex.org/W2123002290","https://openalex.org/W2123070547","https://openalex.org/W2134175752","https://openalex.org/W2137488862","https://openalex.org/W2138198662","https://openalex.org/W2144148250","https://openalex.org/W2144394152","https://openalex.org/W2148615521","https://openalex.org/W2154637928","https://openalex.org/W2157438125","https://openalex.org/W2165509283","https://openalex.org/W2166862746","https://openalex.org/W2169694212","https://openalex.org/W2174123365","https://openalex.org/W2176312424","https://openalex.org/W2300179793","https://openalex.org/W2318421425","https://openalex.org/W2324032393","https://openalex.org/W2341685967","https://openalex.org/W2394645567","https://openalex.org/W2398138834","https://openalex.org/W2412744034","https://openalex.org/W2413089932","https://openalex.org/W2414766866","https://openalex.org/W2415004208","https://openalex.org/W2417295997","https://openalex.org/W4241480733","https://openalex.org/W4300798671","https://openalex.org/W6603183547","https://openalex.org/W6605158840","https://openalex.org/W6631168691","https://openalex.org/W6632183686","https://openalex.org/W6632222113","https://openalex.org/W6633231916","https://openalex.org/W6633393638","https://openalex.org/W6633581533","https://openalex.org/W6634976622","https://openalex.org/W6635614565","https://openalex.org/W6635667690","https://openalex.org/W6635892410","https://openalex.org/W6636740606","https://openalex.org/W6638256980","https://openalex.org/W6638560006","https://openalex.org/W6638853773","https://openalex.org/W6639585243","https://openalex.org/W6647998248","https://openalex.org/W6675799497","https://openalex.org/W6676813681","https://openalex.org/W6677656302","https://openalex.org/W6677772021","https://openalex.org/W6697726399","https://openalex.org/W6711863255","https://openalex.org/W6712251508"],"related_works":["https://openalex.org/W1968394537","https://openalex.org/W2063994948","https://openalex.org/W2071762351","https://openalex.org/W2157438125","https://openalex.org/W3154887287","https://openalex.org/W2030612391","https://openalex.org/W2351942949","https://openalex.org/W2465893683","https://openalex.org/W2327540589","https://openalex.org/W1987028324"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}