{"id":"https://openalex.org/W1999546892","doi":"https://doi.org/10.1016/0014-5793(88)80383-1","title":"A monoclonal anti\u2010thromboxane B2 antibody","display_name":"A monoclonal anti\u2010thromboxane B2 antibody","publication_year":1988,"publication_date":"1988-05-09","ids":{"openalex":"https://openalex.org/W1999546892","doi":"https://doi.org/10.1016/0014-5793(88)80383-1","mag":"1999546892","pmid":"https://pubmed.ncbi.nlm.nih.gov/3130275"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(88)80383-1","doi":"https://doi.org/10.1016/0014-5793(88)80383-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(88)80383-1","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113484962","display_name":"Margot Reinke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Margot Reinke","raw_affiliation_strings":["Department of Pharmacology, University of Erlangen-N\u00fcrnberg, FRG","Department of Pharmacology, University of Erlangen-N\u00fcrnberg, Universit\u00e4tsstrasse 22, D-8520 Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Erlangen-N\u00fcrnberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Pharmacology, University of Erlangen-N\u00fcrnberg, Universit\u00e4tsstrasse 22, D-8520 Erlangen, FRG","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027292872","display_name":"Kay Brune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kay Brune","raw_affiliation_strings":["Department of Pharmacology, University of Erlangen-Nu\u0308rnberg, Universita\u0308tsstrasse 22, D-8520 Erlangen, FRG","Department of Pharmacology, University of Erlangen-N\u00fcrnberg, Universit\u00e4tsstrasse 22, D-8520 Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Erlangen-Nu\u0308rnberg, Universita\u0308tsstrasse 22, D-8520 Erlangen, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Pharmacology, University of Erlangen-N\u00fcrnberg, Universit\u00e4tsstrasse 22, D-8520 Erlangen, FRG","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113484962"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.6525,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58083366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"232","issue":"1","first_page":"46","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.3440000116825104,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.625},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8370000123977661},{"id":"https://openalex.org/keywords/prostacyclin-metabolites","display_name":"prostacyclin metabolites","score":0.8899999856948853},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7571249008178711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48870280385017395},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4435444176197052},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2534802556037903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2353714108467102}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(88)80383-1","doi":"https://doi.org/10.1016/0014-5793(88)80383-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(88)80383-1","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:3130275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3130275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1491984790","https://openalex.org/W1964821535","https://openalex.org/W1978028800","https://openalex.org/W2024830218","https://openalex.org/W2025955829","https://openalex.org/W2030087792","https://openalex.org/W2052091668","https://openalex.org/W2053306032","https://openalex.org/W2059357449","https://openalex.org/W2144446627","https://openalex.org/W2319834083"],"related_works":["https://openalex.org/W2075676311","https://openalex.org/W1986522994","https://openalex.org/W2410430082","https://openalex.org/W2053894925","https://openalex.org/W2144446627","https://openalex.org/W2946690856","https://openalex.org/W1996942609","https://openalex.org/W2416610705","https://openalex.org/W1767476647","https://openalex.org/W1979742382"],"abstract_inverted_index":{"A":[0],"monoclonal":[1,82],"antibody":[2,85],"against":[3],"thromboxane":[4,50,54,92],"B2":[5,48,84,93],"which":[6],"may":[7],"be":[8,37],"used":[9],"in":[10,95,102],"standard":[11],"fluid":[12],"phase":[13],"radioimmunoassays":[14],"with":[15,40,59],"a":[16,24],"detection":[17],"limit":[18],"of":[19,27,67,77],"around":[20],"40":[21],"pg":[22],"and":[23,53,71],"binding":[25],"affinity":[26],"1.98":[28],"X":[29],"10(9)":[30],"M-1":[31],"is":[32],"described.":[33],"Limited":[34],"crossreactivity":[35,58],"could":[36],"observed":[38],"only":[39],"structurally":[41],"closely":[42],"related":[43],"compounds":[44],"such":[45],"as":[46,73,75,99,101],"2,3-dinor-thromboxane":[47],"(8.9%),":[49],"B1":[51],"(15.7%)":[52],"B3":[55],"(39.7%).":[56],"Detectable":[57],"11-dehydro-thromboxane":[60],"B2,":[61,63,65],"omega-carboxy-thromboxane":[62],"omega-hydroxy-thromboxane":[64],"prostaglandins":[66],"the":[68,91],"D-,":[69],"E-":[70],"F-type":[72],"well":[74,87,100],"metabolites":[76],"prostacyclin":[78],"was":[79],"lacking.":[80],"The":[81],"anti-thromboxane":[83],"proved":[86],"suited":[88],"for":[89],"measuring":[90],"content":[94],"tissue":[96],"culture":[97],"supernatants":[98],"human":[103],"serum.":[104]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}