{"id":"https://openalex.org/W1999337265","doi":"https://doi.org/10.1002/jmv.10547","title":"Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen","display_name":"Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen","publication_year":2003,"publication_date":"2003-12-18","ids":{"openalex":"https://openalex.org/W1999337265","doi":"https://doi.org/10.1002/jmv.10547","mag":"1999337265","pmid":"https://pubmed.ncbi.nlm.nih.gov/14695661"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.10547","doi":"https://doi.org/10.1002/jmv.10547","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.10547","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081066622","display_name":"Yoshiki Murakami","orcid":"https://orcid.org/0000-0002-5360-8330","observed_orcids":["https://orcid.org/0000-0002-5360-8330"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiki Murakami","raw_affiliation_strings":["Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan. cm87490@rio.odn.ne.jp","Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan","Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan. cm87490@rio.odn.ne.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan","institution_ids":[]},{"raw_affiliation_string":"Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113740286","display_name":"Masahito Minami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahito Minami","raw_affiliation_strings":["Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111614260","display_name":"Yukiko Daimon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukiko Daimon","raw_affiliation_strings":["Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017078328","display_name":"Takeshi Okanoue","orcid":"https://orcid.org/0000-0002-2390-3400","observed_orcids":["https://orcid.org/0000-0002-2390-3400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Okanoue","raw_affiliation_strings":["Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Fukui Hospital, Sakuragaoka, Tsuruga, Fukui, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081066622"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.6095,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.93071697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"72","issue":"2","first_page":"203","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hbv-integration","display_name":"HBV DNA integration","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hbsag-loss","display_name":"HBsAg loss","score":0.7839999794960022},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.5920000076293945},{"id":"https://openalex.org/keywords/acute-hepatitis","display_name":"acute hepatitis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6340000033378601},{"id":"https://openalex.org/keywords/alu-pcr","display_name":"Alu-PCR","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.7899610996246338},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7112281918525696},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6135318875312805},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.607495129108429},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5294990539550781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.507412850856781},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5016481876373291},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4568522572517395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4549696743488312},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4413108825683594},{"id":"https://openalex.org/C194575299","wikidata":"https://www.wikidata.org/wiki/Q2843746","display_name":"Hepatitis B virus DNA polymerase","level":4,"score":0.42748260498046875},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.41660356521606445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3026808500289917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmv.10547","doi":"https://doi.org/10.1002/jmv.10547","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.10547","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:14695661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14695661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W126995585","https://openalex.org/W174518679","https://openalex.org/W1484728345","https://openalex.org/W1505468269","https://openalex.org/W1523170992","https://openalex.org/W1537396029","https://openalex.org/W1548901827","https://openalex.org/W1584236810","https://openalex.org/W1969787598","https://openalex.org/W1985743468","