{"id":"https://openalex.org/W1999415985","doi":"https://doi.org/10.1002/jez.1402450104","title":"Effects of colchicine\u2010 and cytochalasin B\u2010treatment on the intracellular distribution of yolk droplets, lipid bodies, and golgi apparatus of the chick neuroepithelial cells","display_name":"Effects of colchicine\u2010 and cytochalasin B\u2010treatment on the intracellular distribution of yolk droplets, lipid bodies, and golgi apparatus of the chick neuroepithelial cells","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1999415985","doi":"https://doi.org/10.1002/jez.1402450104","mag":"1999415985","pmid":"https://pubmed.ncbi.nlm.nih.gov/3351442"},"language":"en","primary_location":{"id":"doi:10.1002/jez.1402450104","doi":"https://doi.org/10.1002/jez.1402450104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.1402450104","pdf_url":null,"source":{"id":"https://openalex.org/S4210222064","display_name":"Journal of Experimental Zoology","issn_l":"0022-104X","issn":["0022-104X","1097-010X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110855289","display_name":"J.G. Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. G. Fernandez","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular y Anatom\u00eda, Universidad de Le\u00f3n, Spain","Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular y Anatom\u00eda, Universidad de Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080584572","display_name":"C.A. Chamorro","orcid":"https://orcid.org/0000-0001-6331-6916","observed_orcids":["https://orcid.org/0000-0001-6331-6916"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. A. Chamorro","raw_affiliation_strings":["Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064529599","display_name":"Paulino de Paz","orcid":"https://orcid.org/0000-0003-2531-595X","observed_orcids":["https://orcid.org/0000-0003-2531-595X"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"P. de Paz","raw_affiliation_strings":["Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108936376","display_name":"J.M. Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. M. Villar","raw_affiliation_strings":["Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biologi\u0301a Celular y Anatomi\u0301a, Universidad de Leo\u0301n, 24071 Leo\u0301n, Spain","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Departamento de Biologia Celular y Anatomia, Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064529599"],"corresponding_institution_ids":["https://openalex.org/I8833935"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11940053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"245","issue":"1","first_page":"17","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":1.0},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7910000085830688},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9589999914169312},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9850000143051147},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neurulation","display_name":"neurulation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.8093996047973633},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.7984516620635986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7508131265640259},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.736466646194458},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6694954633712769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6192871332168579},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5151001811027527},{"id":"https://openalex.org/C102225024","wikidata":"https://www.wikidata.org/wiki/Q1388375","display_name":"Neurulation","level":5,"score":0.4989917278289795},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.4914005994796753},{"id":"https://openalex.org/C2781321622","wikidata":"https://www.wikidata.org/wiki/Q181409","display_name":"Yolk","level":2,"score":0.4904007911682129},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.48463258147239685},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.45118269324302673},{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.43704503774642944},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.33508819341659546},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.33237728476524353},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.2929762005805969},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2713027894496918},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21852943301200867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18637153506278992},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10151660442352295},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06118473410606384},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004530","descriptor_name":"Egg Yolk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jez.1402450104","doi":"https://doi.org/10.1002/jez.1402450104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.1402450104","pdf_url":null,"source":{"id":"https://openalex.org/S4210222064","display_name":"Journal of Experimental Zoology","issn_l":"0022-104X","issn":["0022-104X","1097-010X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology","raw_type":"journal-article"},{"id":"pmid:3351442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3351442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental zoology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W622602913","https://openalex.org/W1638123324","https://openalex.org/W1825559930","https://openalex.org/W1967550048","https://openalex.org/W1976221184","https://openalex.org/W1976925324","https://openalex.org/W1978864905","https://openalex.org/W1988011153","https://openalex.org/W1988342802","https://openalex.org/W2013826540","https://openalex.org/W2014685428","https://openalex.org/W2015917880","https://openalex.org/W2016548100","https://openalex.org/W2035587751","https://openalex.org/W2036065234","https://openalex.org/W2047230286","https://openalex.org/W2064643986","https://openalex.org/W2068503454","https://openalex.org/W2069508601","https://openalex.org/W2082025075","https://openalex.org/W2125241063","https://openalex.org/W2140034535","https://openalex.org/W2403387545","https://openalex.org/W2912905182","https://openalex.org/W4298144317","https://openalex.org/W4298276982","https://openalex.org/W4301672445"],"related_works":["https://openalex.org/W2414354998","https://openalex.org/W2012793976","https://openalex.org/W2062376478","https://openalex.org/W2416153779","https://openalex.org/W1977734507","https://openalex.org/W2243887288","https://openalex.org/W1854324700","https://openalex.org/W2089967567","https://openalex.org/W2400589444","https://openalex.org/W2468853713"],"abstract_inverted_index":{"Treatment":[0],"with":[1,47,106],"colchicine":[2,48,107,116],"(antimicrotubular":[3],"agent)":[4,9],"and":[5,33,58,88,91,108],"cytochalasin":[6,109],"B":[7],"(antimicrofilamentous":[8],"has":[10],"been":[11],"used":[12],"to":[13,99],"investigate":[14],"the":[15,20,23,37,42,63,66,73,80,83,103,113,126,130,137,152],"possible":[16,122],"role":[17,124],"played":[18],"by":[19],"cytoskeleton":[21],"in":[22,51,72,95,102,129,136,156],"maintenance":[24,74,131],"of":[25,28,36,55,65,69,75,115,132],"intracellular":[26],"distribution":[27,53,77],"yolk":[29,56],"droplets,":[30],"lipid":[31,59,89],"bodies,":[32,60],"Golgi":[34,92,118,133],"apparatus":[35,93,119,134],"chick":[38,138,157],"neuroepithelial":[39,70,139],"cells.":[40],"On":[41,79],"one":[43],"hand,":[44,82],"embryos":[45,97,104],"treated":[46,105],"showed":[49],"modifications":[50],"their":[52],"patterns":[54],"droplets":[57],"which":[61],"suggests":[62],"involvement":[64],"microtubular":[67,127],"integrity":[68],"cells":[71,140],"normal":[76],"patterns.":[78],"other":[81],"close":[84],"relationships":[85],"between":[86],"vitelline":[87],"inclusions":[90],"observed":[94],"untreated":[96],"seems":[98],"be":[100,142],"kept":[101],"B.":[110],"Moreover,":[111],"from":[112],"effects":[114],"on":[117],"position":[120],"a":[121],"functional":[123],"for":[125],"system":[128],"polarity":[135],"can":[141],"proposed.":[143],"The":[144],"results":[145],"provided":[146],"here":[147],"constitute":[148],"new":[149],"information":[150],"about":[151],"cellular":[153],"mechanisms":[154],"involved":[155],"neurulation.":[158]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}