{"id":"https://openalex.org/W1999408043","doi":"https://doi.org/10.3109/08982104.2014.941861","title":"Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain","display_name":"Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain","publication_year":2014,"publication_date":"2014-07-24","ids":{"openalex":"https://openalex.org/W1999408043","doi":"https://doi.org/10.3109/08982104.2014.941861","mag":"1999408043","pmid":"https://pubmed.ncbi.nlm.nih.gov/25058447"},"language":"en","primary_location":{"id":"doi:10.3109/08982104.2014.941861","doi":"https://doi.org/10.3109/08982104.2014.941861","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08982104.2014.941861","pdf_url":null,"source":{"id":"https://openalex.org/S158583779","display_name":"Journal of Liposome Research","issn_l":"0898-2104","issn":["0898-2104","1532-2394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liposome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015617681","display_name":"Ghada Ahmed Abdelbary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ghada Ahmed Abdelbary","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085880900","display_name":"Mona Hassan Aburahma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mona Hassan Aburahma","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085880900"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":null,"apc_paid":null,"fwci":2.3376,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.85096889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"25","issue":"2","first_page":"107","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lornoxicam","display_name":"lornoxicam","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proniosomes","display_name":"proniosomes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mucoadhesive-gel","display_name":"mucoadhesive gel","score":0.906000018119812},{"id":"https://openalex.org/keywords/dental-pain","display_name":"dental pain","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.5989999771118164},{"id":"https://openalex.org/keywords/mucosal-drug-delivery","display_name":"mucosal drug delivery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/carbopol-hydrogel","display_name":"Carbopol hydrogel","score":0.7940000295639038},{"id":"https://openalex.org/keywords/span-60","display_name":"Span 60","score":0.8159999847412109},{"id":"https://openalex.org/keywords/niosomes","display_name":"niosomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/surfactant-structure","display_name":"surfactant structure","score":0.6819999814033508},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.925000011920929},{"id":"https://openalex.org/keywords/vesicle-size-distribution","display_name":"vesicle size distribution","score":0.6620000004768372},{"id":"https://openalex.org/keywords/oral-analgesia","display_name":"oral analgesia","score":0.5249999761581421},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2779040406","wikidata":"https://www.wikidata.org/wiki/Q2734874","display_name":"Lornoxicam","level":3,"score":0.9798884391784668},{"id":"https://openalex.org/C2780020223","wikidata":"https://www.wikidata.org/wiki/Q25323681","display_name":"Mucoadhesion","level":4,"score":0.8331570625305176},{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.8079640865325928},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5156720876693726},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.47615858912467957},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4217851161956787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3973262310028076},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33341526985168457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33012187480926514},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.2842142581939697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25306251645088196},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.24593526124954224},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.2168959677219391},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.20726516842842102},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.18439403176307678},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08061286807060242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002180","descriptor_name":"Candidiasis, Oral","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08982104.2014.941861","doi":"https://doi.org/10.3109/08982104.2014.941861","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08982104.2014.941861","pdf_url":null,"source":{"id":"https://openalex.org/S158583779","display_name":"Journal of Liposome Research","issn_l":"0898-2104","issn":["0898-2104","1532-2394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liposome Research","raw_type":"journal-article"},{"id":"pmid:25058447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25058447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of liposome