https://openalex.org/W1991676409","https://openalex.org/W1993144162","https://openalex.org/W1995085389","https://openalex.org/W1997047331","https://openalex.org/W2003916038","https://openalex.org/W2021065971","https://openalex.org/W2022337477","https://openalex.org/W2022423494","https://openalex.org/W2027686909","https://openalex.org/W2028538315","https://openalex.org/W2031510386","https://openalex.org/W2031936365","https://openalex.org/W2034438463","https://openalex.org/W2040778023","https://openalex.org/W2041880635","https://openalex.org/W2045750882","https://openalex.org/W2046382304","https://openalex.org/W2051589473","https://openalex.org/W2053738348","https://openalex.org/W2054255930","https://openalex.org/W2059956230","https://openalex.org/W2060534398","https://openalex.org/W2070264331","https://openalex.org/W2077311317","https://openalex.org/W2080054391","https://openalex.org/W2081422634","https://openalex.org/W2088599718","https://openalex.org/W2098740893","https://openalex.org/W2106571265","https://openalex.org/W2111255922","https://openalex.org/W2111496774","https://openalex.org/W2116207717","https://openalex.org/W2124911741","https://openalex.org/W2130207380","https://openalex.org/W2132778265","https://openalex.org/W2148614326","https://openalex.org/W2156552801","https://openalex.org/W2156922255","https://openalex.org/W2162693993","https://openalex.org/W2170517917","https://openalex.org/W2170678947","https://openalex.org/W2315619302","https://openalex.org/W2321367477","https://openalex.org/W4243692208","https://openalex.org/W4302382477","https://openalex.org/W4319704847"],"related_works":["https://openalex.org/W2321367477","https://openalex.org/W3147422206","https://openalex.org/W2140658349","https://openalex.org/W4210665135","https://openalex.org/W2006848916","https://openalex.org/W2018349786","https://openalex.org/W1995085389","https://openalex.org/W1968540453","https://openalex.org/W7096185287","https://openalex.org/W2142190347"],"abstract_inverted_index":{"The":[0,245],"integration":[1,137,164,223,250],"of":[2,11,22,53,65,75,143,155,171,184,214,233,251,261],"hepatitis":[3,56,111,151,179,194,203,238],"B":[4,57],"virus":[5,58],"(HBV)":[6],"DNA":[7,36,206],"in":[8,41,70,78,112,140,168,210,230,265,269],"the":[9,20,23,51,55,62,66,72,211,215,231,248,259,262],"liver":[10,94,145,186,198],"chronic":[12,107,122,133,161,177,192,236,242],"HBV":[13,35,205,252],"carriers":[14],"has":[15,29,80],"been":[16,31,82],"documented":[17],"extensively.":[18],"However,":[19],"status":[21,64],"viral":[24,67,222,256,263],"genome":[25,253,264],"during":[26,254],"acute":[27,102,150,202,255],"infection":[28],"not":[30,81],"assessed":[32],"conclusively.":[33],"While":[34],"sequences":[37,226],"are":[38],"detected":[39],"often":[40],"serum,":[42],"liver,":[43],"and":[44,69,95,106,152,181,187,239,258],"peripheral":[45],"blood":[46],"mononuclear":[47],"cells":[48],"(PBMCs)":[49],"after":[50],"clearance":[52],"serum":[54,114],"surface":[59],"antigen":[60],"(HBsAg),":[61],"precise":[63],"genome,":[68],"particular":[71],"possible":[73],"persistence":[74,260],"integrated":[76,209,267],"genomes":[77],"PBMCs,":[79],"established.":[83],"A":[84],"highly":[85],"sensitive":[86],"PCR-derived":[87],"assay":[88],"(Alu-PCR)":[89],"was":[90,116,138,165,207,227],"employed":[91],"to":[92],"re-examine":[93],"PBMC":[96,173,188],"specimens":[97,146,157],"obtained":[98],"from":[99,147,158,175,190,200],"patients":[100,148,159,180],"with":[101,127,149,160],"(n":[103,108,118,129],"=":[104,109,119,130],"19)":[105],"22)":[110],"whom":[113],"HBsAg":[115],"present":[117],"12)":[120],"(HBV-related":[121],"active":[123,134,178,193,237,243],"hepatitis)":[124],"or":[125],"absent":[126],"anti-HCV":[128],"10)":[131],"(HCV-related":[132],"hepatitis).":[135],"Viral":[136,163],"demonstrated":[139],"3":[141],"out":[142,154,170,183],"19":[144],"12":[153,156],"hepatitis.":[162,244],"also":[166,228],"observed":[167],"4":[169],"7":[172],"samples":[174,189],"HBV-related":[176,235],"2":[182],"10":[185],"HCV-related":[191,241],"patients.":[195],"In":[196],"one":[197],"specimen":[199],"an":[201,266],"patient,":[204],"found":[208,229],"intronic":[212],"sequence":[213],"tumour":[216],"necrosis":[217],"factor":[218],"(TNF)-induced":[219],"protein":[220],"gene;":[221],"into":[224],"cellular":[225],"PBMCs":[232],"four":[234],"two":[240],"results":[246],"demonstrate":[247],"early":[249],"infections":[257],"form":[268],"PBMCs.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}