{"id":"https://openalex.org/W1999526071","doi":"https://doi.org/10.1152/japplphysiol.000247.2001","title":"Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury","display_name":"Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1999526071","doi":"https://doi.org/10.1152/japplphysiol.000247.2001","mag":"1999526071","pmid":"https://pubmed.ncbi.nlm.nih.gov/11744654"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.000247.2001","doi":"https://doi.org/10.1152/japplphysiol.000247.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.000247.2001","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042661935","display_name":"Robert J. Talmadge","orcid":"https://orcid.org/0000-0002-8792-3312","observed_orcids":["https://orcid.org/0000-0002-8792-3312"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Talmadge","raw_affiliation_strings":["Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061;","Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061;","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049524546","display_name":"Michael J. Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. J. Castro","raw_affiliation_strings":["Department of Exercise Science, University of Georgia, Athens, 30602; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, University of Georgia, Athens, 30602; and","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109609242","display_name":"D F Apple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800610419","display_name":"Shepherd Center","ror":"https://ror.org/035hd8d68","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800610419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. F. Apple","raw_affiliation_strings":["Shepherd Center, Atlanta, Georgia 30309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shepherd Center, Atlanta, Georgia 30309","institution_ids":["https://openalex.org/I2800610419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110058167","display_name":"Gary A. Dudley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. A. Dudley","raw_affiliation_strings":["Department of Exercise Science, University of Georgia, Athens, 30602; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, University of Georgia, Athens, 30602; and","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.844,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.84365062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"92","issue":"1","first_page":"147","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":1.0},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.890999972820282},{"id":"https://openalex.org/keywords/mhc-iix","display_name":"MHC IIx","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mhc-iia","display_name":"MHC IIa","score":0.9449999928474426},{"id":"https://openalex.org/keywords/serca-isoforms","display_name":"SERCA isoforms","score":0.847000002861023},{"id":"https://openalex.org/keywords/serca2","display_name":"SERCA2","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serca1","display_name":"SERCA1","score":0.847000002861023},{"id":"https://openalex.org/keywords/ca2-atpase","display_name":"Ca2+-ATPase","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.8692848682403564},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6793681383132935},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5820626020431519},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.549006462097168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5306357741355896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5031842589378357},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.48714134097099304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4620022475719452},{"id":"https://openalex.org/C2776643329","wikidata":"https://www.wikidata.org/wiki/Q975459","display_name":"Vastus lateralis muscle","level":3,"score":0.42989280819892883},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4167746305465698},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.3103483319282532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30016547441482544},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.263241171836853},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2301076054573059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17338579893112183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1567613184452057},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12974950671195984},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09215134382247925},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08143439888954163},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014891","descriptor_name":"Weight Lifting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015114","descriptor_name":"Androstenediol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015114","descriptor_name":"Androstenediol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015114","descriptor_name":"Androstenediol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.000247.2001","doi":"https://doi.org/10.1152/japplphysiol.000247.