research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W47558914","https://openalex.org/W91059903","https://openalex.org/W1480859163","https://openalex.org/W1569282206","https://openalex.org/W1863088915","https://openalex.org/W1965037589","https://openalex.org/W1967172038","https://openalex.org/W1968601352","https://openalex.org/W1971929282","https://openalex.org/W1972723441","https://openalex.org/W1974120683","https://openalex.org/W1974358459","https://openalex.org/W1976236482","https://openalex.org/W1978403317","https://openalex.org/W1978467122","https://openalex.org/W1987016173","https://openalex.org/W1988144726","https://openalex.org/W1989845428","https://openalex.org/W1990098432","https://openalex.org/W1992288425","https://openalex.org/W2000811519","https://openalex.org/W2001683505","https://openalex.org/W2002667071","https://openalex.org/W2007063468","https://openalex.org/W2007543270","https://openalex.org/W2011774579","https://openalex.org/W2020965737","https://openalex.org/W2027658624","https://openalex.org/W2028080874","https://openalex.org/W2028138888","https://openalex.org/W2031095463","https://openalex.org/W2031707158","https://openalex.org/W2033026349","https://openalex.org/W2034659893","https://openalex.org/W2034729671","https://openalex.org/W2035640123","https://openalex.org/W2038577579","https://openalex.org/W2039551585","https://openalex.org/W2041880062","https://openalex.org/W2050270937","https://openalex.org/W2052129346","https://openalex.org/W2052407213","https://openalex.org/W2063218342","https://openalex.org/W2065946738","https://openalex.org/W2066136928","https://openalex.org/W2073734087","https://openalex.org/W2077863421","https://openalex.org/W2078210094","https://openalex.org/W2080960382","https://openalex.org/W2080987428","https://openalex.org/W2130546300","https://openalex.org/W2133566692","https://openalex.org/W2150037370","https://openalex.org/W2150978345","https://openalex.org/W2152815646","https://openalex.org/W2157430128","https://openalex.org/W2161530911","https://openalex.org/W2162154830","https://openalex.org/W2163641558","https://openalex.org/W2295546322","https://openalex.org/W2328998058","https://openalex.org/W2911841778","https://openalex.org/W2916770640","https://openalex.org/W3148160939","https://openalex.org/W4229760124","https://openalex.org/W4232780883","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2912111325","https://openalex.org/W7160284605","https://openalex.org/W2417346207","https://openalex.org/W3214221262","https://openalex.org/W2901013542","https://openalex.org/W3134996573","https://openalex.org/W3177164137","https://openalex.org/W2033362260","https://openalex.org/W3130619300","https://openalex.org/W2993184570"],"abstract_inverted_index":{"Oro-dental":[0],"diseases":[1],"are":[2],"generally":[3],"associated":[4],"with":[5,97],"pain":[6,24,72],"that":[7,89,126,164,221],"is":[8,20,35,63],"controlled":[9],"using":[10,43,169],"oral":[11,57,99,160,195,241],"tablets":[12],"containing":[13,205],"NSAIDs.":[14],"Lornoxicam,":[15],"a":[16,231],"relatively":[17],"new":[18],"NSAID,":[19],"effective":[21],"in":[22,55,71],"relieving":[23,73],"accompanying":[25],"different":[26],"oro-dental":[27,38],"problems.":[28],"The":[29,101,118,184,217],"aim":[30],"of":[31,53,61,103,155,187,237],"the":[32,51,56,86,98,104,148,153,159,181,194,209,222,240],"current":[33],"research":[34],"to":[36,46,50,65,68,84,146],"prepare":[37,85],"analgesic":[39],"and":[40,74,111,131,151,178,208],"anti-inflammatory":[41],"gel":[42,207],"provesicular":[44],"approach":[45],"deliver":[47],"lornoxicam":[48,62,204,238],"directly":[49],"site":[52],"action":[54],"cavity.":[58,242],"Local":[59],"administration":[60],"expected":[64],"be":[66,227],"superior":[67],"systemic":[69],"delivery":[70,236],"poses":[75],"less":[76],"GIT":[77],"adverse":[78],"effects.":[79],"Different":[80],"surfactants":[81],"were":[82,121,127,140],"utilized":[83],"proniosomal":[87,119,144,191,224],"gels":[88,145,225],"rapidly":[90],"transform":[91],"into":[92,123,239],"nano-sized":[93,177],"niosomes":[94],"after":[95],"hydration":[96],"saliva.":[100],"effect":[102],"surfactant":[105],"structure":[106],"on":[107],"vesicles":[108],"size":[109],"distribution":[110],"entrapment":[112],"efficiency":[113],"percentage":[114],"(EE%)":[115],"was":[116,172,176,197],"investigated.":[117],"formulations":[120],"incorporated":[122],"carbopol":[124,206],"hydrogels":[125],"characterized":[128],"regarding":[129],"rheological":[130],"mucoadhesion":[132],"properties.":[133],"Moreover,":[134],"ex-vivo":[135],"mucosal":[136],"membrane":[137],"permeation":[138,149],"studies":[139],"conducted":[141],"for":[142,234],"selected":[143],"quantify":[147],"parameters":[150],"assess":[152],"amount":[154],"drug":[156,211],"deposited":[157],"within":[158],"mucosa.":[161],"Results":[162],"revealed":[163],"mucoadhesive":[165,223],"proniosomes":[166],"formulation":[167],"prepared":[168],"Span":[170],"60":[171],"optimal":[173],"as":[174,230],"it":[175],"also":[179],"showed":[180],"highest":[182],"EE%.":[183],"transmucosal":[185,235],"flux":[186],"lornoxicam,":[188],"from":[189],"these":[190],"formulations,":[192],"across":[193],"mucosa":[196],"significantly":[198],"higher":[199],"(p":[200],"<":[201],"0.05)":[202],"than":[203,215],"percent":[210],"diffused":[212],"increased":[213],"more":[214],"twofolds.":[216],"results":[218],"collectively":[219],"suggest":[220],"can":[226],"assertively":[228],"considered":[229],"promising":[232],"carrier":[233]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
