{"id":"https://openalex.org/W1999441965","doi":"https://doi.org/10.1055/s-2003-39017","title":"Genetics of Environmental Asthma","display_name":"Genetics of Environmental Asthma","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1999441965","doi":"https://doi.org/10.1055/s-2003-39017","mag":"1999441965","pmid":"https://pubmed.ncbi.nlm.nih.gov/16088538"},"language":"en","primary_location":{"id":"doi:10.1055/s-2003-39017","doi":"https://doi.org/10.1055/s-2003-39017","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2003-39017","pdf_url":null,"source":{"id":"https://openalex.org/S193428046","display_name":"Seminars in Respiratory and Critical Care Medicine","issn_l":"1069-3424","issn":["1069-3424","1098-9048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006013423","display_name":"David Zaas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Zaas","raw_affiliation_strings":["Pulmonary and Critical Care Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376759","display_name":"David A. Schwartz","orcid":"https://orcid.org/0000-0001-6743-8443","observed_orcids":["https://orcid.org/0000-0001-6743-8443","https://orcid.org/0000-0001-5352-069X"]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Schwartz","raw_affiliation_strings":["Pulmonary and Critical Care Division, Department of Medicine; Department of Veterans Affairs Medical Center; and Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine; Department of Veterans Affairs Medical Center; and Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210126298","https://openalex.org/I4210139568"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1823,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.55700725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"24","issue":"2","first_page":"185","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma-genetics","display_name":"asthma genetics","score":0.7179999947547913},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7599999904632568},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.628000020980835},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/candidate-gene-studies","display_name":"candidate gene association","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9909999966621399},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.652999997138977},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9909999966621399},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":1.0},{"id":"https://openalex.org/keywords/allergen-exposure","display_name":"allergen exposure","score":0.7120000123977661},{"id":"https://openalex.org/keywords/asthma-phenotypes","display_name":"asthma phenotypes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/multifactorial-inheritance","display_name":"multifactorial inheritance","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8924700021743774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7037638425827026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5270490646362305},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5204532146453857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43762046098709106},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.4245983958244324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41694778203964233},{"id":"https://openalex.org/C203083617","wikidata":"https://www.wikidata.org/wiki/Q5433302","display_name":"Family aggregation","level":3,"score":0.4126792550086975},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27992862462997437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20210233330726624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13009867072105408}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2003-39017","doi":"https://doi.org/10.1055/s-2003-39017","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2003-39017","pdf_url":null,"source":{"id":"https://openalex.org/S193428046","display_name":"Seminars in Respiratory and Critical Care Medicine","issn_l":"1069-3424","issn":["1069-3424","1098-9048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:16088538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in respiratory and critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029691739","https://openalex.org/W1995206077","https://openalex.org/W1978227207","https://openalex.org/W2157692694","https://openalex.org/W4306377338","https://openalex.org/W4283692002","https://openalex.org/W2055384766","https://openalex.org/W2151977852","https://openalex.org/W2398112978","https://openalex.org/W7099626687"],"abstract_inverted_index":{"The":[0,140],"prevalence":[1],"of":[2,18,61,77,106,116,130,142,161],"asthma":[3,62,89,117,143,155,172],"continues":[4],"to":[5,14,33,58,66,120,149,157,170,175],"increase":[6],"throughout":[7],"Western":[8],"societies":[9],"and":[10,42,46,63,146],"now":[11],"is":[12,21,31,53,126,144],"estimated":[13],"affect":[15],"nearly":[16],"10%":[17],"Americans.":[19],"Asthma":[20,125],"a":[22,27,54,127,150],"syndrome":[23],"that":[24,51,83,100,132,165],"results":[25],"when":[26],"genetically":[28],"susceptible":[29],"individual":[30],"exposed":[32],"specific":[34,97,121,176],"allergens,":[35],"which":[36],"triggers":[37],"airway":[38,43],"inflammation,":[39],"bronchial":[40],"hyperresponsiveness,":[41],"remodeling.":[44],"Family":[45],"twin":[47],"studies":[48,93],"have":[49,64,84,94],"shown":[50],"there":[52],"major":[55],"genetic":[56,163],"component":[57],"the":[59,68,104,114,159],"development":[60,105,115],"attempted":[65],"determine":[67],"heritable":[69],"risk.":[70],"Linkage":[71],"analysis":[72],"has":[73],"identified":[74],"several":[75,109],"areas":[76],"interest":[78],"on":[79],"multiple":[80,136,162],"different":[81,88,137],"chromosomes":[82],"been":[85],"associated":[86,102,112],"with":[87,103,113],"phenotypes.":[90],"Candidate":[91],"gene":[92,98,152],"looked":[95],"at":[96],"polymorphisms":[99],"are":[101,111],"asthma.":[107],"Finally,":[108],"genes":[110],"in":[118,173],"response":[119,174],"environmental":[122],"allergen":[123],"exposures.":[124],"heterogeneous":[128],"collection":[129],"diseases":[131],"can":[133],"result":[134,160],"from":[135],"pathological":[138],"processes.":[139],"inheritance":[141],"complex":[145],"not":[147],"due":[148],"single":[151],"mutation.":[153],"Rather,":[154],"appears":[156],"be":[158],"mutations":[164],"influence":[166],"an":[167],"individual's":[168],"susceptibility":[169],"develop":[171],"allergens.":[177]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}