{"id":"https://openalex.org/W1999294635","doi":"https://doi.org/10.1002/path.1711460105","title":"Transplantation of a segment of ileum to the external abdominal wall: An animal model of intestinal mucosal hyperplasia","display_name":"Transplantation of a segment of ileum to the external abdominal wall: An animal model of intestinal mucosal hyperplasia","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W1999294635","doi":"https://doi.org/10.1002/path.1711460105","mag":"1999294635","pmid":"https://pubmed.ncbi.nlm.nih.gov/3159864"},"language":"en","primary_location":{"id":"doi:10.1002/path.1711460105","doi":"https://doi.org/10.1002/path.1711460105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711460105","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111702365","display_name":"Paul Vincent Senior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. V. Senior","raw_affiliation_strings":["Department of Pathology, University of Newcastle-upon-Tyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Newcastle-upon-Tyne, U.K","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046967337","display_name":"C. J. Pritchett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. J. Pritchett","raw_affiliation_strings":["Department of Surgery, University of Newcastle-upon-Tyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Newcastle-upon-Tyne, U.K","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483419","display_name":"J. P. Sunter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J. P. Sunter","raw_affiliation_strings":["Department of Pathology, University of Newcastle-upon-Tyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Newcastle-upon-Tyne, U.K","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016027484","display_name":"David R. Appleton","orcid":"https://orcid.org/0000-0001-8570-1428","observed_orcids":["https://orcid.org/0000-0001-8570-1428"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. R. Appleton","raw_affiliation_strings":["Department of Medical Statistics, University of Newcastle-upon-Tyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics, University of Newcastle-upon-Tyne, U.K","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086739699","display_name":"Alexander J. Watson","orcid":"https://orcid.org/0000-0003-2135-4556","observed_orcids":["https://orcid.org/0000-0003-2135-4556"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. J. Watson","raw_affiliation_strings":["Department of Pathology, University of Newcastle-upon-Tyne, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Newcastle-upon-Tyne, U.K","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108483419"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.0697,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77077498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":"1","first_page":"39","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.05900000035762787,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crypt-hyperplasia","display_name":"crypt hyperplasia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/villous-atrophy","display_name":"villous atrophy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mechanical-trauma","display_name":"mechanical trauma","score":0.5590000152587891},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7289999723434448},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.8312534093856812},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6390786170959473},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5696595311164856},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.550730288028717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46220991015434265},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4324694573879242},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39551490545272827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34958478808403015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2367534637451172}],"mesh":[{"descriptor_ui":"D000009","descriptor_name":"Abdominal Muscles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/path.1711460105","doi":"https://doi.org/10.1002/path.1711460105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711460105","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:3159864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3159864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W142882535","https://openalex.org/W214948707","https://openalex.org/W1602789782","https://openalex.org/W1659776978","https://openalex.org/W1676028068","https://openalex.org/W1688596058","https://openalex.org/W1887031810","https://openalex.org/W1898436678","https://openalex.org/W1970466323","https://openalex.org/W1976391329","https://openalex.org/W1992323476","https://openalex.org/W1993831722","https://openalex.org/W1994608601","https://openalex.org/W1995508148","https://openalex.org/W2012354889","https://openalex.org/W2015587357","https://openalex.org/W2047609964","https://openalex.org/W2054574004","https://openalex.org/W2076391750","https://openalex.org/W2079013412","https://openalex.org/W2085375302","https://openalex.org/W2122493167","https://openalex.org/W2161710060","https://openalex.org/W2166388953","https://openalex.org/W2312267849","https://openalex.org/W2408996459","https://openalex.org/W2417186397","https://openalex.org/W2417834657","https://openalex.org/W2417938927","https://openalex.org/W2471715377","https://openalex.org/W2617554651","https://openalex.org/W2946970427"],"related_works":["https://openalex.org/W2404511096","https://openalex.org/W2411156085","https://openalex.org/W1457901642","https://openalex.org/W1982852292","https://openalex.org/W2051137629","https://openalex.org/W2072252174","https://openalex.org/W2065800173","https://openalex.org/W2418651513","https://openalex.org/W1887031810","https://openalex.org/W2100207204"],"abstract_inverted_index":{"When":[0],"a":[1,29,59,98],"segment":[2],"of":[3,28,35,39,44,61,89,100,132,142,168],"small":[4],"intestine":[5],"is":[6,175],"transplanted":[7],"to":[8,32,92,126],"the":[9,19,45,70,77,90,122,130,133,137,140,146,162],"external":[10],"abdominal":[11],"wall":[12],"in":[13,18,103,121,129,161,172],"rats":[14],"adaptive":[15],"changes":[16,46],"occur":[17],"exposed":[20],"mucosa.":[21],"These":[22],"probably":[23],"represent":[24],"an":[25,127],"extreme":[26],"example":[27],"physiological":[30],"response":[31],"one":[33],"type":[34],"trophic":[36],"influence--the":[37],"effect":[38],"mechanical":[40],"trauma.":[41],"The":[42,80,165],"nature":[43],"has":[47],"been":[48],"studied":[49],"at":[50],"7":[51],"weeks":[52],"after":[53],"externalization":[54],"using":[55],"simple":[56],"morphometry":[57],"and":[58,69,73,87,106,139,155],"number":[60],"cytokinetic":[62],"techniques":[63],"(thymidine":[64],"labelling,":[65],"vincristine-induced":[66],"metaphase":[67],"arrest":[68],"fraction-of-labelled-mitoses":[71],"method),":[72],"comparisons":[74],"drawn":[75],"with":[76],"normal":[78,95],"ileum.":[79],"exteriorized":[81],"mucosa":[82],"showed":[83],"marked":[84],"villus":[85],"atrophy":[86],"hyperplasia":[88],"crypts":[91,124],"three":[93],"times":[94,152],"size":[96,131],"as":[97],"result":[99],"increases":[101],"both":[102],"crypt":[104,107,147],"length":[105],"circumference.":[108],"Neither":[109],"metaplastic":[110],"nor":[111],"dysplastic":[112],"epithelial":[113],"abnormalities":[114],"were":[115,153,159],"observed.":[116],"Crypt-cell":[117],"production":[118],"rate":[119],"doubled":[120],"hyperplastic":[123,163],"due":[125],"increase":[128],"proliferation":[134],"zone":[135],"within":[136,145],"crypt,":[138],"distribution":[141],"proliferating":[143],"cells":[144,158],"changed.":[148],"But":[149],"cell":[150],"cycle":[151],"prolonged":[154],"more":[156],"maturing":[157],"retained":[160],"crypts.":[164],"potential":[166],"usefulness":[167],"this":[169],"model,":[170],"particularly":[171],"carcinogenicity":[173],"studies":[174],"considered.":[176]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}