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.000247.2001","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:11744654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11744654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1567217814","https://openalex.org/W1576732506","https://openalex.org/W1820228121","https://openalex.org/W1933616248","https://openalex.org/W1944916001","https://openalex.org/W1954617482","https://openalex.org/W1963590825","https://openalex.org/W1963872193","https://openalex.org/W1966830850","https://openalex.org/W1969116319","https://openalex.org/W1973047758","https://openalex.org/W1975445862","https://openalex.org/W1990019783","https://openalex.org/W1997210223","https://openalex.org/W1997889276","https://openalex.org/W2000915111","https://openalex.org/W2011868176","https://openalex.org/W2018893486","https://openalex.org/W2021260520","https://openalex.org/W2026940734","https://openalex.org/W2027047803","https://openalex.org/W2029591368","https://openalex.org/W2039633744","https://openalex.org/W2042969301","https://openalex.org/W2067600149","https://openalex.org/W2069389319","https://openalex.org/W2071160031","https://openalex.org/W2073388173","https://openalex.org/W2078660921","https://openalex.org/W2079585867","https://openalex.org/W2084361565","https://openalex.org/W2089264358","https://openalex.org/W2089424394","https://openalex.org/W2094542138","https://openalex.org/W2098275443","https://openalex.org/W2108604696","https://openalex.org/W2109054032","https://openalex.org/W2110396329","https://openalex.org/W2119333938","https://openalex.org/W2129903610","https://openalex.org/W2139985432","https://openalex.org/W2145377186","https://openalex.org/W2148458869","https://openalex.org/W2148764093","https://openalex.org/W2150040922","https://openalex.org/W2153736182","https://openalex.org/W2162967769","https://openalex.org/W2171508974","https://openalex.org/W2173701066","https://openalex.org/W2221943935","https://openalex.org/W2264236036","https://openalex.org/W2265825690","https://openalex.org/W2270124749","https://openalex.org/W2312414583","https://openalex.org/W2343227274","https://openalex.org/W2401664176","https://openalex.org/W2582288966","https://openalex.org/W3024731152"],"related_works":["https://openalex.org/W2079585867","https://openalex.org/W2149075623","https://openalex.org/W2031681863","https://openalex.org/W1820228121","https://openalex.org/W3173660946","https://openalex.org/W2072338371","https://openalex.org/W2089264358","https://openalex.org/W2012139407","https://openalex.org/W2270124749","https://openalex.org/W2010316511"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,10,70,142,183,229],"spinal":[3],"cord":[4],"injury":[5],"(SCI)":[6],"on":[7],"the":[8,33,68,220,249],"profile":[9],"sarco(endo)":[11],"plasmic":[12],"reticulum":[13],"calcium-ATPase":[14],"(SERCA)":[15],"and":[16,41,78,88,128,145,157,166,171,190,201,232,245,253],"myosin":[17],"heavy":[18],"chain":[19],"(MHC)":[20],"isoforms":[21,152,192,228,255],"in":[22,114,117,139,212,219,238,251],"individual":[23],"vastus":[24],"lateralis":[25],"(VL)":[26],"muscle":[27],"fibers":[28,72,96,102,108,118,148,165,185,239],"were":[29,35,53,81,186],"determined.":[30],"Biopsies":[31,48],"from":[32,37,49],"VL":[34,71,184],"obtained":[36,54],"SCI":[38,112,137,194],"subjects":[39,52],"6":[40,126,155,169,199],"24":[42,133,160,174,206],"wk":[43,60,127,156,161,170,175,200],"postinjury":[44],"(n":[45,62],"=":[46,63],"6).":[47],"nondisabled":[50],"(ND)":[51],"at":[55,125,132,154,159,168,173,198,205],"two":[56],"time":[57,222],"points":[58],"18":[59],"apart":[61],"4).":[64],"In":[65,135],"ND":[66,213],"subjects,":[67],"proportions":[69,141,182],"containing":[73],"MHC":[74,76,79,94,100,106,120,143,146,163,177,191,233,246,254],"I,":[75],"IIa,":[77],"IIx":[80,107,121],"46":[82],"+/-":[83,86,90,123,130,196,203],"3,":[84,87],"53":[85],"1":[89],"1%,":[91],"respectively.":[92],"Most":[93,99],"I":[95,144,164],"contained":[97,103,109],"SERCA2.":[98],"IIa":[101,147,178],"SERCA1.":[104],"All":[105],"SERCA1":[110],"exclusively.":[111],"resulted":[113,138],"significant":[115],"increases":[116],"with":[119,149,209],"(14":[122],"4%":[124],"16":[129],"2%":[131],"wk).":[134],"addition,":[136],"high":[140,181],"both":[150,230],"SERCA":[151,189,231,244,252],"(29%":[153],"54%":[158],"for":[162,176,188,243],"16%":[167],"38%":[172],"fibers).":[179],"Thus":[180,248],"mismatched":[187,242],"after":[193],"(19":[195],"3%":[197],"36":[202],"9%":[204],"wk)":[207],"compared":[208],"only":[210],"~5%":[211],"subjects.":[214],"These":[215],"data":[216],"suggest":[217],"that,":[218],"early":[221],"period":[223],"following":[224],"SCI,":[225],"fast":[226],"fiber":[227],"are":[234,241],"elevated":[235],"disproportionately,":[236],"resulting":[237],"that":[240],"isoforms.":[247],"adaptations":[250],"appear":[256],"to":[257],"occur":[258],"independently.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}